{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:16:26Z","timestamp":1777464986887,"version":"3.51.4"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:p>OBJECTIVES. Newborns delivered before 28 weeks' gestation commonly have white matter lesions on MRI that are associated with adverse neurodevelopmental outcomes. Our objective was to determine the risk factors for MRI-detectable white matter injury in infants delivered before 28 weeks' gestation who were treated with prophylactic indomethacin.<\/jats:p><jats:p>METHODS. This was a prospective cohort study conducted at the intensive care nursery at University of California San Francisco Children's Hospital. Patients included 57 premature newborns between 24 and 27 (+6 days) weeks' gestation at birth (October 1998 to October 2004). We identified perinatal and neonatal risk factors associated with moderate-severe \u201cwhite matter injuries\u201d (T1 signal abnormalities &amp;gt;2 mm or &amp;gt;3 areas of T1 abnormality) and moderate-severe \u201cbrain abnormality\u201d (moderate-severe white matter injuries, any degree of ventriculomegaly, or severe intraventricular hemorrhage) on MRI. Infants were studied with MRI at 31.1 weeks\u2019 postmenstrual age (median).<\/jats:p><jats:p>RESULTS. Moderate-severe white matter injuries were detected in 12 (21%) of 53 preterm newborns, and 20 (35%) of 57 had moderate-severe brain abnormality. Prolonged indomethacin exposure was the only risk factor independently associated with a lower risk of white matter injury or brain abnormality, even when adjusting for the presence of a hemodynamically significant PDA, gestational age at birth, prenatal betamethasone, systemic infection, and days of mechanical ventilation.<\/jats:p><jats:p>CONCLUSIONS. In this observational study, a longer duration of indomethacin exposure was associated with less white matter injury in infants delivered before 28 weeks' gestation. A randomized trial of prolonged indomethacin treatment is needed to determine whether indomethacin can decrease white matter injury and neurodevelopmental abnormalities.<\/jats:p>","DOI":"10.1542\/peds.2005-1767","type":"journal-article","created":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T17:22:05Z","timestamp":1146504125000},"page":"1626-1631","source":"Crossref","is-referenced-by-count":69,"title":["Prolonged Indomethacin Exposure Is Associated With Decreased White Matter Injury Detected With Magnetic Resonance Imaging in Premature Newborns at 24 to 28 Weeks' Gestation at Birth"],"prefix":"10.1542","volume":"117","author":[{"given":"Steven P.","family":"Miller","sequence":"first","affiliation":[{"name":"Departments of Neurology"},{"name":"Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor E.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Radiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald I.","family":"Clyman","sequence":"additional","affiliation":[{"name":"Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David V.","family":"Glidden","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, University of California, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon E.G.","family":"Hamrick","sequence":"additional","affiliation":[{"name":"Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. James","family":"Barkovich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2021120823250190200_R1","unstructured":"Volpe JJ. Neurology of the Newborn. 4 ed. Philadelphia, PA: WB Saunders Company; 2001"},{"key":"2021120823250190200_R2","doi-asserted-by":"crossref","unstructured":"Hamrick SE, Miller SP, Leonard C, et al. Trends in severe brain injury and neurodevelopmental outcome in premature newborn infants: the role of cystic periventricular leukomalacia. J Pediatr.\u20082004;145:593\u2013599","DOI":"10.1016\/j.jpeds.2004.05.042"},{"key":"2021120823250190200_R3","doi-asserted-by":"crossref","unstructured":"Miller SP, Ferriero DM, Leonard C, et al. 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