{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:56:27Z","timestamp":1793642187469,"version":"4.5.1"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,1]]},"abstract":"<jats:p>We reviewed 12 patients who had Kikuchi-Fujimoto disease (KFD) and presented with prolonged fever and lymphadenopathy. The clinical and laboratory aspects of the patients confirmed by excisional lymph node biopsy were analyzed. The mean age of the children was 11.0 \u00b1 3.0 years (range: 6\u201315 years). The male-to-female ratio was 1.4:1. The median duration of fever before admission and the total duration of fever was 13 days (range: 7\u201365 days) and 19.5 days (range: 9\u201375 days), respectively. One patient had supraclavicular lymphadenopathy, 10 had cervical involvement, and 1 had axillary lymphadenopathy. All of the histologic findings of the lymph node biopsies showed the characteristic findings consistent with KFD, such as paracortical necrosis with karyorrhexis and an increase in the number of phagocytic histiocytes and atypical lymphocytes. As for the laboratory findings, leukopenia (3600 \u00b1 900 per mm3), anemia (hemoglobin 11.4 \u00b1 1.2 g\/dL), an elevated erythrocyte sedimentation rate (44 \u00b1 18 mm\/hour), and a relatively low C-reactive protein level (1.3 \u00b1 1.1 mg\/dL) were noted. Eight patients received conservative therapy with antipyretics, and 3 patients were treated with prednisolone. KFD is a rare disease yet should be considered in the differential diagnosis for older children with prolonged fever and lymphadenopathy.<\/jats:p>","DOI":"10.1542\/peds.2004-0485","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T20:25:36Z","timestamp":1100550336000},"page":"e752-e756","source":"Crossref","is-referenced-by-count":65,"title":["Kikuchi-Fujimoto Disease With Prolonged Fever in Children"],"prefix":"10.1542","volume":"114","author":[{"given":"Kyung-Yil","family":"Lee","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Catholic University of Korea, College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Heum","family":"Yeon","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Catholic University of Korea, College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Churl","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Catholic University of Korea, College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"2021120819421445800_R1","unstructured":"Kikuchi M. 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