{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:39:46Z","timestamp":1789940386016,"version":"4.0.1"},"reference-count":33,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:p>Objective. Human T-cell lymphotropic virus type I (HTLV-I) infection in childhood is believed to play an important role in risk for adult T-cell leukemia\/lymphoma. Although HTLV-I is known to be associated with infective dermatitis in childhood, other HTLV-I-associated morbidity in children has not been well studied. We sought to determine the HTLV-I-associated health effects in Jamaican children.<\/jats:p>\n               <jats:p>Methods. We compared incidence rates of several health outcomes in 28 HTLV-I-infected and 280 uninfected children clinically followed from age 6 weeks to a maximum of 10 years. Cox proportional hazards regression analysis was used to analyze these prospectively collected data, adjusting for confounding effects of other variables as necessary.<\/jats:p>\n               <jats:p>Results. HTLV-I-infected children had significantly higher incidence rates of seborrheic dermatitis (rate ratio [RR] = 4.8, 95% confidence interval [CI] = 1.9\u201312.5), eczema (RR = 3.1, CI = 1.2\u20137.9) and persistent hyperreflexia (RR = 3.7, CI = 1.6\u20138.2). Additionally, HTLV-I infected children had increased rates of severe anemia (RR = 2.5, CI = 0.8\u20137.9) and abnormal lymphocytes (RR = 2.4, CI = 0.8\u20137.6) that were of borderline statistical significance.<\/jats:p>\n               <jats:p>Conclusions. Our study suggests that HTLV-I-associated skin diseases of childhood may include seborrheic dermatitis and eczema. Additionally, these data suggest that persistent hyperreflexia of the lower limbs may be an early sign of HTLV-I-associated neurologic involvement in children. Expansion and continued clinical observation of this cohort would be valuable.<\/jats:p>","DOI":"10.1542\/peds.112.2.e136","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:43:47Z","timestamp":1092444227000},"page":"e136-e142","source":"Crossref","is-referenced-by-count":33,"title":["A Cohort Study of Health Effects of Human T-Cell Lymphotropic Virus Type I Infection in Jamaican Children"],"prefix":"10.1542","volume":"112","author":[{"given":"Elizabeth M.","family":"Maloney","sequence":"first","affiliation":[{"name":"Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Z.","family":"Wiktor","sequence":"additional","affiliation":[{"name":"Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Palmer","sequence":"additional","affiliation":[{"name":"Pathology Department, University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley","family":"Cranston","sequence":"additional","affiliation":[{"name":"Pathology Department, University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest J.","family":"Pate","sequence":"additional","affiliation":[{"name":"Pathology Department, University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Cohn","sequence":"additional","affiliation":[{"name":"Research Triangle Institute, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Triangle Institute, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendell","family":"Miley","sequence":"additional","affiliation":[{"name":"Scientific Applications International Incorporated, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, Maryland"},{"name":"Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Blattner","sequence":"additional","affiliation":[{"name":"Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrie","family":"Hanchard","sequence":"additional","affiliation":[{"name":"Pathology Department, University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2003,8,1]]},"reference":[{"key":"2021121003374246500_R1","unstructured":"Takatsuki K, Uchiyama T, Sagawa K, Yodoi J. 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