{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:56:17Z","timestamp":1791039377511,"version":"4.1.0"},"reference-count":37,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:p>BACKGROUND. Venous thrombosis (VT) in children with Staphylococcus aureus osteomyelitis occurs rarely. We describe clinical features of infections and molecular characterization of isolates of children at Texas Children's Hospital with S aureus osteomyelitis and VT.<\/jats:p>\n               <jats:p>METHODS. We reviewed records and imaging studies (chest radiographs, ultrasound, computed tomography, and MRI) of 9 patients at Texas Children's Hospital with acute S aureus osteomyelitis and new onset VT between August 1999 and December 2004. Isolates were fingerprinted by pulsed-field gel electrophoresis and tested for the presence of genes encoding selective virulence factors.<\/jats:p>\n               <jats:p>RESULTS. The mean age of the patients was 10.6 years. All 9 of the patients had osteomyelitis with sites of infection adjacent to the VT. The femoral and popliteal veins were most commonly affected. Two patients had VTs develop on the same side in which a central line had been in place. Four patients had chest radiographs consistent with septic emboli; inferior vena cava filters were placed in 3. Evaluation for hypercoagulable state revealed 3 patients with lupus anticoagulant, 1 with anticardiolipin IgG antibody, and 5 with no defect. Most laboratory abnormalities had resolved at follow-up. Seven patients had infections caused by methicillin-resistant S aureus belonging to the same clonal group (USA300); all were community acquired. Seven isolates carried the Panton-Valentine leukocidin (luk-S-PV and luk-F-PV) genes.<\/jats:p>\n               <jats:p>CONCLUSIONS. The predominant community-acquired, methicillin-resistant S aureus clone in Houston, Texas, (USA300) may have a unique propensity to cause VT in association with osteomyelitis. Management of the venous thrombosis in this setting may be complicated by the rapid evolution of septic emboli.<\/jats:p>","DOI":"10.1542\/peds.2005-2009","type":"journal-article","created":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T17:22:05Z","timestamp":1146504125000},"page":"1673-1679","source":"Crossref","is-referenced-by-count":193,"title":["Venous Thrombosis Associated With Staphylococcal Osteomyelitis in Children"],"prefix":"10.1542","volume":"117","author":[{"given":"Blanca E.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Teruya","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Pathology, Baylor College of Medicine, Houston, Texas"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Donald H.","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina G.","family":"Hulten","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Edwards","sequence":"additional","affiliation":[{"name":"Pathology, Baylor College of Medicine, Houston, Texas"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda B.","family":"Lamberth","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Hammerman","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Edward O.","family":"Mason","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2021120823271153200_R1","doi-asserted-by":"crossref","unstructured":"Nowak-Gottl U, Kosch A. Factor VIII, D-dimer, and thromboembolism in children. N Engl J Med.\u20082004;351;1051\u20131053","DOI":"10.1056\/NEJMp048150"},{"key":"2021120823271153200_R2","doi-asserted-by":"crossref","unstructured":"Stein PD, Kayali F, Olson RE. Incidence of venous thromboembolism in infants and children: data from the National Hospital Discharge Survey. J Pediatr.\u20082004;145:563\u2013565","DOI":"10.1016\/j.jpeds.2004.06.021"},{"key":"2021120823271153200_R3","doi-asserted-by":"crossref","unstructured":"Chan AK, Deveber G, Monagle P, Brooker LA, Massicotte PM. Venous thrombosis in children. J Thromb Haemost.\u20082003;1:1443\u20131455","DOI":"10.1046\/j.1538-7836.2003.00308.x"},{"key":"2021120823271153200_R4","doi-asserted-by":"crossref","unstructured":"Horvath FL, Brodeur AE, Cherry JD. Deep thrombophlebitis associated with acute osteomyelitis. J Pediatr.\u20081971;79:815\u2013818","DOI":"10.1016\/S0022-3476(71)80399-2"},{"key":"2021120823271153200_R5","doi-asserted-by":"crossref","unstructured":"Jupiter JB, Ehrlich MG, Novelline RA, Leeds HC, Keim D. The association of septic thrombophlebitis with subperiosteal abscesses in children. J Pediatr.\u20081982;101:690\u2013695","DOI":"10.1016\/S0022-3476(82)80292-8"},{"key":"2021120823271153200_R6","unstructured":"von Muhlendahl KE. Pelvic and femoral vein thrombosis in childhood [in German]. Monatsschr Kinderheilkd.