{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:45:59Z","timestamp":1774125959900,"version":"3.50.1"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:p>Objectives. To determine risk factors that are associated with the presence of latent tuberculosis infection (LTBI) in Mexican American children.<\/jats:p><jats:p>Methods. In this prospective cohort study, we administered tuberculin skin tests (TSTs) and a tuberculosis (TB) risk factor questionnaire to children who were aged 1 to 18 years in immigrant families at a Denver inner-city community health center and elementary school\u2013based health center. Information requested on the questionnaire included child demographics, child and parent birth location, Bacille Calmette-Gue\u0301rin (BCG) vaccination, and a history and the duration of child and family travel to and visitors from countries where TB is endemic. TST results were read at 48 to 72 hours and were interpreted as positive at 5- and 10-mm induration, depending on risk factor history. All participants received $5 coupons on return for TST reading.<\/jats:p><jats:p>Results. Of 584 children enrolled, 96% returned for TST evaluation, median age was 4 years, 48.6% were male, 98.5% were Latino, 66.3% were born in the United States, and 33% were born in Mexico. Overall, 12.4% of children had positive TSTs. For all children in the study, a positive TST was associated with birth in Mexico and no BCG received (adjusted odds ratio [OR]: 15.7; 95% confidence interval [CI]: 1.5\u2013165.2), birth in Mexico and received BCG (adjusted OR: 29; 95% CI: 12.7\u201366.1), birth in the United States and received BCG (adjusted OR: 9.1; 95% CI: 2.4\u201334.1), and child travel to Mexico (adjusted OR: 2.8;95% CI: 1.5\u20135.4). Risk factors for having a positive TST in the 387 children who were born in the United States were travel to Mexico (unable to calculate the OR because all had traveled to Mexico), older age (median: 6 years; adjusted OR: 1.2\/year; 95% CI: 1.02\u20131.40), and a history of BCG vaccination (adjusted OR: 8.2; 95% CI: 2.0\u201334.0). For the 195 children who were born in Mexico, logistic regression of the following variables showed that none of the variables remained in the model: child age, gender, BCG status, family travel to Mexico, visitors to the United States, child travel to Mexico, years lived in Mexico, and years since BCG.<\/jats:p><jats:p>Conclusions. In a population of primarily Mexican American children, those who were born in the United States had an increased risk for developing LTBI when they had a history of BCG vaccination or had traveled to Mexico. For children who were born in Mexico, we were unable to identify additional risk factors for the presence of LTBI, besides their birth in Mexico. Incentives for return for TST reading, such as grocery coupons, are highly effective.<\/jats:p>","DOI":"10.1542\/peds.2004-1685","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T17:19:46Z","timestamp":1117646386000},"page":"e647-e653","source":"Crossref","is-referenced-by-count":18,"title":["Risk Factors Associated With Latent Tuberculosis Infection in Mexican American Children"],"prefix":"10.1542","volume":"115","author":[{"given":"Janine","family":"Young","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Denver Health, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Denver Health, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"2021120819231070400_R1","unstructured":"Centers for Disease Control and Prevention. Trends in tuberculosis morbidity\u2014United States, 1992\u20132002. MMWR Morb Mortal Wkly Rep.\u20082003;52:218\u2013224"},{"key":"2021120819231070400_R2","unstructured":"Centers for Disease Control and Prevention. Trends in tuberculosis\u2014United States, 1998\u20132003. MMWR Morb Mortal Wkly Rep.\u20082004;53:209\u2013214"},{"key":"2021120819231070400_R3","unstructured":"American Academy of Pediatrics. Tuberculosis. In: Pickering LK, ed. Red Book: 2003 Report of the Committee on Infectious Diseases. 26th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2003:642\u2013660"},{"key":"2021120819231070400_R4","doi-asserted-by":"crossref","unstructured":"Horsburgh CR. Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med.\u20082004;350:2060\u20132067","DOI":"10.1056\/NEJMsa031667"},{"key":"2021120819231070400_R5","doi-asserted-by":"crossref","unstructured":"Lifson AR, Halcon LL, Johnston AM, et al. Tuberculin skin testing among economically disadvantaged youth in a federally funded job training program. Am J Epidemiol.