{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:17:24Z","timestamp":1760782644855,"version":"3.40.5"},"reference-count":10,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p>Myocarditis attributed to Epstein-Barr virus (EBV) as the sole cause is a rare manifestation. Myocarditis ascribed to EBV infection in combination with other factors has been reported in a few more cases. We report a child who experienced active EBV infection and later, at 19 months of age, received a diagnosis of Pompe disease (acid \u03b1-glucosidase deficiency) with predominant cardiac involvement. The cardiac symptoms resolved at the end of the EBV infection. When the patient was recently seen, at 8 years of age, she had an increased left ventricular wall thickness but normal cardiac function. DNA analysis identified this patient as compound heterozygote for a mutant Tyr292Cys and a null allele. In light of genotype-phenotype correlation, it is notable that a Spanish patient with a functionally similar genotype (Tyr292Cys\/Arg854Stop) also had childhood Pompe disease with peripheral muscular involvement.<\/jats:p>","DOI":"10.1542\/peds.109.4.e65","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:17:55Z","timestamp":1092442675000},"page":"e65-e65","source":"Crossref","is-referenced-by-count":13,"title":["A Rare Presentation of Childhood Pompe Disease: Cardiac Involvement Provoked by Epstein-Barr Virus Infection"],"prefix":"10.1542","volume":"109","author":[{"given":"Melle D.","family":"Talsma","sequence":"first","affiliation":[{"name":"Beatrix Children\u2019s Hospital, Groningen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian A.","family":"Kroos","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus University, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gepke","family":"Visser","sequence":"additional","affiliation":[{"name":"Wilhelmina Children\u2019s Hospital, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan L.L.","family":"Kimpen","sequence":"additional","affiliation":[{"name":"Wilhelmina Children\u2019s Hospital, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klary E.","family":"Niezen","sequence":"additional","affiliation":[{"name":"Beatrix Children\u2019s Hospital, Groningen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"2021121006222262500_R1","doi-asserted-by":"crossref","unstructured":"Hebert MM, Yu C, Towbin JA, Rogers BB. 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