{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:31:12Z","timestamp":1790883072227,"version":"4.1.0"},"reference-count":46,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,1]]},"abstract":"<jats:p>Objective. Children with sickle cell disease (SCD) experience poor growth, altered body composition, and delayed maturation. Deficits in bone mineral content (BMC) and bone area (BA) have not been well characterized. The objectives of this study were to assess whole-body BMC (WBBMC) and WBBA in children with SCD, type SS (SCD-SS), compared with healthy control subjects, adjusted for growth and body composition, and to determine the relationships of WBBMC and WBBA to bone age and hematologic parameters in children with SCD-SS.<\/jats:p><jats:p>Methods. WBBMC, WBBA, and lean mass were measured by dual-energy x-ray absorptiometry in children who were aged 4 to 19 years. Growth, sexual development, and bone age were assessed. Gender-specific z scores for WBBMC relative to age and height were generated from control data.<\/jats:p><jats:p>Results. Ninety children with SCD-SS and 198 healthy control subjects were evaluated. SCD-SS was associated with poor growth. WBBMC was significantly decreased in SCD-SS compared with control subjects, adjusted for age, height, pubertal status, and lean mass. WBBMC relative to age and WBBMC relative to height z scores were \u22120.95 \u00b1 0.99 and \u22120.54 \u00b1 0.97, respectively, and were associated with hemoglobin and hematocrit levels and history of delayed bone age.<\/jats:p><jats:p>Conclusions. Children with SCD-SS have significant deficits in WBBMC that persist despite adjustment for poor growth and decreased lean mass. These children may be at increased risk for fragility fractures and suboptimal peak bone mass.<\/jats:p>","DOI":"10.1542\/peds.2004-2582","type":"journal-article","created":{"date-parts":[[2005,9,30]],"date-time":"2005-09-30T18:42:55Z","timestamp":1128105775000},"page":"943-949","source":"Crossref","is-referenced-by-count":59,"title":["Bone Area and Bone Mineral Content Deficits in Children With Sickle Cell Disease"],"prefix":"10.1542","volume":"116","author":[{"given":"Anne M.","family":"Buison","sequence":"first","affiliation":[{"name":"Gastroenterology and Nutrition"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Kawchak","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan I.","family":"Schall","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku","family":"Ohene-Frempong","sequence":"additional","affiliation":[{"name":"Divisions of Hematology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"Stallings","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Divisions of Nephrology, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette S.","family":"Zemel","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2021120819491060700_R1","doi-asserted-by":"crossref","unstructured":"Platt OS, Rosenstock W, Espeland MA. 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West Indian Med J.\u20081995;44:20\u201323"},{"key":"2021120819491060700_R5","doi-asserted-by":"crossref","unstructured":"Barden EM, Zemel BS, Kawchak DA, Goran MI, Ohene-Frempong K, Stallings VA. Total and resting energy expenditure in children with sickle cell disease. J Pediatr.\u20082000;136:73\u201379","DOI":"10.1016\/S0022-3476(00)90053-2"},{"key":"2021120819491060700_R6","doi-asserted-by":"crossref","unstructured":"Borel MJ, Buchowski MS, Turner EA, Goldstein RE, Flakoll PJ. Protein turnover and energy expenditure increase during exogenous nutrient availability in sickle cell disease. Am J Clin Nutr.\u20081998;68:607\u2013614","DOI":"10.1093\/ajcn\/68.3.607"},{"key":"2021120819491060700_R7","doi-asserted-by":"crossref","unstructured":"Malinauskas BM, Gropper SS, Kawchak DA, Zemel BS, Ohene-Frempong K, Stallings VA. Impact of acute illness on nutritional status of infants and young children with sickle cell disease. J Am Diet Assoc.\u20082000;100:330\u2013334","DOI":"10.1016\/S0002-8223(00)00103-6"},{"key":"2021120819491060700_R8","doi-asserted-by":"crossref","unstructured":"Soliman AT, Bererhi H, Darwish A, Alzalabani MM, Wali Y, Ansari B. Decreased bone mineral density in prepubertal children with sickle cell disease: correlation with growth parameters, degree of siderosis and secretion of growth factors. J Trop Pediatr.\u20081998;44:194\u2013198","DOI":"10.1093\/tropej\/44.4.194"},{"key":"2021120819491060700_R9","unstructured":"Brinker MR, Thomas KA, Meyers SJ, et al. Bone mineral density of the lumbar spine and proximal femur is decreased in children with sickle cell anemia. Am J Orthop.\u20081998;27:43\u201349"},{"key":"2021120819491060700_R10","unstructured":"Group WS. Assessment of Fracture Risk and Its Application to Screening for Postmenopausal Osteoporosis. Geneva, Switzerland: World Health Organization; 1994. Report 843"},{"key":"2021120819491060700_R11","doi-asserted-by":"crossref","unstructured":"Heaney RP. Bone mineral content, not bone mineral density, is the correct bone measure for growth studies. Am J Clin Nutr.\u20082003;78:350\u2013351; author reply 351\u2013352","DOI":"10.1093\/ajcn\/78.2.350"},{"key":"2021120819491060700_R12","doi-asserted-by":"crossref","unstructured":"Nevill AM, Holder RL, Maffulli N, et al. Adjusting bone mass for differences in projected bone area and other confounding variables: an allometric perspective. J Bone Miner Res.\u20082002;17:703\u2013708","DOI":"10.1359\/jbmr.2002.17.4.703"},{"key":"2021120819491060700_R13","doi-asserted-by":"crossref","unstructured":"Leonard MB, Shults J, Elliott DM, Stallings VA, Zemel BS. Interpretation of whole body dual energy X-ray absorptiometry measures in children: comparison with peripheral quantitative computed tomography. 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