{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:25:01Z","timestamp":1760887501076,"version":"3.40.5"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:p>Objective. Systemic infection affects one quarter of preterm infants. Defense from infection is in part mediated by the cytokine interleukin-6 (IL-6). We tested the hypothesis that the IL-6 \u2212174 GG genotype, associated with lower IL-6 response to inflammation, is also associated with the development of septicemia in preterm infants.<\/jats:p>\n               <jats:p>Methods. The study group comprised 157 infants who were born at \u226432 weeks. Genotype distribution (34% [54] GG, 46% [72] GC, 20% [31] CC) and C allele frequency (0.43; 95% confidence interval [CI]: 0.37\u20130.48) were similar to the UK adult population. Among the patients who developed bacterially confirmed septicemia (n = 51 [33%]), there was a significantly higher prevalence of the IL-6 \u2212174 GG genotype than that observed in those who did not develop infection (47% vs 28% for GG: odds ratio [OR]: 2.3; 95% CI: 1.1\u20134.5). This association remained statistically significant (OR: 2.7; 95% CI: 1.2\u20136.3) after multiple binary logistic regression adjustment for other significant predictors of the development of septicemia. Late infection alone was similarly associated with GG genotype (septicemia 47% vs no septicemia 29% for GG: OR: 2.2; 95% CI: 1.1\u20134.3).<\/jats:p>\n               <jats:p>Conclusions. Variation in the IL-6 gene seems to influence the defense against bacterial pathogens in the very preterm infant.<\/jats:p>","DOI":"10.1542\/peds.112.4.800","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:43:47Z","timestamp":1092444227000},"page":"800-803","source":"Crossref","is-referenced-by-count":61,"title":["Is Interleukin-6 \u2212174 Genotype Associated With the Development of Septicemia in Preterm Infants?"],"prefix":"10.1542","volume":"112","author":[{"given":"David","family":"Harding","sequence":"first","affiliation":[{"name":"Department of Child Health, University of Bristol, Bristol, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbir","family":"Dhamrait","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Millar","sequence":"additional","affiliation":[{"name":"Lung Research Group, University of Bristol Medical School, Southmead Hospital, Bristol, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Humphries","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Marlow","sequence":"additional","affiliation":[{"name":"School of Human Development, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Whitelaw","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, University of Bristol Medical School, Southmead Hospital, Bristol, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"2021121003415195500_R1","doi-asserted-by":"crossref","unstructured":"Stoll BJ, Gordon T, Korones SB, et al. 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