{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:04:09Z","timestamp":1781478249887,"version":"3.54.1"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:p>Objective. To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood.<\/jats:p>\n               <jats:p>Design. Prospective follow-up study of a randomized, double-blind, placebo-controlled trial.<\/jats:p>\n               <jats:p>Setting. National Women's Hospital (Auckland, New Zealand).<\/jats:p>\n               <jats:p>Participants. Two hundred twenty-three 6-year-old children of mothers who presented with unplanned premature labor and took part in a randomized, controlled trial of prenatal betamethasone therapy for the prevention of neonatal RDS.<\/jats:p>\n               <jats:p>Intervention. Mothers received 2 doses of betamethasone (12 mg) or placebo, administered through intramuscular injection, 24 hours apart.<\/jats:p>\n               <jats:p>Main Outcome Measures. Systolic and diastolic blood pressure at 6 years of age.<\/jats:p>\n               <jats:p>Results. Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: \u22121.6 mm Hg; 95% confidence interval: \u22124.1 to 0.8 mm Hg; diastolic: \u22120.3 mm Hg; 95% confidence interval: \u22122.5 to 1.8 mm Hg).<\/jats:p>\n               <jats:p>Conclusion. Prenatal exposure to betamethasone for prevention of neonatal RDS does not alter blood pressure at 6 years of age.<\/jats:p>","DOI":"10.1542\/peds.2004-0196","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T17:23:17Z","timestamp":1099675397000},"page":"e373-e377","source":"Crossref","is-referenced-by-count":41,"title":["Blood Pressure at 6 Years of Age After Prenatal Exposure to Betamethasone: Follow-up Results of a Randomized, Controlled Trial"],"prefix":"10.1542","volume":"114","author":[{"given":"Stuart R.","family":"Dalziel","sequence":"first","affiliation":[{"name":"Clinical Trials Research Unit"},{"name":"Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Liang","sequence":"additional","affiliation":[{"name":"Starship Children's Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Parag","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Harding","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2004,9,1]]},"reference":[{"key":"2021121011131329700_R1","unstructured":"National Institutes of Health. Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consens Statement.\u20081994;12:1\u201324"},{"key":"2021121011131329700_R2","unstructured":"Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev.\u20082000;CD000065"},{"key":"2021121011131329700_R3","doi-asserted-by":"crossref","unstructured":"Benediktsson R, Lindsay RS, Noble J, Seckl JR, Edwards CR. Glucocorticoid exposure in utero: new model for adult hypertension. Lancet.\u20081993;341:339\u2013341","DOI":"10.1016\/0140-6736(93)90138-7"},{"key":"2021121011131329700_R4","doi-asserted-by":"crossref","unstructured":"Dodic M, May CN, Wintour EM, Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci.\u20081998;94:149\u2013155","DOI":"10.1042\/cs0940149"},{"key":"2021121011131329700_R5","doi-asserted-by":"crossref","unstructured":"Moise AA, Wearden ME, Kozinetz CA, Gest AL, Welty SE, Hansen TN. Antenatal steroids are associated with less need for blood pressure support in extremely premature infants. Pediatrics.\u20081995;95:845\u2013850","DOI":"10.1542\/peds.95.6.845"},{"key":"2021121011131329700_R6","doi-asserted-by":"crossref","unstructured":"Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci.\u20082000;98:137\u2013142","DOI":"10.1042\/cs0980137"},{"key":"2021121011131329700_R7","doi-asserted-by":"crossref","unstructured":"Dessens AB, Haas HS, Koppe JG. Twenty-year follow-up of antenatal corticosteroid treatment. Pediatrics.\u20082000;105(6). Available at: www.pediatrics.org\/cgi\/content\/full\/105\/6\/e77","DOI":"10.1542\/peds.105.6.e77"},{"key":"2021121011131329700_R8","doi-asserted-by":"crossref","unstructured":"Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. 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School progress and cognitive development of 6-year-old children whose mothers were treated antenatally with betamethasone. Pediatrics.\u20081982;70:99\u2013105","DOI":"10.1542\/peds.70.1.99"},{"key":"2021121011131329700_R12","unstructured":"SAS Institute Inc. The SAS System for Windows. Cary, NC: SAS Institute Inc; 1999"},{"key":"2021121011131329700_R13","unstructured":"Altuman DG, Machin D, Bryant TN, Gardner MJ. Statistics with Confidence. London, United Kingdom: BMJ Books; 2000"},{"key":"2021121011131329700_R14","doi-asserted-by":"crossref","unstructured":"Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health.\u20081989;79:340\u2013349","DOI":"10.2105\/AJPH.79.3.340"},{"key":"2021121011131329700_R15","unstructured":"Thompson JM, Mitchell EA, Borman B. Sex specific birthweight percentiles by gestational age for New Zealand. N Z Med J.\u20081994;107:1\u20133"},{"key":"2021121011131329700_R16","doi-asserted-by":"crossref","unstructured":"Seckl JR, Cleasby M, Nyirenda MJ. Glucocorticoids, 11\u03b2-hydroxysteroid dehydrogenase, and fetal programming. Kidney Int.\u20082000;57:1412\u20131417","DOI":"10.1046\/j.1523-1755.2000.00984.x"},{"key":"2021121011131329700_R17","doi-asserted-by":"crossref","unstructured":"Erickson K, Schmidt L, Santesso DL, Schulkin J, Gregory K, Hobel C. Obstetrician-gynecologists' knowledge and training about antenatal corticosteroids. 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