{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:11:44Z","timestamp":1770502304156,"version":"3.49.0"},"reference-count":45,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:p>Objective. To determine whether cholecystokinin-octapeptide (CCK-OP) would prevent or ameliorate parenteral nutrition-associated cholestasis (PNAC) among high-risk neonates treated with total parenteral nutrition.<\/jats:p><jats:p>Study Design. This was a multicenter, double-blind, randomized, controlled trial conducted between 1996 and 2001.<\/jats:p><jats:p>Patients. Neonates at risk for the development of PNAC included very low birth weight neonates and those with major surgical conditions involving the gastrointestinal tract.<\/jats:p><jats:p>Setting. Tertiary care hospitals.<\/jats:p><jats:p>Intervention. Patients were randomized to receive CCK-OP (0.04 \u03bcg\/kg per dose, twice daily) or placebo. Eligible infants were all &amp;lt;30 days of age. Patients were enrolled within 2 weeks after birth or within 7 days after surgery.<\/jats:p><jats:p>Outcome Measures. The primary outcome measure was conjugated bilirubin (CB) levels, which were measured weekly. Secondary outcome measures included incidence of sepsis, times to achieve 50% and 100% of energy intake through the enteral route, number of ICU and hospital days, mortality rate, and incidences of biliary sludge and cholelithiasis.<\/jats:p><jats:p>Results. A total of 243 neonates were enrolled in the study. CCK-OP administration did not significantly affect CB levels (1.76 \u00b1 3.14 and 1.93 \u00b1 3.31 mg\/dL for CCK-OP and placebo groups, respectively; mean \u00b1 SD). Secondary outcome measures also were not significantly affected by the study drug.<\/jats:p><jats:p>Conclusions. Use of CCK-OP failed to reduce significantly the incidence of PNAC or levels of CB. CCK-OP had no effect on other secondary measures and should not be recommended for the prevention of PNAC.<\/jats:p>","DOI":"10.1542\/peds.2004-1014","type":"journal-article","created":{"date-parts":[[2005,5,2]],"date-time":"2005-05-02T19:38:07Z","timestamp":1115062687000},"page":"1332-1340","source":"Crossref","is-referenced-by-count":57,"title":["Use of Cholecystokinin-Octapeptide for the Prevention of Parenteral Nutrition-Associated Cholestasis"],"prefix":"10.1542","volume":"115","author":[{"given":"Daniel H.","family":"Teitelbaum","sequence":"first","affiliation":[{"name":"Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Thomas F.","family":"Tracy","sequence":"additional","affiliation":[{"name":"Hasbro Children's Hospital, Brown Medical School, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustafa M.","family":"Aouthmany","sequence":"additional","affiliation":[{"name":"St Vincent's Mercy Children's Hospital, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Llanos","sequence":"additional","affiliation":[{"name":"Strong Memorial Hospital, University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morton B.","family":"Brown","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunkyung","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Strong Memorial Hospital, University of Rochester, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B.","family":"Hirschl","sequence":"additional","affiliation":[{"name":"Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Derusso","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Cox","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Dahlgren","sequence":"additional","affiliation":[{"name":"Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan I.","family":"Groner","sequence":"additional","affiliation":[{"name":"Columbus Children's Hospital, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Strouse","sequence":"additional","affiliation":[{"name":"Department of Radiology, C.S. 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