{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:12:57Z","timestamp":1773753177799,"version":"3.50.1"},"reference-count":14,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:p>Objectives. To assess the prevalence and natural history of functional gastrointestinal disorders (FGIDs) in children using the Rome Criteria.<\/jats:p>\n               <jats:p>Methods. Thirteen primary care pediatricians were randomly selected from the Campania region of the Italian National Health Service. Each pediatrician completed a detailed FGID questionnaire on consecutive patients seen during a 3-month period. A total of 9660 patients aged birth to 12 years were enrolled prospectively during this 3-month period. Follow-up was performed at 1-, 3-, and 12-month intervals.<\/jats:p>\n               <jats:p>Results. A total of 194 children initially met strict criteria for at least 1 FGID. A total of 72 (37.1%) children had infant regurgitation, 26 (13.4%) had functional dyspepsia, 27 (13.9%) had irritable bowel syndrome, and 66 (34.1%) had functional constipation or other defecation disorders. All children who had a diagnosis of FGIDs were reevaluated at 1, 3, and 12 months to study the natural history of the illnesses. Additional evaluation revealed 5 children who had developed an organic diagnosis. Therefore, 5 (2.5%) of 194 children who had a diagnosis of FGIDs by the Rome criteria had a change in diagnosis to an organic disease during the study period, none of whom experienced permanent sequelae.<\/jats:p>\n               <jats:p>Conclusions. Of 194 children who received a prospective diagnosis of FGIDs using the Rome criteria, 97.5% continued to satisfy the diagnostic criteria or were improved at follow-up. The low prevalence of functional dyspepsia and irritable bowel syndrome in our population is most likely explained by the lack of adolescents in our sample.<\/jats:p>","DOI":"10.1542\/peds.114.1.73","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T00:53:04Z","timestamp":1092444784000},"page":"73-78","source":"Crossref","is-referenced-by-count":140,"title":["Functional Gastrointestinal Disorders in Children: An Italian Prospective Survey"],"prefix":"10.1542","volume":"114","author":[{"given":"Erasmo","family":"Miele","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Simeone","sequence":"additional","affiliation":[{"name":"Associazione Culturale Pediatri, Campania, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Marino","sequence":"additional","affiliation":[{"name":"Associazione Culturale Pediatri, Campania, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Novek","sequence":"additional","affiliation":[{"name":"Associazione Culturale Pediatri, Campania, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Staiano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"2021121006491637800_R1","unstructured":"Drossman DA, Thompson WG, Talley NJ, et al. 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