{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:04:39Z","timestamp":1773288279750,"version":"3.50.1"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:p>Objective. Acute asphyxial asthma (AAA) is well described in adult patients and is characterized by a sudden onset that may rapidly progress to a near-arrest state. Despite the initial severity of AAA, mechanical ventilation often restores gas exchange promptly, resulting in shorter durations of ventilation. We believe that AAA can occur in children and can lead to respiratory failure that requires mechanical ventilation. Furthermore, children with rapid-onset respiratory failure that requires intubation in the emergency department (ED) are more likely to have AAA and a shorter duration of mechanical ventilation than those intubated in the pediatric intensive care unit (PICU).<\/jats:p><jats:p>Methods. An 11-year retrospective chart review (1991-2002) was conducted of all children who were aged 2 through 18 years and had the primary diagnosis of status asthmaticus and required mechanical ventilation.<\/jats:p><jats:p>Results. During the study period, 33 (11.4%) of 290 PICU admissions for status asthmaticus required mechanical ventilation. Thirteen children presented with rapid respiratory failure en route, on arrival, or within 30 minutes of arrival to the ED versus 20 children who progressed to respiratory failure later in their ED course or in the PICU. Mean duration of mechanical ventilation was significantly shorter in the children who presented with rapid respiratory failure versus those with progressive respiratory failure (29 \u00b1 43 hours vs 88 \u00b1 72 hours). Children with rapid respiratory failure had greater improvements in ventilation and oxygenation than those with progressive respiratory failure as measured by pre- and postintubation changes in arterial carbon dioxide pressure, arterial oxygen pressure\/fraction of inspired oxygen ratio, and alveolar-arterial gradient. According to site of intubation, 23 children required intubation in the ED, whereas 10 were intubated later in the PICU. Mean duration of mechanical ventilation was significantly shorter in the ED group versus the PICU group (42 \u00b1 63 hours vs 118 \u00b1 46 hours). There were significantly greater improvements in ventilation and oxygenation in the ED group versus the PICU group as measured by pre- and postintubation changes in arterial carbon dioxide pressure and arterial oxygen pressure\/fraction of inspired oxygen ratio.<\/jats:p><jats:p>Conclusions. AAA occurs in children and shares characteristics seen in adult counterparts. Need for early intubation is a marker for AAA and may not represent a failure to maximize preintubation therapies. AAA represents a distinct form of life-threatening asthma and requires additional study in children.<\/jats:p>","DOI":"10.1542\/peds.2004-0294","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T17:23:17Z","timestamp":1099675397000},"page":"762-767","source":"Crossref","is-referenced-by-count":29,"title":["Duration of Mechanical Ventilation in Life-Threatening Pediatric Asthma: Description of an Acute Asphyxial Subgroup"],"prefix":"10.1542","volume":"114","author":[{"given":"Frank A.","family":"Maffei","sequence":"first","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise W.","family":"van der Jagt","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.","family":"Powers","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Standage","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi V.","family":"Connolly","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Harmon","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Rubenstein","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Critical Care, Strong Children's Research Center of the University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2004,9,1]]},"reference":[{"key":"2021121011125874100_R1","unstructured":"Mannino DM, Homa DM, Akinbami LJ, et al. 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