{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:43:42Z","timestamp":1774878222042,"version":"3.50.1"},"reference-count":21,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,1]]},"abstract":"<jats:p>Severe congenital neutropenia (SCN) and Clostridium septicum myonecrosis is an uncommon and life-threatening association requiring urgent combined aggressive medical and surgical management. We report 2 cases of SCN (1 with known Kostmann's syndrome and 1 not known at presentation to have a congenital neutropenic disorder but subsequently received a diagnosis of cyclic neutropenia) who presented with spontaneous C septicum myonecrosis. The cases highlight the importance of response to recombinant human granulocyte colony-stimulating factor in obtaining a satisfactory outcome for these patients. Early, empirical use of recombinant human granulocyte colony-stimulating factor in patients who are suspected of having a congenital neutropenia and who present with life-threatening sepsis is recommended.<\/jats:p>","DOI":"10.1542\/peds.2004-0124","type":"journal-article","created":{"date-parts":[[2004,12,11]],"date-time":"2004-12-11T22:27:41Z","timestamp":1102804061000},"page":"e757-e760","source":"Crossref","is-referenced-by-count":25,"title":["<i>Clostridium septicum<\/i> Myonecrosis in Congenital Neutropenia"],"prefix":"10.1542","volume":"114","author":[{"given":"Chris","family":"Barnes","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Ted","family":"Gerstle","sequence":"additional","affiliation":[{"name":"Division of Pediatric General Surgery, Department of Surgery, Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin H.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel D.","family":"Carcao","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"2021120819391269100_R1","doi-asserted-by":"crossref","unstructured":"Dale DC, Cottle TE, Fier CJ, et al. 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