{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:05:31Z","timestamp":1761717931769,"version":"3.40.5"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:p>We report an infant presenting with constipation, whose history and physical examination initiated the investigation that led to the diagnosis of the Currarino triad in the proband and 2 other family members.<\/jats:p>","DOI":"10.1542\/peds.109.5.961","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:17:55Z","timestamp":1092442675000},"page":"961-965","source":"Crossref","is-referenced-by-count":6,"title":["Is It More Than Just Constipation?"],"prefix":"10.1542","volume":"109","author":[{"given":"Rani S.","family":"Gereige","sequence":"first","affiliation":[{"name":"University of South Florida&#x2028; Department of Pediatrics&#x2028; All Children\u2019s Hospital&#x2028; St Petersburg, FL 33701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime L.","family":"Frias","sequence":"additional","affiliation":[{"name":"Birth Defects Center&#x2028; University of South Florida&#x2028; Department of Pediatrics&#x2028; Tampa, FL 33606"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2002,5,1]]},"reference":[{"key":"2021121006295532100_R1","doi-asserted-by":"crossref","unstructured":"Baker SS, Liptak GS, Colletti RB, et al. Constipation in infants and children: evaluation and treatment. A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr.1999;29:612\u2013626","DOI":"10.1097\/00005176-199911000-00029"},{"key":"2021121006295532100_R2","doi-asserted-by":"crossref","unstructured":"Currarino G, Coln D, Votteler T. Triad of anorectal, sacral, and presacral anomalies. AJR Am J Roentgenol.1981;137:395\u2013398","DOI":"10.2214\/ajr.137.2.395"},{"key":"2021121006295532100_R3","doi-asserted-by":"crossref","unstructured":"Kirks DR, Merten DF, Filston HC, Oakes WJ. The Currarino triad: complex of anorectal malformation, sacral bony abnormality, and presacral mass. Pediatr Radiol.1984;14:220\u2013225","DOI":"10.1007\/BF01042245"},{"key":"2021121006295532100_R4","doi-asserted-by":"crossref","unstructured":"Pfluger T, Czekalla R, Koletzko S, et al. MRI and radiographic findings in Currarino\u2019s triad. Pediatr Radiol.1996;26:524\u2013527","DOI":"10.1007\/BF01372233"},{"key":"2021121006295532100_R5","doi-asserted-by":"crossref","unstructured":"Nour S, Kumar D, Dickson J. Anorectal malformations with sacral bony abnormalities. Arch Dis Child.1989;64:1618\u20131620","DOI":"10.1136\/adc.64.11.1618"},{"key":"2021121006295532100_R6","doi-asserted-by":"crossref","unstructured":"Lynch SA, Wang Y, Strachan T, Burn J, Lindsay S. Autosomal dominant sacral agenesis: Currarino syndrome. J. Med. Genet.2000;37:561\u2013566","DOI":"10.1136\/jmg.37.8.561"},{"key":"2021121006295532100_R7","unstructured":"Sharma AK, Sharma CS, Gupta AK, Sarin YK, Agarwal LD, Zaffar M. Teratomas in pediatric age group: experience with 75 cases. Indian Pediatr.1993;30:689\u2013694"},{"key":"2021121006295532100_R8","doi-asserted-by":"crossref","unstructured":"Sonnino RE, Chou S, Guttman FM. Hereditary sacrococcygeal teratomas. J Pediatr Surg.1989;24:1074\u20131075","DOI":"10.1016\/S0022-3468(89)80219-2"},{"key":"2021121006295532100_R9","doi-asserted-by":"crossref","unstructured":"Brem H, Beaver BL, Colombani PM, et al. Neonatal diagnosis of a presacral mass in the presence of congenital anal stenosis and partial sacral agenesis. J Pediatr Surg.1989;24:1076\u20131078","DOI":"10.1016\/S0022-3468(89)80220-9"},{"key":"2021121006295532100_R10","doi-asserted-by":"crossref","unstructured":"Yates VD, Wilroy RS, Whitington L, Simmons JCH. Anterior sacral defects: an autosomal dominantly inherited condition. J Pediatr.1983;102:239\u2013242","DOI":"10.1016\/S0022-3476(83)80528-9"},{"key":"2021121006295532100_R11","doi-asserted-by":"crossref","unstructured":"Ashcraft KW, Holder TM. Hereditary presacral teratoma. J Pediatr Surg.1974;9:691\u2013697","DOI":"10.1016\/0022-3468(74)90107-9"},{"key":"2021121006295532100_R12","doi-asserted-by":"crossref","unstructured":"Ross AJ, Ruiz-Perez V, Wang Y, et al. A Homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nature Genet.1998;20:358\u2013361","DOI":"10.1038\/3828"},{"key":"2021121006295532100_R13","doi-asserted-by":"crossref","unstructured":"Chiang C, Litingtung Y, Lee E, et al. Cyclopia and defective axial patterning in mice lacking Sonic Hedgehog gene function. Nature.1996;383:407\u2013413","DOI":"10.1038\/383407a0"},{"key":"2021121006295532100_R14","doi-asserted-by":"crossref","unstructured":"Vargas FR, Roessler E, Gaudenz K, et al. Analysis of the human Sonic Hedgehog coding and promoter regions in sacral agenesis, triphalyngeal thumb, and mirror polydactyly. Hum Genet.1998;102:387\u2013392","DOI":"10.1007\/s004390050709"},{"key":"2021121006295532100_R15","doi-asserted-by":"crossref","unstructured":"Hagan DM, Ross AJ, Strachan T, et al. Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. Am J Hum Genet.2000;66:1504\u20131515","DOI":"10.1086\/302899"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/109\/5\/961\/1115462\/pe0502000961.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/109\/5\/961\/1115462\/pe0502000961.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T14:57:52Z","timestamp":1639148272000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/109\/5\/961\/64301\/Is-It-More-Than-Just-Constipation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,1]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2002,5,1]]},"published-print":{"date-parts":[[2002,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.109.5.961","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2002,5,1]]}}}