{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:41:22Z","timestamp":1775277682927,"version":"3.50.1"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:p>The metabolism of the basal ganglia was examined by using proton magnetic resonance spectroscopy in 5 neonates with severe hyperbilirubinemia. A decreased N-acetylaspartate\/choline ratio, indicating neuronal injury, and an abnormally high lactate\/N-acetylaspartate ratio were found only in the neonate with neonatal magnetic resonance imaging abnormalities and subsequent cerebral palsy.<\/jats:p>","DOI":"10.1542\/peds.114.1.291","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:53:04Z","timestamp":1092444784000},"page":"291-294","source":"Crossref","is-referenced-by-count":31,"title":["Cerebral Metabolism in Severe Neonatal Hyperbilirubinemia"],"prefix":"10.1542","volume":"114","author":[{"given":"Floris","family":"Groenendaal","sequence":"first","affiliation":[{"name":"Departments of Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen van der","family":"Grond","sequence":"additional","affiliation":[{"name":"Radiology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S. de","family":"Vries","sequence":"additional","affiliation":[{"name":"Departments of Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"2021121006505353000_R1","doi-asserted-by":"crossref","unstructured":"Hansen TW. Mechanisms of bilirubin toxicity: clinical implications. Clin Perinatol.\u20082002;29:765\u2013778","DOI":"10.1016\/S0095-5108(02)00053-2"},{"key":"2021121006505353000_R2","doi-asserted-by":"crossref","unstructured":"Rodrigues CM, Sola S, Brites D. Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons. Hepatology.\u20082002;35:1186\u20131195","DOI":"10.1053\/jhep.2002.32967"},{"key":"2021121006505353000_R3","doi-asserted-by":"crossref","unstructured":"Ives NK, Bolas NM, Gardiner RM. The effects of bilirubin on brain energy metabolism during hyperosmolar opening of the blood-brain barrier: an in vivo study using 31P nuclear magnetic resonance spectroscopy. Pediatr Res.\u20081989;26:356\u2013361","DOI":"10.1203\/00006450-198910000-00014"},{"key":"2021121006505353000_R4","doi-asserted-by":"crossref","unstructured":"Ives NK, Cox DW, Gardiner RM, Bachelard HS. The effects of bilirubin on brain energy metabolism during normoxia and hypoxia: an in vitro study using 31P nuclear magnetic resonance spectroscopy. Pediatr Res.\u20081988;23:569\u2013573","DOI":"10.1203\/00006450-198806000-00007"},{"key":"2021121006505353000_R5","doi-asserted-by":"crossref","unstructured":"Hoffman DJ, Zanelli SA, Kubin J, Mishra OP, Delivoria-Papadopoulos M. The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor\/ion channel complex in the brains of newborn piglets. Pediatr Res.\u20081996;40:804\u2013808","DOI":"10.1203\/00006450-199612000-00005"},{"key":"2021121006505353000_R6","unstructured":"Martich-Kriss V, Kollias SS, Ball WS Jr. MR findings in kernicterus. AJNR Am J Neuroradiol.\u20081995;16:819\u2013821"},{"key":"2021121006505353000_R7","doi-asserted-by":"crossref","unstructured":"Yokochi K. Magnetic resonance imaging in children with kernicterus. Acta Paediatr.\u20081995;84:937\u2013939","DOI":"10.1111\/j.1651-2227.1995.tb13796.x"},{"key":"2021121006505353000_R8","doi-asserted-by":"crossref","unstructured":"Groenendaal F, Veenhoven RH, van der Grond J, Jansen GH, Witkamp TD, de Vries LS. Cerebral lactate and N-acetyl-aspartate\/choline ratios in asphyxiated full-term neonates demonstrated in vivo using proton magnetic resonance spectroscopy. Pediatr Res.\u20081994;35:148\u2013151","DOI":"10.1203\/00006450-199402000-00004"},{"key":"2021121006505353000_R9","doi-asserted-by":"crossref","unstructured":"Robertson NJ, Cox IJ, Cowan FM, Counsell SJ, Azzopardi D, Edwards AD. Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res.\u20081999;46:287\u2013296","DOI":"10.1203\/00006450-199909000-00007"},{"key":"2021121006505353000_R10","doi-asserted-by":"crossref","unstructured":"van Straaten HL, Hille ET, Kok JH, Verkerk PH; Dutch NICU Neonatal Hearing Screening Working Group. Implementation of a nation-wide automated auditory brainstem response hearing screening programme in neonatal intensive care units. Acta Paediatr.