{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:59:58Z","timestamp":1768017598671,"version":"3.49.0"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:p>Although inflammatory bowel disease (IBD) typically presents with gastrointestinal complaints, mucocutaneous lesions are commonly associated and can precede gastrointestinal symptoms, thereby alerting the clinician to the diagnosis of IBD before the onset of gastrointestinal symptoms. Nine children are reported who had no gastrointestinal symptoms suggestive of IBD but presented with mucocutaneous findings of IBD and were subsequently diagnosed with Crohn's disease or ulcerative colitis based on characteristic features on gastrointestinal endoscopy and\/or biopsies. The majority of the patients had oral and perianal lesions. We believe that IBD is a common etiology for persistent oral lesions in the pediatric population. In addition to a good history, children with unexplained oral mucous membrane lesions should have an examination of the rectal and genital mucosa as well as tests for complete blood count, iron levels, sedimentation rate, albumin, and occult blood in the stool with endoscopy and biopsies to rule out IBD if indicated.<\/jats:p>","DOI":"10.1542\/peds.2004-2281","type":"journal-article","created":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T01:48:13Z","timestamp":1123811293000},"page":"e439-e444","source":"Crossref","is-referenced-by-count":54,"title":["Asymptomatic Inflammatory Bowel Disease Presenting With Mucocutaneous Findings"],"prefix":"10.1542","volume":"116","author":[{"given":"Sheila S.","family":"Galbraith","sequence":"first","affiliation":[{"name":"Department of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Drolet","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subra","family":"Kugathasan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy B.","family":"Esterly","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"2021120820040720200_R1","doi-asserted-by":"crossref","unstructured":"Ploysangam T, Heubi JE, Eisen D, Balistreri WF, Lucky AW. Cutaneous Crohn's disease in children. J Am Acad Dermatol.\u20081997:36:697\u2013704","DOI":"10.1016\/S0190-9622(97)80320-9"},{"key":"2021120820040720200_R2","doi-asserted-by":"crossref","unstructured":"McCallum DI, Kinmont PD. Dermatological manifestations of Crohn's disease. Br J Dermatol.\u20081968;80:1\u20138","DOI":"10.1111\/j.1365-2133.1968.tb11898.x"},{"key":"2021120820040720200_R3","doi-asserted-by":"crossref","unstructured":"Greenstein AJ, Janowitz HD, Sachar DB. The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients. Medicine (Baltimore).\u20081976;55:401\u2013412","DOI":"10.1097\/00005792-197609000-00004"},{"key":"2021120820040720200_R4","doi-asserted-by":"crossref","unstructured":"Plauth M, Jenss H, Meyle J. Oral manifestations of Crohn's disease. An analysis of 79 cases. J Clin Gastroenterol.\u20081991;13:29\u201337","DOI":"10.1097\/00004836-199102000-00008"},{"key":"2021120820040720200_R5","doi-asserted-by":"crossref","unstructured":"Gregory B, Ho VC. Cutaneous manifestations of gastrointestinal disorders. Part II. J Am Acad Dermatol.\u20081992:26(3 pt 2):371\u2013383","DOI":"10.1016\/0190-9622(92)70059-O"},{"key":"2021120820040720200_R6","doi-asserted-by":"crossref","unstructured":"Burgdorf WH. Cutaneous manifestations of Crohn's disease. J Am Acad Dermatol.\u20081981;5:689\u2013695","DOI":"10.1016\/S0190-9622(81)70130-0"},{"key":"2021120820040720200_R7","unstructured":"Apgar JT. Newer aspects of inflammatory bowel disease and its cutaneous manifestations: a selective review. Semin Dermatol.\u20081991;10:138\u2013147"},{"key":"2021120820040720200_R8","doi-asserted-by":"crossref","unstructured":"Powell FC, Perry HO. Pyoderma gangrenosum in childhood. Arch Dermatol.\u20081984;120:757\u2013761","DOI":"10.1001\/archderm.120.6.757"},{"key":"2021120820040720200_R9","doi-asserted-by":"crossref","unstructured":"Paller AS, Sahn EE, Garen PD, Dobson RL, Chadwick EG. Pyoderma gangrenosum in pediatric acquired immunodeficiency syndrome. J Pediatr.