{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:31:45Z","timestamp":1789803105390,"version":"4.0.1"},"reference-count":42,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:p>Objectives. To assess the incidence and complications of breastfeeding-associated hypernatremic dehydration among hospitalized neonates.<\/jats:p><jats:p>Study Design. A retrospective study was conducted at Children's Hospital of Pittsburgh over a 5-year period, to identify otherwise healthy term and near-term (\u226535 weeks of gestation) breastfed neonates (&amp;lt;29 days of age) who were admitted with serum sodium concentrations of \u2265150 mEq\/L and no explanation for hypernatremia other than inadequate milk intake.<\/jats:p><jats:p>Results. The incidence of breastfeeding-associated hypernatremic dehydration among 3718 consecutive term and near-term hospitalized neonates was 1.9%, occurring for 70 infants. These infants were born primarily to primiparous women (87%) who were discharged within 48 hours after birth (90%). The most common presenting symptom was jaundice (81%). Sixty-three percent of infants underwent sepsis evaluations with lumbar puncture. No infants had bacteremia or meningitis. Infants had hypernatremia of moderate severity (median: 153 mEq\/L; range: 150\u2013177 mEq\/L), with a mean weight loss of 13.7%. Nonmetabolic complications occurred for 17% of infants, with the most common being apnea and\/or bradycardia. There were no deaths.<\/jats:p><jats:p>Conclusion. Hypernatremic dehydration requiring hospitalization is common among breastfed neonates. Increased efforts are required to establish successful breastfeeding.<\/jats:p>","DOI":"10.1542\/peds.2004-2647","type":"journal-article","created":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:36:02Z","timestamp":1125534962000},"page":"e343-e347","source":"Crossref","is-referenced-by-count":83,"title":["Breastfeeding-Associated Hypernatremia: Are We Missing the Diagnosis?"],"prefix":"10.1542","volume":"116","author":[{"given":"Michael L.","family":"Moritz","sequence":"first","affiliation":[{"name":"Division of Nephrology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mioara D.","family":"Manole","sequence":"additional","affiliation":[{"name":"Emergency Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Bogen","sequence":"additional","affiliation":[{"name":"General Academic Pediatrics, Department of Pediatrics, Children's Hospital Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Carlos","family":"Ayus","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"2021120820022176600_R1","doi-asserted-by":"crossref","unstructured":"Scariati PD, Grummer-Strawn LM, Fein SB. A longitudinal analysis of infant morbidity and the extent of breastfeeding in the United States. Pediatrics.\u20081997;99(6). Available at: www.pediatrics.org\/cgi\/content\/full\/99\/6\/e5","DOI":"10.1542\/peds.99.6.e5"},{"key":"2021120820022176600_R2","doi-asserted-by":"crossref","unstructured":"Reynolds A. Breastfeeding and brain development. Pediatr Clin North Am.\u20082001;48:159\u2013171","DOI":"10.1016\/S0031-3955(05)70291-1"},{"key":"2021120820022176600_R3","doi-asserted-by":"crossref","unstructured":"Neifert MR. 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