\u20081988;136:397\u2013399"},{"key":"2021120823271153200_R7","doi-asserted-by":"crossref","unstructured":"Letts M, Lalonde F, Davidson D, Hosking M, Halton J. Atrial and venous thrombosis secondary to septic arthritis of the sacroiliac joint in a child with hereditary protein C deficiency. J Pediatr Orthop.\u20081999;19:156\u2013160","DOI":"10.1097\/01241398-199903000-00004"},{"key":"2021120823271153200_R8","doi-asserted-by":"crossref","unstructured":"Smith L, Hamill J, Metcalf R, Walsh S. Caval thrombectomy for severe staphylococcal osteomyelitis. J Pediatr Surg.\u20081997;32:112\u2013114","DOI":"10.1016\/S0022-3468(97)90111-1"},{"key":"2021120823271153200_R9","doi-asserted-by":"crossref","unstructured":"Gorenstein A, Gross E, Houri S, Gewirts G, Katz S. The pivotal role of deep vein thrombophlebitis in the development of acute disseminated staphylococcal disease in children. Pediatrics.\u20082000;106(6). Available at: www.pediatrics.org\/cgi\/content\/full\/106\/6\/e87","DOI":"10.1542\/peds.106.6.e87"},{"key":"2021120823271153200_R10","doi-asserted-by":"crossref","unstructured":"Walsh S, Phillips F. Deep vein thrombosis associated with pediatric musculoskeletal sepsis. J Pediatr Orthop.\u20082002;22:329\u2013332","DOI":"10.1097\/01241398-200205000-00011"},{"key":"2021120823271153200_R11","doi-asserted-by":"crossref","unstructured":"Newgard CD, Inkelis SH, Mink R. Septic thromboembolism from unrecognized deep venous thrombosis in a child. Pediatr Emerg Care.\u20082002;18:192\u2013196","DOI":"10.1097\/00006565-200206000-00011"},{"key":"2021120823271153200_R12","doi-asserted-by":"crossref","unstructured":"Yuksel H, Ozguven AA, Akil I, Erguder I, Yilmaz D, Cabuk M. Septic pulmonary emboli presenting with deep venous thrombosis secondary to acute osteomyelitis. Pediatr Int.\u20082004;46:621\u2013623","DOI":"10.1111\/j.1442-200x.2004.01952.x"},{"key":"2021120823271153200_R13","unstructured":"Knockaert DC, Morren GL, Feys CM, Cox EJ, Rommens PM. Septic sacroiliitis [in Dutch]. Ned Tijdschr Geneeskd.\u20081989;133:895\u2013899"},{"key":"2021120823271153200_R14","doi-asserted-by":"crossref","unstructured":"Gonzalez BE, Martinez-Aguilar G, Hulten KG, et al. Severe staphylococcal sepsis in adolescents in the era of community-acquired methicillin-resistant Staphylococcus aureus.Pediatrics.\u20082005;115:642\u2013648","DOI":"10.1542\/peds.2004-2300"},{"key":"2021120823271153200_R15","doi-asserted-by":"crossref","unstructured":"Miller LG, Perdreau-Remington F, Rieg G, et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med.\u20082005;352:1445\u20131453","DOI":"10.1056\/NEJMoa042683"},{"key":"2021120823271153200_R16","doi-asserted-by":"crossref","unstructured":"Francis JS, Doherty MC, Lopatin U, et al. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin Infect Dis.\u20082005;40:100\u2013107","DOI":"10.1086\/427148"},{"key":"2021120823271153200_R17","doi-asserted-by":"crossref","unstructured":"Kravitz GR, Dries DJ, Peterson ML, Schlievert PM. Purpura fulminans due to Staphylococcus aureus.Clin Infect Dis.\u20082005;40:941\u2013947","DOI":"10.1086\/428573"},{"key":"2021120823271153200_R18","doi-asserted-by":"crossref","unstructured":"Mongkolrattanothai K, Boyle S, Kahana MD, Daum RS. Severe Staphylococcus aureus infections caused by clonally related community-acquired methicillin-susceptible and methicillin-resistant isolates. Clin Infect Dis.\u20082003;37:1050\u20131058","DOI":"10.1086\/378277"},{"key":"2021120823271153200_R19","doi-asserted-by":"crossref","unstructured":"Mishaan AMA, Mason EO, Martinez-Aguilar G, et al. Emergence of a predominant clone of community acquired Staphylococcus aureus among children in Houston, TX. Pediatr Infect Dis J.\u20082005;24:201\u2013206","DOI":"10.1097\/01.inf.0000151107.29132.70"},{"key":"2021120823271153200_R20","doi-asserted-by":"crossref","unstructured":"Kaplan SL, Hulten KG, Gonzalez BE, et al. Three year surveillance of community-acquired Staphylococcus aureus infections in children. Clin Infect Dis.\u20082005;40:1785\u20131791","DOI":"10.1086\/430312"},{"key":"2021120823271153200_R21","doi-asserted-by":"crossref","unstructured":"Moore PC, Lindsay JA. Genetic variation among hospital isolates of methicillin-sensitive Staphylococcus aureus: evidence for horizontal transfer of virulence genes. J Clin Microbiol.\u20082001;39:2760\u20132767","DOI":"10.1128\/JCM.39.8.2760-2767.2001"},{"key":"2021120823271153200_R22","doi-asserted-by":"crossref","unstructured":"Okuma K, Iwakawa K, Turnidge JD, et al. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol.\u20082002;40:4289\u20134294","DOI":"10.1128\/JCM.40.11.4289-4294.2002"},{"key":"2021120823271153200_R23","doi-asserted-by":"crossref","unstructured":"Murray BE, Singh KV, Heath JD, Sharma BR, Weinstock GM. Comparison of genomic DNAs of different enterococcal isolates using restriction endonucleases with infrequent recognition sites. J Clin Microbiol.