{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:05:30Z","timestamp":1790982330182,"version":"4.1.0"},"reference-count":18,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:p>BACKGROUND. Neonatal hypotension may be a risk factor for neurologic impairment. Few studies have examined the impact of low blood pressure in extremely low birth weight (ELBW) infants weighing 400 to 999 g on neurodevelopmental outcome.<\/jats:p><jats:p>OBJECTIVES. We set out to explore the relationship between treated hypotension in the first 72 hours of life and perinatal factors, morbidity, and mortality in ELBW infants and then to compare neurosensory outcome in ELBW infants with treated hypotension and those who never received treatment for hypotension.<\/jats:p><jats:p>DESIGN\/METHODS. We performed chart review of all 156 ELBW infants admitted to our level III NICU in 1998\u20131999. Infants had \u201ctreated hypotension\u201d if they received fluid pushes, corticosteroids, and\/or vasopressors during the first 72 hours of life in an attempt to increase blood pressure. Follow-up included neurologic examination, Bayley Scales of Infant Development, vision and hearing evaluation. Statistical analysis was performed by using SPSS 11.0. Univariate and multivariate analyses were conducted to determine morbidities associated with treated hypotension.<\/jats:p><jats:p>RESULTS. Fifty-nine infants received treatment for hypotension. Ninety-seven infants did not. The groups had similar race, gender, delivery mode, chorioamnionitis, and maternal socioeconomic status. Thirty-eight (24%) infants expired, including 20 who received treatment for hypotension. Of the 156 infants in the study group, 110 underwent neurodevelopment testing, and 103 were able to undergo complete neurodevelopment testing and Bayley examination. Multivariate analysis controlling for socioeconomic status and neonatal morbidity revealed that treated hypotension is associated with delayed motor development and hearing loss.<\/jats:p><jats:p>CONCLUSIONS. Treated hypotension in ELBW infants in the first 72 hours of life is associated with significant short-term and long-term morbidity. Infants with treated hypotension are more likely to have delayed motor development, hearing loss, and death.<\/jats:p>","DOI":"10.1542\/peds.2005-1230","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T21:23:11Z","timestamp":1144099391000},"page":"1131-1135","source":"Crossref","is-referenced-by-count":134,"title":["Treated Hypotension Is Associated With Neonatal Morbidity and Hearing Loss in Extremely Low Birth Weight Infants"],"prefix":"10.1542","volume":"117","author":[{"given":"Jonathan M.","family":"Fanaroff","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanne E.","family":"Wilson-Costello","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy S.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Montpetite","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avroy A.","family":"Fanaroff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"2021120902112422200_R1","unstructured":"Martin J, Hamilton B, Sutton P, Ventura SJ, Menacker F, Munson ML. Births: final data for 2002. Natl Vital Stat Rep.\u20082003;52(10):1\u2013113"},{"key":"2021120902112422200_R2","doi-asserted-by":"crossref","unstructured":"Vohr BR, Wright LL, Dusick AM, et al. Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993\u20131994. Pediatrics.\u20082000;105:1216\u20131226","DOI":"10.1542\/peds.105.6.1216"},{"key":"2021120902112422200_R3","doi-asserted-by":"crossref","unstructured":"Efird MM, Heerens AT, Gordon PV, Bose CL, Young DA. A randomized-controlled trial of prophylactic hydrocortisone supplementation for the prevention of hypotension in extremely low birth weight infants. J Perinatol.\u20082004;25:119\u2013124","DOI":"10.1038\/sj.jp.7211193"},{"key":"2021120902112422200_R4","doi-asserted-by":"crossref","unstructured":"Watkins AM, West CR, Cooke RW. Blood pressure and cerebral haemorrhage and ischaemia in very low birthweight infants. Early Hum Dev.\u20081989;19:103\u2013110","DOI":"10.1016\/0378-3782(89)90120-5"},{"key":"2021120902112422200_R5","doi-asserted-by":"crossref","unstructured":"Al-Aweel I, Pursley DM, Rubin LP, Shah B, Weisberger S, Richardson DK. Variations in prevalence of hypotension, hypertension, and vasopressor use in NICUs. J Perinatol.