{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:00:03Z","timestamp":1761487203003,"version":"3.40.5"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,1]]},"abstract":"<jats:p>A cluster of 5 family members, a mother and 4 children, were hospitalized for severe group A Streptococcus (GAS) pneumonia. Three family members had complications: sepsis (1), empyema (2), and a sterile parapneumonic effusion (1). Two additional family members had symptoms of upper respiratory tract infection, and 1 was hospitalized for these symptoms. GAS was isolated from the blood of 1 patient, the pleural fluid of 2 patients, and the oropharynx of 6 patients. Pulsed field gel electrophoresis testing revealed an identical deoxyribonucleic acid pattern in all 7 isolates. Genotyping revealed the speA gene and serotyping the T-1, M-1 serotype in all isolates. This family cluster of invasive GAS disease is the largest reported to date, with an attack rate of 41.7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease.<\/jats:p>","DOI":"10.1542\/peds.112.1.e61","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:43:47Z","timestamp":1092444227000},"page":"e61-e65","source":"Crossref","is-referenced-by-count":22,"title":["A Family Cluster of Five Cases of Group A Streptococcal Pneumonia"],"prefix":"10.1542","volume":"112","author":[{"given":"Sumita","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"World Health Organization Collaborating Center for Reference and Research on Streptococci, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benigno","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio"},{"name":"Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Salata","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Palavecino","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandy C.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2003,7,1]]},"reference":[{"key":"2021121003383156700_R1","doi-asserted-by":"crossref","unstructured":"Eriksson BK, Andersson J, Holm SE, Norgren M. 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