{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:32:13Z","timestamp":1793424733453,"version":"4.5.0"},"reference-count":47,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:p>Objective. A number of definitions of bronchopulmonary dysplasia (BPD), or chronic lung disease, have been used. A June 2000 National Institute of Child Health and Human Development\/National Heart, Lung, and Blood Institute Workshop proposed a severity-based definition of BPD for infants &amp;lt;32 weeks\u2019 gestational age (GA). Mild BPD was defined as a need for supplemental oxygen (O2) for \u226528 days but not at 36 weeks\u2019 postmenstrual age (PMA) or discharge, moderate BPD as O2 for \u226528 days plus treatment with &amp;lt;30% O2 at 36 weeks\u2019 PMA, and severe BPD as O2 for \u226528 days plus \u226530% O2 and\/or positive pressure at 36 weeks\u2019 PMA. The objective of this study was to determine the predictive validity of the severity-based, consensus definition of BPD.<\/jats:p>\n                  <jats:p>Methods. Data from 4866 infants (birth weight \u22641000 g, GA &amp;lt;32 weeks, alive at 36 weeks\u2019 PMA) who were entered into the National Institute of Child Health and Human Development Neonatal Research Network Very Low Birth weight (VLBW) Infant Registry between January 1, 1995 and December 31, 1999, were linked to data from the Network Extremely Low Birth Weight (ELBW) Follow-up Program, in which surviving ELBW infants have a neurodevelopmental and health assessment at 18 to 22 months\u2019 corrected age. Linked VLBW Registry and Follow-up data were available for 3848 (79%) infants. Selected follow-up outcomes (use of pulmonary medications, rehospitalization for pulmonary causes, receipt of respiratory syncytial virus prophylaxis, and neurodevelopmental abnormalities) were compared among infants who were identified with BPD defined as O2 for 28 days (28 days definition), as O2 at 36 weeks\u2019 PMA (36 weeks\u2019 definition), and with the consensus definition of BPD.<\/jats:p>\n                  <jats:p>Results. A total of 77% of the neonates met the 28-days definition, and 44% met the 36-weeks definition. Using the consensus BPD definition, 77% of the infants had BPD, similar to the cohort identified by the 28-days definition. A total of 46% of the infants met the moderate (30%) or severe (16%) consensus definition criteria, identifying a similar cohort of infants as the 36-weeks definition. Of infants who met the 28-days definition and 36-weeks definition and were seen at follow-up at 18 to 22 months\u2019 corrected age, 40% had been treated with pulmonary medications and 35% had been rehospitalized for pulmonary causes. In contrast, as the severity of BPD identified by the consensus definition worsened, the incidence of those outcomes and of selected adverse neurodevelopmental outcomes increased in the infants who were seen at follow-up.<\/jats:p>\n                  <jats:p>Conclusion. The consensus BPD definition identifies a spectrum of risk for adverse pulmonary and neurodevelopmental outcomes in early infancy more accurately than other definitions.<\/jats:p>","DOI":"10.1542\/peds.2005-0249","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T15:44:17Z","timestamp":1133451857000},"page":"1353-1360","source":"Crossref","is-referenced-by-count":1022,"title":["Validation of the National Institutes of Health Consensus Definition of Bronchopulmonary Dysplasia"],"prefix":"10.1542","volume":"116","author":[{"given":"Richard A.","family":"Ehrenkranz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty R.","family":"Vohr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Jobe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda L.","family":"Wright","sequence":"additional","affiliation":[{"name":"National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avroy A.","family":"Fanaroff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Wrage","sequence":"additional","affiliation":[{"name":"RTI International, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Poole","sequence":"additional","affiliation":[{"name":"RTI International, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the National Institutes of Child Health and Human Development Neonatal Research Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"2021121003240584000_R1","doi-asserted-by":"crossref","unstructured":"Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline membrane disease: bronchopulmonary dysplasia. N Engl J Med.\u20081967;276:357\u2013368","DOI":"10.1056\/NEJM196702162760701"},{"key":"2021121003240584000_R2","doi-asserted-by":"crossref","unstructured":"Bancalari E, Abdenour GE, Feller R, Gannon J. Bronchopulmonary dysplasia: clinical presentation. J Pediatr.\u20081979;85:819\u2013823","DOI":"10.1016\/S0022-3476(79)80442-4"},{"key":"2021121003240584000_R3","doi-asserted-by":"crossref","unstructured":"Tooley WH. Epidemiology of bronchopulmonary dysplasia. J Pediatr.\u20081979;85:851\u2013855","DOI":"10.1016\/S0022-3476(79)80451-5"},{"key":"2021121003240584000_R4","unstructured":"O\u2019Brodovich HM, Mellins RB. Bronchopulmonary dysplasia: unresolved neonatal acute lung injury. Am Rev Respir Dis.\u20081985;132:694\u2013709"},{"key":"2021121003240584000_R5","doi-asserted-by":"crossref","unstructured":"Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics.\u20081988;82:527\u2013532","DOI":"10.1542\/peds.82.4.527"},{"key":"2021121003240584000_R6","doi-asserted-by":"crossref","unstructured":"Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am Rev Respir Crit Care Med.\u20082001;163:1723\u20131729","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"2021121003240584000_R7","doi-asserted-by":"crossref","unstructured":"Walsh MC, Yao Q, Gettner PA, et al. Impact of a physiologic definition on bronchopulmonary dysplasia rates. Pediatrics.\u20082004;114:1305\u20131311","DOI":"10.1542\/peds.2004-0204"},{"key":"2021121003240584000_R8","unstructured":"Fletcher BD, Wright LL, Oh W, et al. Evaluation of radiographic (CXR) scoring system for predicting outcomes of very low birthweight (VLBW) infants with BPD. Pediatr Res.\u20081993;33:326A"},{"key":"2021121003240584000_R9","unstructured":"Ehrenkranz RA, Verter J, Fanaroff AA, et al. BPD: what\u2019s in a definition?Pediatr Res.\u20081995;37:330A"},{"key":"2021121003240584000_R10","doi-asserted-by":"crossref","unstructured":"Fanaroff AA, Wright LL, Stevenson DK, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol.\u20081995;173:1423\u20131431","DOI":"10.1016\/0002-9378(95)90628-2"},{"key":"2021121003240584000_R11","doi-asserted-by":"crossref","unstructured":"Stevenson DK, Wright LL, Lemons JA, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994. Am J Obstet Gynecol.\u20081998;179:1632\u20131639","DOI":"10.1016\/S0002-9378(98)70037-7"},{"key":"2021121003240584000_R12","doi-asserted-by":"crossref","unstructured":"Lemons JA, Bauer CR, Oh W, et al. 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