{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:42:50Z","timestamp":1772628170492,"version":"3.50.1"},"reference-count":56,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:p>Objective. To study neutrophil activation in circulation as a sign of systemic inflammation in preterm infants with respiratory distress syndrome.<\/jats:p><jats:p>Methods. The study comprised very low birth weight preterm infants who had respiratory distress syndrome and required intubation and mechanical ventilation (n = 51), 1-day-old preterm infants who had no need for mechanical ventilation (n = 12), term infants (n = 47), and adult volunteers (n = 25). Neutrophil surface expression of CD11b was quantified with flow cytometry.<\/jats:p><jats:p>Results. In preterm infants with respiratory distress syndrome, neutrophil CD11b expression during the first day of life was higher than in cord blood (mean: 165 relative fluorescence units [RFU] [standard deviation [SD]: 53], n = 29 vs 83 RFU [SD: 21], n = 11; 95% confidence interval [CI] for difference: 59\u2013106) or in preterm infants without mechanical ventilation (106 RFU [SD: 33], n = 12; 95% CI for difference: 17\u201390). CD11b expression decreased by age of 10 days. CD11b expression was lower in preterm cord than in term cord blood (95% CI for difference: 5\u201353). However, in preterm infants with respiratory distress syndrome aged 2 to 5 days, it was higher than in term infants of that age.<\/jats:p><jats:p>Conclusions. The observations demonstrate an early transient postnatal neutrophil activation indicative of systemic inflammation that may contribute to the tissue injury in preterm infants with respiratory distress syndrome.<\/jats:p>","DOI":"10.1542\/peds.110.1.36","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:17:55Z","timestamp":1092442675000},"page":"36-41","source":"Crossref","is-referenced-by-count":54,"title":["Neutrophil Activation in Preterm Infants Who Have Respiratory Distress Syndrome"],"prefix":"10.1542","volume":"110","author":[{"given":"Irmeli","family":"Nupponen","sequence":"first","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland"},{"name":"Hospital for Children and Adolescents, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Pesonen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sture","family":"Andersson","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents, Helsinki, Finland"},{"name":"Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aila","family":"Ma\u0308kela\u0308","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland"},{"name":"Hospital for Children and Adolescents, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riikka","family":"Turunen","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland"},{"name":"Hospital for Children and Adolescents, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"Rheumatism Foundation Hospital, Heinola, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Repo","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland"},{"name":"Department of Medicine, Division of Infectious Diseases, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"2021121006180357700_R1","doi-asserted-by":"crossref","unstructured":"The ACCP\/SCCM Consensus Conference Committee. 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