{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:26:53Z","timestamp":1780471613606,"version":"3.54.1"},"reference-count":20,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p>Objective. Kawasaki disease (KD) was first reported by Tomisaku Kawasaki in 1967 in Japan. Large-scale nationwide epidemiologic surveys have been conducted continuously by the Japan Kawasaki Disease Research Committee; however, there were very few reports of KD before 1967. This study was performed to clarify when KD appeared in Japan.<\/jats:p><jats:p>Design. We investigated the medical charts of patients who had been hospitalized at Tokyo University Hospital between 1940 and 1965.<\/jats:p><jats:p>Results. We identified 10 patients whose clinical signs fulfilled the criteria for KD. The ages of the patients ranged from 8 months to 5 years, and their final diagnoses were Stevens-Johnson syndrome, allergic toxic erythema, Izumi fever, scarlet fever, and cervical lymphadenitis. These 10 patients presented between 1950 and 1964, and no confirmed cases were seen between 1940 and 1949.<\/jats:p><jats:p>Conclusions. Our findings suggested that KD patients were rare before 1950 in Japan.<\/jats:p>","DOI":"10.1542\/peds.110.2.e17","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:17:55Z","timestamp":1092442675000},"page":"e17-e17","source":"Crossref","is-referenced-by-count":25,"title":["Kawasaki Disease Before Kawasaki at Tokyo University Hospital"],"prefix":"10.1542","volume":"110","author":[{"given":"Noriko","family":"Shibuya","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Sanno Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Children\u2019s Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"2021121006310773800_R1","unstructured":"Kawasaki T. Pediatric acute mucocutaneous lymph node syndrome: clinical observation of 50 cases [in Japanese]. Jpn J Allerg.1967;16:178\u2013222"},{"key":"2021121006310773800_R2","doi-asserted-by":"crossref","unstructured":"Yanagawa H, Yashiro M, Nakamura Y, Kawasaki T, Kato H. Results of 12 nation-wide epidemiological incidence surveys of Kawasaki disease in Japan. Arch Pediatr Adolesc Med.1995;149:779\u2013783","DOI":"10.1001\/archpedi.1995.02170200069011"},{"key":"2021121006310773800_R3","unstructured":"Fujikawa T. A case of Feer disease [in Japanese]. J Pediatr Pract.1953;28:281\u2013283"},{"key":"2021121006310773800_R4","doi-asserted-by":"crossref","unstructured":"von Muhlendahl KE. Dental amalgam and Feer disease. Eur J Pediatr.1995;154:585\u2013586","DOI":"10.1007\/BF02074842"},{"key":"2021121006310773800_R5","doi-asserted-by":"crossref","unstructured":"Burns CJ, Kushner IH, Bastian FJ, et al. Kawasaki disease: a brief history. Pediatrics.2000;106(2). Available at: http:\/\/www.pediatrics.org\/cgi\/content\/full\/106\/2\/e27","DOI":"10.1542\/peds.106.2.e27"},{"key":"2021121006310773800_R6","unstructured":"The Japan Kawasaki Disease Research Committee. Diagnostic Guideline of Kawasaki Disease [in Japanese]. 4th ed. Tokyo, Japan: The Japan Kawasaki Disease Research Committee; 1984"},{"key":"2021121006310773800_R7","doi-asserted-by":"crossref","unstructured":"Sato K. Clinical findings and epidemiology of Yersinia pseudotuberculosis infection, especially concerned with Izumi fever [in Japanese]. Kansenshogakuzasshi.1987;61:746\u2013762","DOI":"10.11150\/kansenshogakuzasshi1970.61.746"},{"key":"2021121006310773800_R8","doi-asserted-by":"crossref","unstructured":"Kawasaki T, Kosaki F, Okawa S, et al. