{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:49:50Z","timestamp":1775166590216,"version":"3.50.1"},"reference-count":10,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:p>A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck revealed a thrombus in the internal jugular vein. A presumptive diagnosis of Lemierre's syndrome was made and he was started on antibiotics and anticoagulation. He subsequently developed adult respiratory distress syndrome and required high frequency oscillatory ventilation for 9 days. Blood cultures were positive for Fusobacterium necrophorum. Screening for hypercoagulability revealed 2 known risk factors: a mutation in the prothrombin gene and elevated lipoprotein a.<\/jats:p>","DOI":"10.1542\/peds.2004-2505","type":"journal-article","created":{"date-parts":[[2005,4,16]],"date-time":"2005-04-16T00:25:41Z","timestamp":1113611141000},"page":"e620-e622","source":"Crossref","is-referenced-by-count":37,"title":["Respiratory Failure and Hypercoagulability in a Toddler With Lemierre's Syndrome"],"prefix":"10.1542","volume":"115","author":[{"given":"Tal","family":"Schmid","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Miskin","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yechiel","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Unit, Shaare Zedek Medical Center, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Argaman","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kleid","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"2021120819290757800_R1","doi-asserted-by":"crossref","unstructured":"Lemierre A. 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Available at: www.pediatrics.org\/cgi\/content\/full\/112\/5\/e380","DOI":"10.1542\/peds.112.5.e380"},{"key":"2021120819290757800_R5","doi-asserted-by":"crossref","unstructured":"Briggs S, Pappachan J, Argent J, et al. Lemierre syndrome in the pediatric intensive care unit, clinical course and the use of high-frequency oscillatory ventilation. Pediatr Crit Care Med.\u20082003;4:107\u2013110","DOI":"10.1097\/00130478-200301000-00022"},{"key":"2021120819290757800_R6","unstructured":"Alvarez A, Schreiber JR. Lemierre's syndrome in adolescent children\u2014anaerobic sepsis with internal jugular vein thrombophlebitis following pharyngitis. Pediatrics.\u20081995;96:354\u2013359"},{"key":"2021120819290757800_R7","doi-asserted-by":"crossref","unstructured":"Hoehn S, Dominguez TE. Lemierre's syndrome: an unusual cause of sepsis and abdominal pain. 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Laryngoscope.\u20082004;114:90\u201395","DOI":"10.1097\/00005537-200401000-00015"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/115\/5\/e620\/1028525\/zpe0050500e620.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/115\/5\/e620\/1028525\/zpe0050500e620.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T20:29:36Z","timestamp":1638995376000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/115\/5\/e620\/67610\/Respiratory-Failure-and-Hypercoagulability-in-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,1]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2005,5,1]]},"published-print":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2004-2505","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,1]]}}}