\u20082001;21:272\u2013278","DOI":"10.1038\/sj.jp.7210563"},{"key":"2021120902112422200_R6","doi-asserted-by":"crossref","unstructured":"Cordero L, Timan CJ, Waters HH, Sachs LA. Mean arterial pressures during the first 24 hours of life in &lt;600-gram birth weight infants. J Perinatol.\u20082002;22:348\u2013353","DOI":"10.1038\/sj.jp.7210736"},{"key":"2021120902112422200_R7","doi-asserted-by":"crossref","unstructured":"Versmold HT, Kitterman JA, Phibbs RH, Gregory GA, Tooley WH. Aortic blood pressure during the first 12 hours of life in infants with birth weight 610 to 4220 grams. Pediatrics.\u20081981;67:607\u2013613","DOI":"10.1542\/peds.67.5.607"},{"key":"2021120902112422200_R8","unstructured":"Zubrow AB, Hulman S, Kushner H, Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. J Perinatol.\u20081995;15:470\u2013479"},{"key":"2021120902112422200_R9","unstructured":"Spinazzola RM, Harper RG, de Solen M, Lesser M. Blood pressure values in 500- to 750-gram birthweight infants in the fist week of life. J Perinatol.\u20081991;11:147\u2013151"},{"key":"2021120902112422200_R10","doi-asserted-by":"crossref","unstructured":"Munro MJ, Walker AM, Barfield CP. Hypotensive extremely low birth weight infants have reduced cerebral blood flow. Pediatrics.\u20082004;114:1591\u20131596","DOI":"10.1542\/peds.2004-1073"},{"key":"2021120902112422200_R11","doi-asserted-by":"crossref","unstructured":"Ewer AK, Tyler W, Francis A, Drinkall D, Gardosi JO. Excessive volume expansion and neonatal death in preterm infants born at 27\u201328 weeks gestation. Paediatr Perinat Epidemiol.\u20082003;17:180\u2013186","DOI":"10.1046\/j.1365-3016.2003.00474.x"},{"key":"2021120902112422200_R12","doi-asserted-by":"crossref","unstructured":"Ballard PL. Scientific rationale for the use of antenatal glucocorticoids to promote fetal development. NeoReviews.\u20082000;1:e83\u2013e89","DOI":"10.1542\/neo.1-5-e83"},{"key":"2021120902112422200_R13","doi-asserted-by":"crossref","unstructured":"Demarini S, Dollberg S, Hoath SB, Ho M, Donovan EF. Effects of antenatal corticosteroids on blood pressure in very low birth weight infants during the first 24 hours of life. J Perinatol.\u20081999;19:419\u2013425","DOI":"10.1038\/sj.jp.7200245"},{"key":"2021120902112422200_R14","doi-asserted-by":"crossref","unstructured":"Moise AA, Wearden ME, Kozinetz CA, Gest AL, Welty SE, Hansen TN. Antenatal steroids are associated with less need for blood pressure support in extremely premature infants. Pediatrics.\u20081995;95:845\u2013850","DOI":"10.1542\/peds.95.6.845"},{"key":"2021120902112422200_R15","doi-asserted-by":"crossref","unstructured":"Aucott S. Hypotension in the newborn: who needs hydrocortisone?J Perinatol.\u20082005;25:77\u201378","DOI":"10.1038\/sj.jp.7211225"},{"key":"2021120902112422200_R16","unstructured":"Revich M, Brann A, Shapiro HM, et al. Regional cerebral blood flow during prolonged partial asphyxia. In: Meyer JS, Reivich M, Lechner H, et al, eds. Research on the Cerebral Circulation. Springfield, IL: Thomas; 1972"},{"key":"2021120902112422200_R17","doi-asserted-by":"crossref","unstructured":"Young RS, Hernandez MJ, Yagel SK. Selective reduction of blood flow to white matter during hypotension in newborn dogs: a possible mechanism of periventricular leukomalacia. Ann Neurol.\u20081982;12:445\u2013448","DOI":"10.1002\/ana.410120506"},{"key":"2021120902112422200_R18","unstructured":"Volpe JJ. Neurology of the Newborn. 3rd ed. Philadelphia, PA: Saunders; 1995:115"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/117\/4\/1131\/1072841\/zpe00406001131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/117\/4\/1131\/1072841\/zpe00406001131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T22:39:58Z","timestamp":1683412798000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/117\/4\/1131\/70835\/Treated-Hypotension-Is-Associated-With-Neonatal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,1]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,4,1]]},"published-print":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2005-1230","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,1]]}}}