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics.1974;54:271\u2013276","DOI":"10.1542\/peds.54.3.271"},{"key":"2021121006310773800_R9","unstructured":"Izumi S, Yagasaki T, Sugishita N. A recent epidemic of scarlet fever-like exanthematous febrile disease in Kanazawa City [in Japanese]. Jika Zasshi.1929;347:667\u2013689, 348:862\u2013882"},{"key":"2021121006310773800_R10","doi-asserted-by":"crossref","unstructured":"Sato K, Ouchi K, Taki M. Yersinia pseudotuberculosis infection in children, resembling Izumi fever and Kawasaki syndrome. Pediatr Infect Dis.1983;2:123\u2013126","DOI":"10.1097\/00006454-198303000-00011"},{"key":"2021121006310773800_R11","unstructured":"Baba K, Takeda N, Tanaka M. Cases of Yersinia pseudotuberculosis infection having diagnostic criteria of Kawasaki disease. Contrib Microbiol Immunol.1991;12:292\u2013296"},{"key":"2021121006310773800_R12","unstructured":"The Japan Kawasaki Disease Research Committee of Ministry of Health and Welfare. The 16th Nationwide Survey on Kawasaki Disease in 1999\u20132000 [in Japanese]. Tokyo, Japan: The Japan Kawasaki Disease Research Committee of Ministry of Health and Welfare; 2001"},{"key":"2021121006310773800_R13","unstructured":"Sakurai K. A case of mucocutaneous-ocular syndrome [in Japanese]. Jpn J Pediatr.1954;7:787\u2013790"},{"key":"2021121006310773800_R14","unstructured":"Tanaka T. Izumi fever in Fukuoka city [in Japanese]. J Pediatr Pract.1954;17:344\u2013347"},{"key":"2021121006310773800_R15","doi-asserted-by":"crossref","unstructured":"Long SS. Fifty years ago in journal of pediatrics. J Pediatr.1999;134:171","DOI":"10.1016\/S0022-3476(99)70440-3"},{"key":"2021121006310773800_R16","doi-asserted-by":"crossref","unstructured":"Fanney GC Jr. Erythema multiforme exudativum: Stevens-Johnson syndrome. Cardiovascular and central nervous system involvement. J Pediatr.1949;34:195\u2013203","DOI":"10.1016\/S0022-3476(49)80171-5"},{"key":"2021121006310773800_R17","doi-asserted-by":"crossref","unstructured":"Landing BH, Larson JE. Are infantile periarteritis nodosa with coronary artery involvement and fatal mucocutaneous lymph node syndrome the same? Comparison of 20 patients from North America with patients from Hawaii and Japan. Pediatrics.1977;59:651\u2013662","DOI":"10.1542\/peds.59.5.651"},{"key":"2021121006310773800_R18","doi-asserted-by":"crossref","unstructured":"Shulman ST. The first reported case of Kawasaki disease?J Pediatr.1999;135:532","DOI":"10.1016\/S0022-3476(99)70187-3"},{"key":"2021121006310773800_R19","doi-asserted-by":"crossref","unstructured":"Konishi N, Baba K, Abe J, et al. A case of Kawasaki disease with coronary artery aneurysms documenting Yersinia pseudotuberculosis infection. Acta Paediatr.1997;86:661\u2013664","DOI":"10.1111\/j.1651-2227.1997.tb08952.x"},{"key":"2021121006310773800_R20","unstructured":"Tomita S, Fujimoto T, Kato H. Antibody titers against Yersinia pseudotuberculosis in Kawasaki disease patients [in Japanese]. J Jpn Pediatr Soc.1987;91:1485\u20131487"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/110\/2\/e17\/1116037\/pe0802000e17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/110\/2\/e17\/1116037\/pe0802000e17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T05:34:46Z","timestamp":1682746486000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/110\/2\/e17\/64329\/Kawasaki-Disease-Before-Kawasaki-at-Tokyo"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,8,1]]},"published-print":{"date-parts":[[2002,8,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.110.2.e17","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,1]]}}}