{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:00:24Z","timestamp":1789837224010,"version":"4.0.1"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:p>Objective. Infants with meconium aspiration syndrome (MAS) have marked surfactant dysfunction. Airways and alveoli of affected neonates contain meconium, inflammatory cells, inflammatory mediators, edema fluid, protein, and other debris. The objective of this study was to compare treatment with bronchoalveolar lavage using dilute Surfaxin with standard therapy in a population of newborn infants with MAS.<\/jats:p><jats:p>Methods. Inclusion criteria were 1) gestational age \u226535 weeks, 2) enrollment within 72 hours of birth, 3) diagnosis of MAS, 4) need for mechanical ventilation, and 5) an oxygenation index \u22658 and \u226425. Subjects were randomized to either lavage with Surfaxin or standard care (2:1 proportion). In lavaged infants, a volume of 8 mL\/kg dilute Surfaxin (2.5 mg\/mL) was instilled into each lung over approximately 20 seconds followed by suctioning after 5 ventilator breaths. The procedure was repeated twice. The third and final lavage was with a more concentrated solution (10 mg\/mL) of Surfaxin.<\/jats:p><jats:p>Results. Twenty-two infants were enrolled (15 Surfaxin and 7 control). Demographic characteristics were similar. There were trends (not significant) for Surfaxin-lavaged infants to be weaned from mechanical ventilation earlier (mean of 6.3 vs 9.9 days, respectively), as well as to have a more rapid decline in their oxygenation indexes compared with control infants, the latter difference persisting for the 96-hour-long study period. The therapy was safe and generally well tolerated by the infants.<\/jats:p><jats:p>Conclusions. Dilute Surfaxin lavage seems to be a safe and potentially effective therapy in the treatment of MAS. Data from this investigation support future prospective, controlled clinical trials of bronchoalveolar lavage with Surfaxin in neonates with MAS.<\/jats:p>","DOI":"10.1542\/peds.109.6.1081","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:17:55Z","timestamp":1092442675000},"page":"1081-1087","source":"Crossref","is-referenced-by-count":146,"title":["A Multicenter, Randomized, Controlled Trial Comparing Surfaxin (Lucinactant) Lavage With Standard Care for Treatment of Meconium Aspiration Syndrome"],"prefix":"10.1542","volume":"109","author":[{"given":"Thomas E.","family":"Wiswell","sequence":"first","affiliation":[{"name":"Discovery Laboratories, Inc, Doylestown, Pennsylvania"},{"name":"Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail R.","family":"Knight","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology, Departments of Pediatrics at Children\u2019s Hospital and Health Center of San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil N.","family":"Finer","sequence":"additional","affiliation":[{"name":"University of California at San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Donn","sequence":"additional","affiliation":[{"name":"University of Michigan Health System, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Desai","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamurthy C.","family":"Sekar","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Oklahoma, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Sharp Mary Birch Hospital for Women, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Keszler","sequence":"additional","affiliation":[{"name":"Georgetown University Medial Center, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valya E.","family":"Visser","sequence":"additional","affiliation":[{"name":"Carolinas Medical Center, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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