{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:40:44Z","timestamp":1791027644769,"version":"4.1.0"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:p>Objective. To investigate the behavioral changes induced by moderate hyperbilirubinemia in the otherwise healthy, untreated newborn infant.<\/jats:p><jats:p>Methods. Fifty term neonates (23 boys) with untreated moderate hyperbilirubinemia (median: 14.3 mg\/dL; range: 13.2\u201320 mg\/dL) and 50 matched control subjects with lower bilirubin concentrations (median: 9.1 mg\/dL; range: 5.3\u201312 mg\/dL) were administered the Brazelton Neonatal Behavioral Scale at 87 hours of life (range: 72\u2013110 hours). A subgroup analysis was also performed at 104 hours of life (range: 96\u2013134 hours) and at 3 weeks of age.<\/jats:p><jats:p>Results. At the first examination, all behavioral clusters were significantly altered in the group with moderate hyperbilirubinemia. The visual and auditory capabilities of the hyperbilirubinemic infant were especially compromised. Although social-interactive cluster scores significantly correlated both with serum bilirubinemia and birth weight, the former accounted for 8.7% of the variance and the latter accounted for only 4.7%. The moderate hyperbilirubinemia neonates\u2019 scores also showed a negative correlation with the autonomic system and more frequent presence of tremors. After 24 hours, a decrease in serum bilirubin within the moderate hyperbilirubinemic group was associated with improved scores. At 3 weeks of age, the behavioral assessment of the 2 groups did not show significant differences.<\/jats:p><jats:p>Conclusions. Untreated moderate hyperbilirubinemia is associated with a transient and apparently reversible alteration of neonatal behavior, particularly in the social-interactive area.<\/jats:p>","DOI":"10.1542\/peds.110.4.e50","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:17:55Z","timestamp":1092442675000},"page":"e50-e50","source":"Crossref","is-referenced-by-count":24,"title":["Moderate Hyperbilirubinemia Induces a Transient Alteration of Neonatal Behavior"],"prefix":"10.1542","volume":"110","author":[{"given":"Roberto","family":"Paludetto","sequence":"first","affiliation":[{"name":"From the Division of Neonatology, Department of Pediatrics \u201cFederico II\u201d of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Mansi","sequence":"additional","affiliation":[{"name":"From the Division of Neonatology, Department of Pediatrics \u201cFederico II\u201d of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Raimondi","sequence":"additional","affiliation":[{"name":"From the Division of Neonatology, Department of Pediatrics \u201cFederico II\u201d of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Romano","sequence":"additional","affiliation":[{"name":"From the Division of Neonatology, Department of Pediatrics \u201cFederico II\u201d of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Crivaro","sequence":"additional","affiliation":[{"name":"From the Division of Neonatology, Department of Pediatrics \u201cFederico II\u201d of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Bussi","sequence":"additional","affiliation":[{"name":"From the Division of Neonatology, Department of Pediatrics \u201cFederico II\u201d of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"D\u2019Ambrosio","sequence":"additional","affiliation":[{"name":"From the Division of Neonatology, Department of Pediatrics \u201cFederico II\u201d of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"2021121006401982700_R1","unstructured":"Maisels MJ. 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