{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:14:52Z","timestamp":1787022892223,"version":"build-2736575974"},"reference-count":44,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:p>Objectives. To determine the sensitivity of the bacillus Calmette-Gue\u0301rin (BCG) scar as an indicator of previous vaccination and to ascertain the tuberculin skin test (TST) response in infancy after vaccination in a community from an area hyperendemic for tuberculosis (TB).<\/jats:p>\n                  <jats:p>Methods. In a birth cohort of healthy term infants from Lima, Peru, a single dose of BCG vaccine was administered within the first month of life. Scar formation was assessed biweekly during the first 6 months and again at 3 years after vaccination. TST response was evaluated 6 months after vaccination.<\/jats:p>\n                  <jats:p>Results. Six months after vaccination, 99% (68) of the newborns exhibited a BCG scar (&amp;gt;2 mm). Scar size did not differ by sex, birth weight, age at vaccination, or nutritional status in the first 2 months. Eighty percent of the participants were found 3 years after vaccination, and all of them had a BCG scar. Mean TST reaction size 6 months after vaccination was 2.9 \u00b1 0.3 mm. No association was found between sex or age at BCG vaccination and TST size. Only 3 children had a TST &amp;gt;10 mm, and the 3 had a TB contact at home.<\/jats:p>\n                  <jats:p>Conclusions. The BCG scar was a sensitive indicator of vaccination status up to 3 years after the administration of the vaccine in the first month of life. Although nearly a quarter of the children had a TST response &amp;gt;5 mm 6 months after vaccination, TST reactions &amp;gt;10 mm did not occur in the absence of exposure to a person with tuberculosis. A cutoff of 10 mm should be used for disease control purposes in people who are born in countries where TB is endemic.<\/jats:p>","DOI":"10.1542\/peds.112.4.e298","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T20:43:47Z","timestamp":1092429827000},"page":"e298-e298","source":"Crossref","is-referenced-by-count":54,"title":["A Prospective Study of Bacillus Calmette-Gue\u0301rin Scar Formation and Tuberculin Skin Test Reactivity in Infants in Lima, Peru"],"prefix":"10.1542","volume":"112","author":[{"given":"Eunice M.","family":"Santiago","sequence":"first","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Lawson","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Gillenwater","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheela","family":"Kalangi","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u0301s G.","family":"Lescano","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"},{"name":"Global Emerging Infection System, Naval Medical Research Center Detachment, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Du Quella","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Cummings","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Torres","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[{"name":"Asociacio\u0301n Bene\u0301fica Proyectos en Informa\u0301tica, Salud, Medicina y Agricultura, Lima, Peru"},{"name":"Department of International Health, Johns Hopkins University Bloomberg School of Hygiene and Public Health, Baltimore, Maryland"},{"name":"Universidad Peruana Cayetano Heredia, School of Public Health and Health Administration and School of Medicine, Department of Pathology, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"2021121003431306600_R1","doi-asserted-by":"crossref","unstructured":"Espinal MA, Laszlo A, Simonsen L, et al. 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