{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T13:17:27Z","timestamp":1746710247230,"version":"3.40.5"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,1]]},"abstract":"<jats:p>Fetal alcohol syndrome (FAS) is the most common nonhereditary cause of mental retardation, with deficits in general intellectual functioning, learning, memory, attention, and problem-solving. Presented here is the first case in which measured neurocognitive abilities were determined before, during, and after hyperbaric oxygen therapy in a case of FAS involving a teenage male patient. Memory, reaction time, and visual motor speed assessments were compared. After 40 hyperbaric treatments with 100% oxygen at 1.5 atmospheres absolute, the patient\u2019s performance in 6 of 6 categories of the computer-administered test battery improved. Word composite (verbal) scores improved from 55% to 73%, memory composite (visual) scores improved from 38% to 55%, reaction time composites improved from 1.03 to 0.53 seconds, impulse control composite scores improved from 8 to 5, and visual motor speed scores improved from 18.6 to 19.03. The patient\u2019s subjective symptoms diminished 94%. Six months after these treatments, the patient\u2019s verbal memory was maintained at 73% without any other interventions; impulsivity continued to improve, whereas other indices did not. Thirty-three additional treatments continued to improve test performance, with verbal memory at 95%, visual memory at 57%, and a 100% reduction of subjective symptoms. This patient, with 15-year-matured FAS, benefited from a short course of low-pressure hyperbaric oxygen therapy, sustained durable cognitive improvements, and continued to exhibit improvement with another short course of treatments.<\/jats:p>","DOI":"10.1542\/peds.2004-2851","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T00:34:13Z","timestamp":1126830853000},"page":"e586-e591","source":"Crossref","is-referenced-by-count":18,"title":["Quantification of Neurocognitive Changes Before, During, and After Hyperbaric Oxygen Therapy in a Case of Fetal Alcohol Syndrome"],"prefix":"10.1542","volume":"116","author":[{"given":"Kenneth P.","family":"Stoller","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, New Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2021120819503432600_R1","unstructured":"May PA, Gossage JP. 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