{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:23:01Z","timestamp":1773296581732,"version":"3.50.1"},"reference-count":56,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,1]]},"abstract":"<jats:p>BACKGROUND. Animal-derived, protein-containing surfactants seem to be superior to protein-free surfactants. Lucinactant, a synthetic surfactant containing a surfactant protein-B peptide analog, has been shown to be effective in animal models and phase II clinical trials. To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model.<\/jats:p><jats:p>OBJECTIVE. The objective was to compare the acute and sustained effects of lucinactant among premature lambs with respiratory distress syndrome (RDS) with the effects of a natural porcine surfactant (poractant-\u03b1).<\/jats:p><jats:p>METHODS. After 5 minutes of mechanical ventilation twin premature lambs were assigned randomly to the lucinactant group (30 mg\/mL, 5.8 mL\/kg) or the poractant-\u03b1 group (80 mg\/mL, 2.2 mL\/kg). Heart rate, systemic arterial pressure, arterial pH, blood gas values, and lung mechanics were recorded for 12 hours.<\/jats:p><jats:p>RESULTS. Baseline fetal pH values were similar for the 2 groups (pH 7.27). After 5 minutes of mechanical ventilation, severe RDS developed (pH: &amp;lt;7.08; Paco2: &amp;gt;80 mm Hg; Pao2: &amp;lt;40 mm Hg; dynamic compliance: &amp;lt;0.08 mL\/cm H2O per kg). After surfactant instillation, similar improvements in gas exchange and lung mechanics were observed for the lucinactant and poractant-\u03b1 groups at 1 hour (pH: 7.3 \u00b1 0.1 vs 7.4 \u00b1 0.1; Paco2: 8 \u00b1 18 mm Hg vs 40 \u00b1 8 mm Hg; Pao2: 167 \u00b1 52 mm Hg vs 259 \u00b1 51 mm Hg; dynamic compliance: 0.3 \u00b1 0.1 mL\/cm H2O per kg vs 0.3 \u00b1 0.1 mL\/cm H2O per kg). The improvements in lung function were sustained, with no differences between groups. Cardiovascular profiles remained stable in both groups.<\/jats:p><jats:p>CONCLUSIONS. Among preterm lambs with severe RDS, lucinactant produced improvements in gas exchange and lung mechanics similar to those observed with a porcine-derived surfactant.<\/jats:p>","DOI":"10.1542\/peds.2005-0378","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T19:21:17Z","timestamp":1138821677000},"page":"295-303","source":"Crossref","is-referenced-by-count":24,"title":["Acute and Sustained Effects of Lucinactant Versus Poractant-\u03b1 on Pulmonary Gas Exchange and Mechanics in Premature Lambs With Respiratory Distress Syndrome"],"prefix":"10.1542","volume":"117","author":[{"given":"Elena","family":"Gastiasoro-Cuesta","sequence":"first","affiliation":[{"name":"Research Unit for Experimental Neonatal Respiratory Physiology, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Alvarez-Diaz","sequence":"additional","affiliation":[{"name":"Research Unit for Experimental Neonatal Respiratory Physiology, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Rey-Santano","sequence":"additional","affiliation":[{"name":"Research Unit for Experimental Neonatal Respiratory Physiology, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arantxa","family":"Arnaiz-Renedo","sequence":"additional","affiliation":[{"name":"Research Unit for Experimental Neonatal Respiratory Physiology, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begon\u0303a","family":"Loureiro-Gonzalez","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolf","family":"Valls-i-Soler","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2006,2,1]]},"reference":[{"key":"2021120820070521400_R1","doi-asserted-by":"crossref","unstructured":"Avery ME, Mead J. 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