{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:08:38Z","timestamp":1772759318890,"version":"3.50.1"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:p>Objective. To examine changes in grip force during pamidronate therapy in children and adolescents with severe osteogenesis imperfecta (OI).<\/jats:p>\n               <jats:p>Methods. Maximal isometric grip force of the nondominant hand was prospectively determined in 42 patients (age at the start of the study: 7.3\u201315.9 years; 18 girls) with severe forms of OI. Patients were treated with intravenous pamidronate infusions given in 4 monthly cycles, each cycle consisting of 3 infusions (1 mg pamidronate\/kg body wt) on 3 successive days.<\/jats:p>\n               <jats:p>Results. At the start of pamidronate therapy, grip force was low compared with age-specific reference data (age z score mean \u00b1 standard deviation: \u22122.7 \u00b1 2.1) but was normal for weight (weight z score: \u22120.1 \u00b1 1.8). Four months after the first pamidronate infusion cycle, grip force had increased significantly, whether related to age (age z score: \u22122.0 \u00b1 1.8) or to weight (weight z score: 0.6 \u00b1 1.5). At 2 years after the start of therapy, grip force z scores were not significantly different from the 4-month results.<\/jats:p>\n               <jats:p>Conclusions. Maximal isometric grip force markedly increases after a single cycle of intravenous pamidronate in children with severe forms of OI, and this gain in grip force is maintained for at least 2 years.<\/jats:p>","DOI":"10.1542\/peds.111.5.e601","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:43:47Z","timestamp":1092444227000},"page":"e601-e603","source":"Crossref","is-referenced-by-count":54,"title":["Rapid Increase in Grip Force After Start of Pamidronate Therapy in Children and Adolescents With Severe Osteogenesis Imperfecta"],"prefix":"10.1542","volume":"111","author":[{"given":"Kathleen","family":"Montpetit","sequence":"first","affiliation":[{"name":"From the Shriners Hospital, McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Plotkin","sequence":"additional","affiliation":[{"name":"From the Shriners Hospital, McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Rauch","sequence":"additional","affiliation":[{"name":"From the Shriners Hospital, McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"From the Shriners Hospital, McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Cloutier","sequence":"additional","affiliation":[{"name":"From the Shriners Hospital, McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Rabzel","sequence":"additional","affiliation":[{"name":"From the Shriners Hospital, McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis H.","family":"Glorieux","sequence":"additional","affiliation":[{"name":"From the Shriners Hospital, McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2003,5,1]]},"reference":[{"key":"2021121003371151800_R1","doi-asserted-by":"crossref","unstructured":"Sillence DO, Senn A, Danks DM. 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