{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:07:42Z","timestamp":1761394062517,"version":"3.40.5"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:p>Rotavirus gastroenteritis continues to cause substantial morbidity and mortality worldwide, despite widespread breastfeeding and use of oral rehydration therapy. This burden of disease indicates that an effective, safe rotavirus vaccine is needed, and in 1998 the first rhesus-human reassortant rotavirus tetravalent vaccine, Rotashield, was licensed in the United States. However, the recommendations for its use were withdrawn in 1999 because of the recognition of an uncommon but serious adverse event, intussusception. A workshop in September 2001 was held to review the subsequent developments and research regarding this association, the proceedings of which are summarized here. Although the pathogenesis of this association remains unknown, epidemiologic evidence supports a causal relationship, with a population attributable risk of \u223c1 per 10 000 (range of 1 in 5000 to 1 in 12 000) vaccine recipients. Whether this association will exist with other candidate rotavirus vaccine strains and whether the attributable risk for intussusception would be similar in other populations administered this vaccine are unclear. Because perceptions of vaccine safety derive from the relative disease burdens of the illness prevented and adverse events induced, the acceptance of rare adverse events may vary substantially in different settings. Nevertheless, a continuing consensus on the need for a safe and effective vaccine to prevent rotavirus gastroenteritis, especially for use in developing countries, exists.<\/jats:p>","DOI":"10.1542\/peds.110.6.e67","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T18:31:03Z","timestamp":1310668263000},"page":"e67-e67","source":"Crossref","is-referenced-by-count":118,"title":["Intussusception, Rotavirus, and Oral Vaccines: Summary of a Workshop"],"prefix":"10.1542","volume":"110","author":[{"given":"Georges","family":"Peter","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Brown Medical School, and Division of Pediatric Infectious Diseases, Rhode Island Hospital, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"Myers","sequence":"additional","affiliation":[{"name":"National Vaccine Program Office, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2002,12,1]]},"reference":[{"key":"2021121006355514800_R1","doi-asserted-by":"crossref","unstructured":"Kombo LA, Gerber MA, Pickering LK, Atreya CD, Breiman RF. Intussusception, infection, and immunization: summary of a workshop on rotavirus. Pediatrics.2001;108(8). Available at: http:\/\/www.pediatrics.org\/cgi\/content\/full\/108\/8\/e37","DOI":"10.1542\/peds.108.2.e37"},{"key":"2021121006355514800_R2","unstructured":"World Health Organization. Report of the meeting on future directions for rotavirus in developing countries; February 9\u201311, 2000; Geneva, Switzerland. WHO\/V&B 00.23"},{"key":"2021121006355514800_R3","unstructured":"Institute of Medicine. New Vaccine Development: Establishing Priorities; Volume II, Diseases of Importance in Developing Countries. Washington, DC: National Academy Press; 1986"},{"key":"2021121006355514800_R4","unstructured":"Centers for Diseases Control and Prevention. Rotavirus vaccine for the prevention of rotavirus gastroenteritis among children: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep.1999;48:1\u201323"},{"key":"2021121006355514800_R5","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, Committee on Infectious Diseases. Prevention of rotavirus disease: guidelines for use of rotavirus vaccine. Pediatrics.1998;102:1483\u20131491","DOI":"10.1542\/peds.102.6.1483"},{"key":"2021121006355514800_R6","doi-asserted-by":"crossref","unstructured":"Tucker AW, Haddix AC, Bresse JS, Holman RC, Parashar UD, Glass RI. Cost-effectiveness analysis of a rotavirus immunization program in the Untied States. JAMA.1998;279:1371\u20131376","DOI":"10.1001\/jama.279.17.1371"},{"key":"2021121006355514800_R7","unstructured":"Smith J, Haddix A, Teutsch S, Glass RI. Cost effectiveness analysis of a rotavirus immunization program for the United States. Pediatrics.1995;96:609\u2013615"},{"key":"2021121006355514800_R8","doi-asserted-by":"crossref","unstructured":"Velaquez FR, Matson DO, Calva JJ, et al. Rotavirus infection in infants as protection against subsequent infections. N Engl J Med.1996;335:1022\u20131028","DOI":"10.1056\/NEJM199610033351404"},{"key":"2021121006355514800_R9","unstructured":"Veskari T, Karvonen A, Pang X-L, Forrest BD. Neonatal administration of rhesus rotavirus tetravalent (RRV-TV) vaccine [abstract]. Clin Infect Dis.1999;29:1075A"},{"key":"2021121006355514800_R10","unstructured":"Staat MA, Roberts NE, Bernstein DI. Epidemiology and clinical features of intussusception in children &lt;24 months of age in Hamilton County, Ohio [abstract]. Pediatr Res.2000;49:242A"},{"key":"2021121006355514800_R11","doi-asserted-by":"crossref","unstructured":"Moser CA, Dolfi DV, DiVietro DL, Heaton PA, Offit PA, Clark HF. Hypertrophy, hyperplasia, and infectious virus in gut-associated lymphoid tissue of mice after oral inoculation with simian-human or bovine-human reassortant rotaviruses. J Infect Dis.2001;183:1108\u20131111","DOI":"10.1086\/319294"},{"key":"2021121006355514800_R12","doi-asserted-by":"crossref","unstructured":"Nakagomi T. Rotavirus infection and intussusception: a view from retrospect. Microbiol Immunol.2000;44:619\u2013628","DOI":"10.1111\/j.1348-0421.2000.tb02542.x"},{"key":"2021121006355514800_R13","doi-asserted-by":"crossref","unstructured":"Murphy TV, Gargiullo PM, Massoudi MS, et al. Intussusception among infants given an oral rotavirus vaccine. N Engl J Med.2001;344:564\u2013572","DOI":"10.1056\/NEJM200102223440804"},{"key":"2021121006355514800_R14","doi-asserted-by":"crossref","unstructured":"Kramarz P, France EK, Destefano F, et al. Population-based study of rotavirus vaccination and intussusception. Pediatr Infect Dis J.2001;20:410\u2013416","DOI":"10.1097\/00006454-200104000-00008"},{"key":"2021121006355514800_R15","doi-asserted-by":"crossref","unstructured":"Chang HG, Smith PF, Ackelsberg J, Morse DL, Glass RI. Intussusception, rotavirus diarrhea, and rotavirus vaccine use among children in New York State. Pediatrics.2001;108:54\u201360","DOI":"10.1542\/peds.108.1.54"},{"key":"2021121006355514800_R16","doi-asserted-by":"crossref","unstructured":"Simonsen L, Morens D, Elixhauser A, Gerber M, Van Raden M, Blackwelder W. Effect of rotavirus vaccination programme on trends in admission of infants to hospital for intussusception. Lancet.2001;358:1224\u20131229","DOI":"10.1016\/S0140-6736(01)06346-2"},{"key":"2021121006355514800_R17","doi-asserted-by":"crossref","unstructured":"Verstraeten T, Baughman AL, Cadwell B, Zanardi L, Haber P, Chen RT. Enhancing vaccine safety surveillance: a capture-recapture analysis of intussusception after rotavirus vaccination. Am J Epidemiol.2001;154:1006\u20131012","DOI":"10.1093\/aje\/154.11.1006"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/110\/6\/e67\/1117207\/pe12020000h1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/110\/6\/e67\/1117207\/pe12020000h1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T15:11:45Z","timestamp":1639149105000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/110\/6\/e67\/64439\/Intussusception-Rotavirus-and-Oral-Vaccines"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,1]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2002,12,1]]},"published-print":{"date-parts":[[2002,12,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.110.6.e67","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2002,12,1]]}}}