\u20081990;28:2059\u20132063","DOI":"10.1128\/jcm.28.9.2059-2063.1990"},{"key":"2021120823271153200_R24","doi-asserted-by":"crossref","unstructured":"Murchan S, Kaufmann ME, Deplano A, et al. Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: a single approach developed by consensus in 10 European laboratories and its application for tracing the spread of related strains. J Clin Microbiol.\u20082003;41:1574\u20131585","DOI":"10.1128\/JCM.41.4.1574-1585.2003"},{"key":"2021120823271153200_R25","doi-asserted-by":"crossref","unstructured":"Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol.\u20081995;33:2233\u20132239","DOI":"10.1128\/jcm.33.9.2233-2239.1995"},{"key":"2021120823271153200_R26","doi-asserted-by":"crossref","unstructured":"Male C, Chait P, Andrew M, Hanna K, Julian J, Mitchell L. Central venous line-related thrombosis in children: association with central venous line location and insertion technique. Blood.\u20082003;101:4273\u20134278","DOI":"10.1182\/blood-2002-09-2731"},{"key":"2021120823271153200_R27","doi-asserted-by":"crossref","unstructured":"Diep BA, Sensabaugh GF, Somboona NS, Carleton HA, Perdreau-Remington F. Widespread skin and soft-tissue infections due to 2 methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin. J Clin Microbiol.\u20082004;42:2080\u20132084","DOI":"10.1128\/JCM.42.5.2080-2084.2004"},{"key":"2021120823271153200_R28","doi-asserted-by":"crossref","unstructured":"Martinez-Aguilar G, Avalos-Mishaan A, Hulten K, Hammerman W, Mason EO, Jr, Kaplan SL. Community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus musculoskeletal infections in children. Pediatr Infect Dis J.\u20082004;23:701\u2013706","DOI":"10.1097\/01.inf.0000133044.79130.2a"},{"key":"2021120823271153200_R29","doi-asserted-by":"crossref","unstructured":"Goldenberg NA, Knapp-Clevenger R, Manco-Johnson MJ. Elevated plasma factor VIII and D-dimer levels as predictors of poor outcomes of thrombosis in children. N Engl J Med.\u20082004;351:1081\u20131088","DOI":"10.1056\/NEJMoa040161"},{"key":"2021120823271153200_R30","doi-asserted-by":"crossref","unstructured":"Johnson AS, Bolte RG. Pulmonary embolism in the pediatric patient. Pediatr Emerg Care.\u20082004;20:555\u2013560","DOI":"10.1097\/01.pec.0000136076.60445.3c"},{"key":"2021120823271153200_R31","doi-asserted-by":"crossref","unstructured":"Andrew M, David M, Adams M, et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood.\u20081994;83:1251\u20131257","DOI":"10.1182\/blood.V83.5.1251.1251"},{"key":"2021120823271153200_R32","doi-asserted-by":"crossref","unstructured":"Gonzalez BE, Hulten KG, Dishop ME, et al. Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infections. Clin Infect Dis.\u20082005;41:583\u2013590","DOI":"10.1086\/432475"},{"key":"2021120823271153200_R33","doi-asserted-by":"crossref","unstructured":"Greenfield LJ, Proctor MC. Vena caval filter use in patients with sepsis: results in 175 patients. Arch Surg.\u20082003;138:1245\u20131248","DOI":"10.1001\/archsurg.138.11.1245"},{"key":"2021120823271153200_R34","doi-asserted-by":"crossref","unstructured":"Cahn MD, Rohrer MJ, Martella MB, Cutler BS. Long-term follow-up of Greenfield inferior vena cava filter placement in children. J Vasc Surg.\u20082001;34:820\u2013825","DOI":"10.1067\/mva.2001.118801"},{"key":"2021120823271153200_R35","doi-asserted-by":"crossref","unstructured":"Bocchini CE, Hulten KG, Mason EO, et al. Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children. Pediatrics.\u20082006;117:433\u2013440.","DOI":"10.1542\/peds.2005-0566"},{"key":"2021120823271153200_R36","doi-asserted-by":"crossref","unstructured":"Anton N, Massicotte MP. Venous thromboembolism in pediatrics. Semin Vasc Med.\u20082001;1:111\u2013122","DOI":"10.1055\/s-2001-14548"},{"key":"2021120823271153200_R37","doi-asserted-by":"crossref","unstructured":"Talbott GA, Winters WD, Bratton SL, O'Rourke PP. A prospective study of femoral catheter-related thrombosis in children. Arch Pediatr Adolesc Med.\u20081995;149:288\u2013291","DOI":"10.1001\/archpedi.1995.02170150068012"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/117\/5\/1673\/1070068\/zpe00506001673.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/117\/5\/1673\/1070068\/zpe00506001673.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T04:01:09Z","timestamp":1639022469000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/117\/5\/1673\/70069\/Venous-Thrombosis-Associated-With-Staphylococcal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,1]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2006,5,1]]},"published-print":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2005-2009","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,1]]}}}