{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:48:53Z","timestamp":1792838933580,"version":"4.5.0"},"reference-count":39,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:p>Objective. Urinary tract infections (UTIs) are a common clinical problem in febrile infants younger than 8 weeks old, with a prevalence between 5% and 11%. Previous studies have noted that jaundice may be one of the first signs of a bacterial infection in infants. Our goal was to determine the incidence of UTIs in asymptomatic, jaundiced infants younger than 8 weeks old and to determine which historical and laboratory parameters are associated with UTIs.<\/jats:p>\n                  <jats:p>Methods. We prospectively evaluated asymptomatic, jaundiced infants younger than 8 weeks old for evidence of a UTI (defined as &amp;gt;10 000 colony-forming units per milliliter of a single pathogen, obtained by bladder catheterization). A serum fractionated bilirubin level was obtained on all study patients. Detailed questionnaires were completed, which included demographic information, prenatal, intrapartum, and postnatal events.<\/jats:p>\n                  <jats:p>Results. Twelve (7.5%) of 160 infants had a UTI (95% confidence interval: 3.9%\u201312.7%). Isolated organisms included Escherichia coli, Enterobacter cloacae, Enterococcus, Klebsiella pneumoniae, group B Streptococcus, Streptococcus viridans, and Staphylococcus aureus. Patients with the onset of jaundice after 8 days of age had a higher incidence of UTI, 6 (50%) of 12 infants in the positive culture group, versus 15 (10%) of 148 infants in the negative culture group. Abnormal urinalysis and microscopy results were noted in 5 (42%) of 12 infants with a UTI, and 6 (55%) of 11 infants had abnormal renal ultrasound results.<\/jats:p>\n                  <jats:p>Conclusion. A UTI was found in 7.5% of asymptomatic, afebrile, jaundiced infants younger than 8 weeks old. In addition, infants with the onset of jaundice after 8 days of age or patients with an elevated conjugated bilirubin fraction were more likely to have a UTI. Therefore, we recommend that testing for a UTI be included as part of the evaluation in asymptomatic, jaundiced infants presenting to the emergency department.<\/jats:p>","DOI":"10.1542\/peds.109.5.846","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T20:17:55Z","timestamp":1092428275000},"page":"846-851","source":"Crossref","is-referenced-by-count":126,"title":["Jaundice as an Early Diagnostic Sign of Urinary Tract Infection in Infancy"],"prefix":"10.1542","volume":"109","author":[{"given":"Francisco J.","family":"Garcia","sequence":"first","affiliation":[{"name":"From the Division of Emergency and Transport Medicine, Childrens Hospital Los Angeles, Los Angeles, California; and the Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"Nager","sequence":"additional","affiliation":[{"name":"From the Division of Emergency and Transport Medicine, Childrens Hospital Los Angeles, Los Angeles, California; and the Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2002,5,1]]},"reference":[{"key":"2021121006290484600_R1","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, Provisional Committee for Quality Improvement and Subcommittee on Hyperbilirubinemia. 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