\u20082003;92:332\u2013338","DOI":"10.1111\/j.1651-2227.2003.tb00555.x"},{"key":"2021121006505353000_R11","doi-asserted-by":"crossref","unstructured":"Roelants-van Rijn AM, van der Grond J, de Vries LS, Groenendaal F. Value of 1H-MRS using different echo times in neonates with cerebral hypoxia-ischemia. Pediatr Res.\u20082001;49:356\u2013362","DOI":"10.1203\/00006450-200103000-00009"},{"key":"2021121006505353000_R12","doi-asserted-by":"crossref","unstructured":"Hagberg B, Hagberg G, Olow I. The changing panorama of cerebral palsy in Sweden 1954\u20131970. II. Analysis of the various syndromes. Acta Paediatr Scand.\u20081975;64:193\u2013200","DOI":"10.1111\/j.1651-2227.1975.tb03821.x"},{"key":"2021121006505353000_R13","doi-asserted-by":"crossref","unstructured":"Roelants-van Rijn AM, Nikkels PGJ, Groenendaal F, et al. Neonatal diffusion-weighted MR imaging: relation with histopathology or follow-up MR examination. Neuropediatrics.\u20082001;32:286\u2013294","DOI":"10.1055\/s-2001-20403"},{"key":"2021121006505353000_R14","unstructured":"Patay Z, Robertson NJ, Cox IJ. Metabolic disorders in the neonate. In: Rutherford MA, ed. MRI of the Neonatal Brain. London, United Kingdom: W. B. Saunders; 2002:315\u2013348"},{"key":"2021121006505353000_R15","doi-asserted-by":"crossref","unstructured":"Gideon P, Henriksen O, Sperling B, et al. Early time course of N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline in the brain after acute stroke. A proton magnetic resonance spectroscopy study. Stroke.\u20081992;23:1566\u20131572","DOI":"10.1161\/01.STR.23.11.1566"},{"key":"2021121006505353000_R16","doi-asserted-by":"crossref","unstructured":"Houkin K, Kamada K, Kamiyama H, Iwasaki Y, Abe H, Kashiwaba T. Longitudinal changes in proton magnetic resonance spectroscopy in cerebral infarction. Stroke.\u20081993;24:1316\u20131321","DOI":"10.1161\/01.STR.24.9.1316"},{"key":"2021121006505353000_R17","doi-asserted-by":"crossref","unstructured":"Neil JJ, Shiran SI, McKinstry RC, et al. Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology.\u20081998;209:57\u201366","DOI":"10.1148\/radiology.209.1.9769812"},{"key":"2021121006505353000_R18","unstructured":"Forbes KP, Pipe JG, Bird R. Neonatal hypoxic-ischemic encephalopathy: detection with diffusion-weighted MR imaging. AJNR Am J Neuroradiol.\u20082000;21:1490\u20131496"},{"key":"2021121006505353000_R19","doi-asserted-by":"crossref","unstructured":"Rutherford MA, Pennock JM, Counsell SJ, et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics.\u20081998;102:323\u2013328","DOI":"10.1542\/peds.102.2.323"},{"key":"2021121006505353000_R20","doi-asserted-by":"crossref","unstructured":"Penn AA, Enzmann DR, Hahn JS, Stevenson DK. Kernicterus in a full term infant. Pediatrics.\u20081994;93:1003\u20131006","DOI":"10.1542\/peds.93.6.1003"},{"key":"2021121006505353000_R21","doi-asserted-by":"crossref","unstructured":"Harris MC, Bernbaum JC, Polin JR, Zimmerman R, Polin RA. Developmental follow-up of breastfed term and near-term infants with marked hyperbilirubinemia. Pediatrics.\u20082001;107:1075\u20131080","DOI":"10.1542\/peds.107.5.1075"},{"key":"2021121006505353000_R22","doi-asserted-by":"crossref","unstructured":"Johnson LH, Bhutani VK, Brown AK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr.\u20082002;140:396\u2013403","DOI":"10.1067\/mpd.2002.123098"},{"key":"2021121006505353000_R23","doi-asserted-by":"crossref","unstructured":"Hank\u00f8 E, Lindemann R, Hansen TWR. Spectrum of outcome in infants with extreme neonatal jaundice. Acta Paediatr.\u20082001;90:782\u2013785","DOI":"10.1080\/08035250120156"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/114\/1\/291\/1006328\/zpe00704000291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/114\/1\/291\/1006328\/zpe00704000291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T05:37:24Z","timestamp":1682746644000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/114\/1\/291\/64782\/Cerebral-Metabolism-in-Severe-Neonatal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,7,1]]},"published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.114.1.291","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,1]]}}}