{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:41:54Z","timestamp":1775479314809,"version":"3.50.1"},"reference-count":10,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:p>A 4-year-old Turkish girl was referred to our hospital with the findings of encephalopathy and pancytopenia. She had a history of severe abdominal cramps and gastrointestinal bleeding. A confused state, muscle pain and weakness, erythema-bullous and erythema-nodosum\u2013like skin lesions, and alopecia were observed at her hospitalization. All of these symptoms resolved on follow-up. On laboratory investigation severe thrombocytopenia and leukopenia, mild anemia, a moderate increase in aspartate aminotransferase and alanine aminotransferase levels were detected. After reevaluating her medical history, it was learned that she had accidentally taken 1.3 to 1.5 mg\/kg of colchicine 3 to 4 days before her first hospitalization.<\/jats:p>\n               <jats:p>The possibility of misdiagnosis of colchicine intoxication should be borne in mind, and pediatricians must be aware of its toxic effects, especially in areas where patients with familial Mediterranean fever are present.<\/jats:p>","DOI":"10.1542\/peds.109.5.971","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:17:55Z","timestamp":1092442675000},"page":"971-973","source":"Crossref","is-referenced-by-count":35,"title":["Late Diagnosis of Severe Colchicine Intoxication"],"prefix":"10.1542","volume":"109","author":[{"given":"Ayfer Gu\u0308r","family":"Gu\u0308ven","sequence":"first","affiliation":[{"name":"Department of Pediatrics&#x2028; Akdeniz University Medical Faculty&#x2028; 07070 Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Bahat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics&#x2028; Akdeniz University Medical Faculty&#x2028; 07070 Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema","family":"Akman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics&#x2028; Akdeniz University Medical Faculty&#x2028; 07070 Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reha","family":"Artan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics&#x2028; Akdeniz University Medical Faculty&#x2028; 07070 Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Erol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics&#x2028; Akdeniz University Medical Faculty&#x2028; 07070 Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2002,5,1]]},"reference":[{"key":"2021121006290997400_R1","doi-asserted-by":"crossref","unstructured":"Ben-Chetrit E, Levy M. Colchicine: 1998 update. Semin Arthritis Rheum.1998;28:48\u201359","DOI":"10.1016\/S0049-0172(98)80028-0"},{"key":"2021121006290997400_R2","doi-asserted-by":"crossref","unstructured":"Goldfinger SE. Colchicine for familial Mediterranean fever. J Med.1972;287:1302","DOI":"10.1056\/NEJM197212212872514"},{"key":"2021121006290997400_R3","unstructured":"o\u0308zkan E, Okur o\u0308, Ekmekc\u0327i A, o\u0308zcan R, Tag T. A new approach to the treatment of periodic fever. Med Bull Istanbul.1972;5:44\u201349"},{"key":"2021121006290997400_R4","unstructured":"Valenzuela P, Paris E, Oberpauer B, Rios JC, Concha F. Overdose of colchicine in a three-year-old child. Vet Hum Toxicol.1995;37:366\u2013367"},{"key":"2021121006290997400_R5","doi-asserted-by":"crossref","unstructured":"Goldbart A, Press J, Sofer S, Kapelushnik J. Near fatal colchicine intoxication in a child. A case report. Eur J Pediatr.2000;159:895\u2013897","DOI":"10.1007\/PL00008364"},{"key":"2021121006290997400_R6","unstructured":"Dubois V, Rey N, Constant H, Scherrmann JM, Berthier JC, Aulagner G. Colchicine poisoning apropos of a pediatric case [in French]. Therapie.1994;49:339\u2013342"},{"key":"2021121006290997400_R7","doi-asserted-by":"crossref","unstructured":"Stahl N, Weinberger A, Benjamin D, Pinkhas J. Fatal colchicine poisoning in a boy with familial Mediterranean fever. Am J Med Sci.1979;278:77\u201381","DOI":"10.1097\/00000441-197907000-00009"},{"key":"2021121006290997400_R8","doi-asserted-by":"crossref","unstructured":"Harel L, Mukamel M, Amir J, Staussberg R, Cohen AH, Varsano I. Colchicine-induced myoneuropathy in childhood. Eur J Pediatr.1998;157:853\u2013855","DOI":"10.1007\/s004310050952"},{"key":"2021121006290997400_R9","doi-asserted-by":"crossref","unstructured":"Gooneraute BWM. Massive generalized alopecia after poisoning by colchicines. BMJ.1966;1:1023\u201324","DOI":"10.1136\/bmj.1.5494.1023"},{"key":"2021121006290997400_R10","doi-asserted-by":"crossref","unstructured":"Baud FJ, Sabouraud A, Vicaut E, Taboulet P, Lang J, Bismuth C. Treatment of severe colchicine overdose with colchicine-specific Fab fragments. N Eng J Med.1995;332:642\u2013645","DOI":"10.1056\/NEJM199503093321004"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/109\/5\/971\/1115025\/pe0502000971.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/109\/5\/971\/1115025\/pe0502000971.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T14:56:27Z","timestamp":1639148187000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/109\/5\/971\/64284\/Late-Diagnosis-of-Severe-Colchicine-Intoxication"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,1]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2002,5,1]]},"published-print":{"date-parts":[[2002,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.109.5.971","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,1]]}}}