{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:15:25Z","timestamp":1788682525786,"version":"build-2803163510"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:p>Objective. To monitor clinical and microbiologic features including antimicrobial susceptibility and serogroup distribution of invasive infections caused by Streptococcus pneumoniae among children before and after the introduction of routine administration of the 7-valent pneumococcal conjugate vaccine (PCV7).<\/jats:p>\n               <jats:p>Design. A 9-year (January 1, 1994 through December 31, 2002) prospective surveillance study of all invasive pneumococcal infections in children.<\/jats:p>\n               <jats:p>Patients. Infants and children cared for at 8 children\u2019s hospitals in the United States with culture-proven invasive infections caused by S pneumoniae.<\/jats:p>\n               <jats:p>Results. When compared with the mean of the years 1994 to 2000, the annual number of invasive pneumococcal infections for children \u226424 months of age declined 58% in 2001 and 66% in 2002. If only the serogroups in the PCV7 are considered, the number of cases in children \u226424 months old declined 63% and 77% in 2001 and 2002, respectively. The greatest decrease was observed for serogroup-14 isolates. The number of isolates in nonvaccine serogroups increased 28% in 2001 and 66% in 2002 for children \u226424 months old. Nonvaccine serogroup-15 and -33 isolates had the greatest increase in number. The proportion of all isolates nonsusceptible to penicillin increased yearly from 1994 to 2000, reached a plateau in 2001 at 45%, and declined to 33% in 2002. Decrease in nonsusceptibility to penicillin occurred entirely in the isolates with penicillin minimum inhibitory concentration \u22652 \u03bcg\/mL. Nonsusceptibility to penicillin increased slightly among nonvaccine-serotype isolates. Most infections after at least 2 doses of PCV7 were caused by nonvaccine-serotype isolates.<\/jats:p>\n               <jats:p>Conclusions. Since the introduction of the PCV7, the number of invasive pneumococcal infections caused by vaccine-serogroup isolates among 8 US children\u2019s hospitals has decreased &amp;gt;75% among children \u226424 months old. In addition, penicillin resistance decreased in 2002 for the first time since our surveillance began in 1993\u20131994. However, we have noted that replacement may be developing with serogroups 15 and 33. Furthermore, penicillin resistance seems to be increasing among nonvaccine serogroups. Surveillance must be continued to detect the emergence of changes in the distribution of serotypes as well as antibiotic susceptibility.<\/jats:p>","DOI":"10.1542\/peds.113.3.443","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:53:04Z","timestamp":1092444784000},"page":"443-449","source":"Crossref","is-referenced-by-count":330,"title":["Decrease of Invasive Pneumococcal Infections in Children Among 8 Children\u2019s Hospitals in the United States After the Introduction of the 7-Valent Pneumococcal Conjugate Vaccine"],"prefix":"10.1542","volume":"113","author":[{"given":"Sheldon L.","family":"Kaplan","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Sections of the Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Edward O","family":"Mason","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Sections of the Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen R.","family":"Wald","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon E.","family":"Schutze","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Q.","family":"Tan","sequence":"additional","affiliation":[{"name":"Northwestern University Medical School, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill A.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"University of Southern California School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence B.","family":"Givner","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Yogev","sequence":"additional","affiliation":[{"name":"Northwestern University Medical School, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Barson","sequence":"additional","affiliation":[{"name":"Ohio State University College of Medicine and Public Health, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"2021121006124405800_R1","unstructured":"Peter G, Klein JO. Streptococcus pneumoniae. In SS Long, LK Pickering, CG Prober, eds. Principles and Practice of Pediatric Infectious Diseases. New York, NY: Elsever Science; 2003"},{"key":"2021121006124405800_R2","doi-asserted-by":"crossref","unstructured":"Schuchat A, Robinson K, Wenger JD, et al. Bacterial meningitis in the United States in 1995. N Engl J Med.1997;337:970\u2013976","DOI":"10.1056\/NEJM199710023371404"},{"key":"2021121006124405800_R3","doi-asserted-by":"crossref","unstructured":"Black S, Shinefield H, Fireman B, et al. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis J.2000;19:187\u2013195","DOI":"10.1097\/00006454-200003000-00003"},{"key":"2021121006124405800_R4","doi-asserted-by":"crossref","unstructured":"Black SB, Shinefield HR, Hansen J, et al. Postlicensure evaluation of the effectiveness of seven valent pneumococcal conjugate vaccine. 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Wayne, PA: National Committee for Clinical Laboratory Standards; 2003;44\u201346"},{"key":"2021121006124405800_R8","doi-asserted-by":"crossref","unstructured":"Lin PL, Michaels MG, Janosky J, Ortenzo M, Wald ER, Mason EO Jr. Incidence of invasive pneumococcal disease in children 3 to 36 months of age at a tertiary care pediatric center 2 years after licensure of the pneumococcal conjugate vaccine. Pediatrics.2003;111:896\u2013899","DOI":"10.1542\/peds.111.4.896"},{"key":"2021121006124405800_R9","unstructured":"Hsu KK, Pelton SI, Heisey-Grove DM, Hashemi S, Klein JO. Serotype-specific surveillance for childhood invasive pneumococcal disease. Presented at: 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; September 28, 2002; San Diego, CA"},{"key":"2021121006124405800_R10","doi-asserted-by":"crossref","unstructured":"Tan TQ, Mason EO Jr, Wald ER, et al. Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae. 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