{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:41:21Z","timestamp":1790624481930,"version":"4.1.0"},"reference-count":18,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:p>Objectives. To characterize the clinical features, results of diagnostic testing, and treatment outcomes for children and adolescents with rumination syndrome.<\/jats:p>\n               <jats:p>Methods. Review of the medical records for all 147 patients ages 5 to 20 diagnosed with rumination syndrome at our institution between 1975 and 2000. Data are presented as mean \u00b1 the standard error of the mean.<\/jats:p>\n               <jats:p>Results. Sixty-eight percent were female. Age at diagnosis was 15.0 \u00b1 0.3 years. Symptom duration before diagnosis was 2.2 \u00b1 0.3 years, 73% missed school\/work, and 46% had been hospitalized because of symptoms. Before diagnosis, 16 (11%) underwent surgery for evaluation or management of symptoms. Twenty-four (16%) had psychiatric disorders; 3.4% had anorexia or bulimia nervosa. All patients described postprandial regurgitation after almost every meal (2.7 \u00b1 0.1 meals per day). Weight loss was described by 42.2% (median: 7 kg). Additional symptoms included: abdominal pain, 38%; constipation, 21%; nausea, 17%; and diarrhea, 8%. Structural studies were normal. Gastric emptying of solids at 4 hours was delayed in 26 of 56 patients. Esophageal pH testing in 24 patients showed reflux\/regurgitation in 54%. Gastroduodenal manometry in 65 patients showed characteristic rumination-waves in 40%. Outcome data (at median follow-up 10 months) were available for 54 patients. Symptoms resolved in 16 (30%) and improved in 30 (56%).<\/jats:p>\n               <jats:p>Conclusions. Recognition of the clinical features of rumination syndrome in children and adolescents is essential; the diagnosis is often delayed and associated with morbidity. Extensive diagnostic testing is unnecessary. Early behavioral therapy is advocated, and patient outcomes are generally favorable.<\/jats:p>","DOI":"10.1542\/peds.111.1.158","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:43:47Z","timestamp":1092444227000},"page":"158-162","source":"Crossref","is-referenced-by-count":165,"title":["Rumination Syndrome in Children and Adolescents: Diagnosis, Treatment, and Prognosis"],"prefix":"10.1542","volume":"111","author":[{"given":"Heather J.","family":"Chial","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program"},{"name":"Department of Clinical Health Psychology, Mayo Clinic Rochester, Rochester, Minnesota"},{"name":"McGill University Health Center, Montreal Children\u2019s Hospital, Division of Gastroenterology and Nutrition, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program"},{"name":"Department of Clinical Health Psychology, Mayo Clinic Rochester, Rochester, Minnesota"},{"name":"McGill University Health Center, Montreal Children\u2019s Hospital, Division of Gastroenterology and Nutrition, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Clinical Health Psychology, Mayo Clinic Rochester, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Litzinger","sequence":"additional","affiliation":[{"name":"Department of Clinical Health Psychology, Mayo Clinic Rochester, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Perrault","sequence":"additional","affiliation":[{"name":"McGill University Health Center, Montreal Children\u2019s Hospital, Division of Gastroenterology and Nutrition, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"2021120821092292100_R1","doi-asserted-by":"crossref","unstructured":"Clouse RE, Richter JE, Heading RC, Janssens J, Wilson JA. 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J Pediatr Gastroenterol Nutr.1998;27:596\u2013598","DOI":"10.1097\/00005176-199811000-00019"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/111\/1\/158\/1005870\/pe0103000158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/111\/1\/158\/1005870\/pe0103000158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T01:09:17Z","timestamp":1639012157000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/111\/1\/158\/28514\/Rumination-Syndrome-in-Children-and-Adolescents"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,1]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,1,1]]},"published-print":{"date-parts":[[2003,1,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.111.1.158","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,1]]}}}