{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:54:19Z","timestamp":1771383259159,"version":"3.50.1"},"reference-count":11,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:p>OBJECTIVES. Pityriasis rosea (PR) is a common skin disorder in children. Its cause is unknown. A recent publication reported a 73% cure rate in patients with PR after treatment with erythromycin. To duplicate this result using a drug with fewer adverse effects and greater biological half-life, we set out to study the effect of azithromycin on PR. Azithromycin is an azalide antibiotic with a spectrum of antimicrobial activity very similar to that of erythromycin.<\/jats:p><jats:p>DESIGN. We randomly assigned 49 children with PR to receive either azithromycin (12 mg\/kg per day, up to a maximum of 500 mg\/day) for 5 days or a similar-appearing placebo. Study physicians were blinded to patients' treatment type. Two pediatricians had to agree on the diagnosis of PR before patients could be enrolled. Subjects were seen at follow-up visits 1, 2, and 4 weeks after starting treatment.<\/jats:p><jats:p>OUTCOME MEASURES. We measured the appearance of new lesions and resolution of lesions.<\/jats:p><jats:p>RESULTS. Rates of cure and of partial resolution were similar in the azithromycin and placebo groups.<\/jats:p><jats:p>CONCLUSION. Azithromycin does not cure PR.<\/jats:p>","DOI":"10.1542\/peds.2005-2450","type":"journal-article","created":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T17:22:05Z","timestamp":1146504125000},"page":"1702-1705","source":"Crossref","is-referenced-by-count":35,"title":["Azithromycin Does Not Cure Pityriasis Rosea"],"prefix":"10.1542","volume":"117","author":[{"given":"Ahdi","family":"Amer","sequence":"first","affiliation":[{"name":"Wayne State University School of Medicine, the Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Fischer","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, the Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2021120823265054800_R1","unstructured":"Hurwitz S. 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