\u20081990:117:63\u201366","DOI":"10.1016\/S0022-3476(05)82444-8"},{"key":"2021120820040720200_R10","doi-asserted-by":"crossref","unstructured":"Gilman AL, Cohen BA, Urback AH, Blatt J. Pyoderma gangrenosum as a manifestation of leukemia in childhood. Pediatrics.\u20081988;81:846\u2013848","DOI":"10.1542\/peds.81.6.846"},{"key":"2021120820040720200_R11","unstructured":"Mir-Madjlessi SH, Taylor JS, Farmer RG. Clinical course and evolution of erythema nodosum and pyoderma gangrenosum in chronic ulcerative colitis: a study of 42 patients. Am J Gastroenterol.\u20081985;80:615\u2013620"},{"key":"2021120820040720200_R12","unstructured":"Baker WN, Milton-Thompson GJ. The anal lesion as the sole presenting symptom of intestinal Crohn's disease. Gut.\u20081971;12:865"},{"key":"2021120820040720200_R13","doi-asserted-by":"crossref","unstructured":"Lebwohl M, Lebwohl O. Cutaneous manifestations of inflammatory bowel disease. Inflamm Bowel Dis.\u20081998;4:142\u2013148","DOI":"10.1097\/00054725-199805000-00025"},{"key":"2021120820040720200_R14","doi-asserted-by":"crossref","unstructured":"Basu MK, Asquith P. Oral manifestations of inflammatory bowel disease. Clin Gastroenterol.\u20081980;9:307\u2013321","DOI":"10.1016\/S0300-5089(21)00451-X"},{"key":"2021120820040720200_R15","doi-asserted-by":"crossref","unstructured":"Berstein ML, McDonald JS. Oral lesions in Crohn's disease: report of two cases and update of the literature. Oral Surg Oral Med Oral Pathol.\u20081978;46:234\u2013245","DOI":"10.1016\/0030-4220(78)90198-6"},{"key":"2021120820040720200_R16","unstructured":"Wiesenfeld D, Ferguson MM, Mitchell DN, et al. Oro-facial granulomatosis\u2014a clinical and pathological analysis. Q J Med.\u20081985;54:101\u2013113"},{"key":"2021120820040720200_R17","unstructured":"Williams AJ, Wray D, Ferguson A. The clinical entity of orofacial Crohn's disease. Q J Med.\u20081991;79:451\u2013458"},{"key":"2021120820040720200_R18","unstructured":"Barnard KM, Walker-Smith JA. The prevalence of oral manifestations of inflammatory bowel disease in a paediatric population [abstract]. J Dent Res.\u20081994;73:A388"},{"key":"2021120820040720200_R19","doi-asserted-by":"crossref","unstructured":"Pittock S, Drumm B, Fleming P, et al. The oral cavity in Crohn's disease. J Pediatr.\u20082001;138:767\u2013771","DOI":"10.1067\/mpd.2001.113008"},{"key":"2021120820040720200_R20","doi-asserted-by":"crossref","unstructured":"Scully C, Cochran KM, Russell RI, et al. Crohn's disease of the mouth: an indicator of intestinal involvement. Gut.\u20081982;23:198\u2013201","DOI":"10.1136\/gut.23.3.198"},{"key":"2021120820040720200_R21","doi-asserted-by":"crossref","unstructured":"Bogenrieder T, Rogler G, Vogt T, Landthaler M, Stolz W. Orofacial granulomatosis as the initial presentation of Crohn's disease in an adolescent. Dermatology.\u20082003;206:273\u2013278","DOI":"10.1159\/000068900"},{"key":"2021120820040720200_R22","doi-asserted-by":"crossref","unstructured":"van de Scheur MR, van der Waal RI, van der Waal I, Stoof TJ, van Deventer SJ. Ano-genital granulomatosis: the counterpart of oro-facial granulomatosis. J Eur Acad Dermatol Venereol.\u20082003;17:184\u2013189","DOI":"10.1046\/j.1468-3083.2003.00573.x"},{"key":"2021120820040720200_R23","doi-asserted-by":"crossref","unstructured":"Poon KS, Gilks CB, Masterson JS. Metastatic Crohn's disease involving the genitalia. J Urol.\u20082002;167:2541\u20132542","DOI":"10.1016\/S0022-5347(05)65032-X"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/116\/3\/e439\/1005150\/zpe0090500e439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/116\/3\/e439\/1005150\/zpe0090500e439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T04:12:49Z","timestamp":1683173569000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/116\/3\/e439\/68412\/Asymptomatic-Inflammatory-Bowel-Disease-Presenting"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,1]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,9,1]]},"published-print":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2004-2281","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,1]]}}}