{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:14:50Z","timestamp":1789132490910,"version":"build-2803163510"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:p>OBJECTIVE. To obtain transcutaneous bilirubin (TcB) measurements, at 6-hour intervals, in the first 96 hours after birth in a normal newborn population (gestational age: \u226535 weeks).<\/jats:p><jats:p>METHODS. We performed 9397 TcB measurements on 3984 healthy newborn infants (gestational age: \u226535 weeks) from 6 to 96 hours of age. All measurements were performed in the well-infant nursery with a Draeger Air-Shields transcutaneous jaundice meter (model JM-103), within 2 hours of the designated time.<\/jats:p><jats:p>RESULTS. There was a distinct pattern to the velocity of the increase in TcB levels over different time periods. TcB levels increased in a linear manner most rapidly in the first 6 to 18 hours and then less rapidly from 18 to 42 hours, followed by a much slower increase until peak levels occurred. Decreasing gestational age was associated significantly with higher TcB levels.<\/jats:p><jats:p>CONCLUSIONS. We provide data on neonatal bilirubinemia, based on TcB levels determined in a large, predominately white and breastfed, North American population. Infants who require closer evaluation and observation initially are those whose bilirubin levels are \u226595th percentile, ie, increasing more rapidly than 0.22 mg\/dL per hour in the first 24 hours, 0.15 mg\/dL per hour between 24 and 48 hours, and 0.06 mg\/dL per hour after 48 hours. These data should be useful for detecting aberrant trends, identifying infants who need additional evaluation, and planning appropriate follow-up for jaundiced newborns.<\/jats:p>","DOI":"10.1542\/peds.2005-0744","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T21:23:11Z","timestamp":1144099391000},"page":"1169-1173","source":"Crossref","is-referenced-by-count":99,"title":["Transcutaneous Bilirubin Levels in the First 96 Hours in a Normal Newborn Population of \u226535 Weeks' Gestation"],"prefix":"10.1542","volume":"117","author":[{"given":"M. Jeffrey","family":"Maisels","sequence":"first","affiliation":[{"name":"Department of Pediatrics, William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kring","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"2021120902123040400_R1","unstructured":"Maisels MJ. Jaundice. In: MacDonald MG, Seshia MMK, Mullett MD, eds. Neonatology: Pathophysiology and Management of the Newborn. Philadelphia, PA: Lippincott; 2005:768\u2013846"},{"key":"2021120902123040400_R2","doi-asserted-by":"crossref","unstructured":"Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics.\u20081999;103:6\u201314","DOI":"10.1542\/peds.103.1.6"},{"key":"2021120902123040400_R3","doi-asserted-by":"crossref","unstructured":"Maisels MJ, Baltz RD, Bhutani V, et al. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics.\u20082004;114:297\u2013316","DOI":"10.1542\/peds.114.1.297"},{"key":"2021120902123040400_R4","doi-asserted-by":"crossref","unstructured":"Maisels MJ, Ostrea EJ Jr, Touch S, et al. Evaluation of a new transcutaneous bilirubinometer. Pediatrics.\u20082004;113:1628\u20131635","DOI":"10.1542\/peds.113.6.1628"},{"key":"2021120902123040400_R5","doi-asserted-by":"crossref","unstructured":"Yasuda S, Itoh S, Isobe K, et al. New transcutaneous jaundice device with two optical paths. J Perinat Med.\u20082003;31:81\u201388","DOI":"10.1515\/JPM.2003.012"},{"key":"2021120902123040400_R6","doi-asserted-by":"crossref","unstructured":"Keren R, Bhutani VK, Luan X, Nihtianova S, Cnaan A, Schwartz JS. Identifying newborns at risk of significant hyperbilirubinaemia: a comparison of two recommended approaches. Arch Dis Child.\u20082004;90:415\u2013421","DOI":"10.1136\/adc.2004.060079"},{"key":"2021120902123040400_R7","doi-asserted-by":"crossref","unstructured":"Newman TB, Liljestrand P, Escobar GJ. Combining clinical risk factors with bilirubin levels to predict hyperbilirubinemia in newborns. Arch Pediatr Adolesc Med.\u20082005;159:113\u2013119","DOI":"10.1001\/archpedi.159.2.113"},{"key":"2021120902123040400_R8","doi-asserted-by":"crossref","unstructured":"Alpay F, Sarici S, Tosuncuk HD, Serdar MA, Inanc N, Gokcay E. The value of first-day bilirubin measurement in predicting the development of significant hyperbilirubinemia in healthy term newborns. Pediatrics.\u20082000;106(2). 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