\u20081998;149:671\u2013679","DOI":"10.1093\/oxfordjournals.aje.a009868"},{"key":"2021120819231070400_R6","doi-asserted-by":"crossref","unstructured":"Sun SJ, Bennett DE, Flood J, Loeffler AM, Kammerer S, Ellis B. Identifying the sources of tuberculosis in young children: a multistate investigation. Emerg Infect Dis.\u20082002;8:1216\u20131223","DOI":"10.3201\/eid0811.020419"},{"key":"2021120819231070400_R7","doi-asserted-by":"crossref","unstructured":"McKenna MT, McCray E, Onorato I. The epidemiology of tuberculosis among foreign-born persons in the United States, 1986\u20131993. N Engl J Med.\u20081995;332:1071\u20131076","DOI":"10.1056\/NEJM199504203321606"},{"key":"2021120819231070400_R8","doi-asserted-by":"crossref","unstructured":"Talbot EA, Moore M, McCray E, Binkin NJ. Tuberculosis among foreign-born persons in the United States, 1993\u20131998. JAMA.\u20082000;284:2894\u20132900","DOI":"10.1001\/jama.284.22.2894"},{"key":"2021120819231070400_R9","doi-asserted-by":"crossref","unstructured":"Barnes PF, Cave MD. Molecular epidemiology of tuberculosis. N Engl J Med.\u20082003;349:1149\u20131156","DOI":"10.1056\/NEJMra021964"},{"key":"2021120819231070400_R10","doi-asserted-by":"crossref","unstructured":"Chin DP, DeRiemer K, Small PM, et al. Differences in contributing factors to tuberculosis incidence in US-born and foreign-born persons. Am J Respir Crit Care Med.\u20081998;158:1797\u20131803","DOI":"10.1164\/ajrccm.158.6.9804029"},{"key":"2021120819231070400_R11","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, Committee on Infectious Disease. Update on tuberculin skin testing of children. Pediatrics.\u20081996;97:281\u2013284","DOI":"10.1542\/peds.97.2.282"},{"key":"2021120819231070400_R12","unstructured":"Cheng TL, Ottolini MC, Miller EB, Rosenquist G. Tuberculosis testing: physician attitudes and practice [abstract]. Arch Pediatr Adolesc Med.\u20081995;149:71"},{"key":"2021120819231070400_R13","doi-asserted-by":"crossref","unstructured":"Gounder CR, Driver CR, Scholten JN, Shen H, Munsiff SS. Tuberculin testing and risk of tuberculosis infection among New York City schoolchildren. Pediatrics.\u20082003;111 (4). Available at: www.pediatrics.org\/cgi\/content\/full\/111\/4\/e316","DOI":"10.1542\/peds.111.4.e309"},{"key":"2021120819231070400_R14","doi-asserted-by":"crossref","unstructured":"Hsu K, Christiansen D, O'Connor D, Bernardo J, Hacker K. Self-assessment of tuberculosis infection risk by urban adolescents. Arch Pediatr Adolesc Med.\u20082003;157:1227\u20131231","DOI":"10.1001\/archpedi.157.12.1227"},{"key":"2021120819231070400_R15","doi-asserted-by":"crossref","unstructured":"Froehlich H, Ackerson LM, Morozumi PA, et al. Targeted testing of children for tuberculosis: validation of a risk assessment questionnaire. Pediatrics.\u20082001;107(4). Available at: www.pediatrics.org\/cgi\/content\/full\/107\/4\/e54","DOI":"10.1542\/peds.107.4.e54"},{"key":"2021120819231070400_R16","doi-asserted-by":"crossref","unstructured":"Saiman L, San Gabriel P, Schulte J, Pementel Vargas M, Kenyon T, Onorato I. Risk factors for latent tuberculosis infection among children in New York City. Pediatrics.\u20082001;107:999\u20131003","DOI":"10.1542\/peds.107.5.999"},{"key":"2021120819231070400_R17","doi-asserted-by":"crossref","unstructured":"Ozuah PO, Ozuah TP, Stein REK, Burton W, Mulvihill M. Evaluation of a risk assessment questionnaire used to target tuberculin skin testing in children. JAMA.\u20082001;285:451\u2013453","DOI":"10.1001\/jama.285.4.451"},{"key":"2021120819231070400_R18","doi-asserted-by":"crossref","unstructured":"Lobato MN, Hopewell PC. Mycobacterium tuberculosis infection after travel to or contact with visitors from countries with a high prevalence of tuberculosis. Am J Respir Crit Care Med.\u20081998;158:1871\u20131875","DOI":"10.1164\/ajrccm.158.6.9804106"},{"key":"2021120819231070400_R19","unstructured":"World Health Organization. Global tuberculosis control: surveillance, planning, financing\u20142002. Available at: www.who.int\/docstore\/gtb\/publications\/globerep02\/PDF\/pages145to182.pdf. Accessed March 23, 2005"},{"key":"2021120819231070400_R20","doi-asserted-by":"crossref","unstructured":"Entzel PP, Fleming LE, Trepka MJ, Squicciarini D. The health status of newly arrived refugee children in Miami-Dade County, Florida. Am J Public Health.\u20082003;93:286\u2013288","DOI":"10.2105\/AJPH.93.2.286"},{"key":"2021120819231070400_R21","unstructured":"US Census Bureau. Colorado QuickFacts. 2000. Available at: http:\/\/quickfacts.census.gov\/qfd\/states\/08\/08031.html. Accessed July 27, 2004"},{"key":"2021120819231070400_R22","unstructured":"Centers for Disease Control and Prevention. 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