{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:42:13Z","timestamp":1793637733576,"version":"4.5.1"},"reference-count":14,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:p>Objective. Our purpose was to examine the significance of diffuse chorioamniotic hemosiderosis (DCH) on neonatal morbidity and mortality.<\/jats:p>\n               <jats:p>Methods. Using data from a retrospective case-control study, we analyzed 46 singleton placentas with DCH from infants who were delivered and\/or admitted to the neonatal intensive care unit of Kanagawa Children\u2019s Medical Center during 1987\u20132001 and 92 control placentas without DCH from infants of comparable gestational age, birth weight, and duration.<\/jats:p>\n               <jats:p>Results. Mean and standard deviation of gestational age and infants\u2019 birth weight at delivery from the DCH group were 27 \u00b1 3 weeks and 939 \u00b1 342 g, respectively. Macroscopically, the placentas with DCH were more likely to show old peripheral blood clots (46% in the DCH group vs 8% in control group), subchorionic hematoma (20% vs 1%), and circumvallation (13% vs 1%). Histologically, amniotic necrosis was significantly more frequent in the DCH group (63% vs 24%). Of the obstetric factors, incidence of recurrent episodes of vaginal bleeding (70% vs 11%), oligohydramnios (59% vs 8%), and chronic abruption-oligohydramnios sequence (57% vs 5%) were significantly higher in the DCH group. Of the neonatal factors, persistent pulmonary hypertension of the newborn (29% vs 8%) and dry lung and\/or pulmonary hypoplasia (20% vs 4%) were more common. However, respiratory distress syndrome was rare (15% vs 45%) in the DCH group. Neonatal death including stillbirth was increased in the DCH group but was not significant (24% vs 15%). Of infants who survived beyond day 28, chronic lung disease (CLD) was more frequent in the DCH group (51% vs 22%). The association of DCH, especially accompanied by amniotic necrosis, with CLD was still evident using likelihood ratio test.<\/jats:p>\n               <jats:p>Conclusion. DCH is closely associated with preterm delivery, pulmonary hypertension of the newborn, and dry lung syndrome and is a significant risk factor for CLD.<\/jats:p>","DOI":"10.1542\/peds.113.4.800","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:53:04Z","timestamp":1092444784000},"page":"800-805","source":"Crossref","is-referenced-by-count":52,"title":["Maternal, Neonatal, and Placental Features Associated With Diffuse Chorioamniotic Hemosiderosis, With Special Reference to Neonatal Morbidity and Mortality"],"prefix":"10.1542","volume":"113","author":[{"given":"Makiko","family":"Ohyama","sequence":"first","affiliation":[{"name":"Divisions of Neonatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Itani","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Obstetrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Goto","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Obstetrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieko","family":"Ijiri","sequence":"additional","affiliation":[{"name":"Obstetrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Obstetrics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2004,4,1]]},"reference":[{"key":"2021121006133876900_R1","doi-asserted-by":"crossref","unstructured":"Redline RW, Wilson-Costello D. 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