{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:37:56Z","timestamp":1770431876705,"version":"3.49.0"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:p>We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous,widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-\u03b1 for 6 months without any adverse effect.<\/jats:p>","DOI":"10.1542\/peds.2005-2706","type":"journal-article","created":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T00:18:57Z","timestamp":1146529137000},"page":"e1253-1255","source":"Crossref","is-referenced-by-count":18,"title":["Interferon-\u03b1 Treatment of Molluscum Contagiosum in a Patient With Hyperimmunoglobulin E Syndrome"],"prefix":"10.1542","volume":"117","author":[{"given":"Sara Sebnem","family":"Kilic","sequence":"first","affiliation":[{"name":"Immunology Unit, Department of Pediatrics, Uludag University School of Medicine, Bursa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Kilicbay","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Pediatrics, Uludag University School of Medicine, Bursa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"2021120823013827300_R1","doi-asserted-by":"crossref","unstructured":"Grimbacher B, Holland SM, Gallin JI, et al. Hyper-IgE syndrome with recurrent infections: an autosomal dominant multisystem disorder. N Engl J Med.\u20081999;340:692\u2013702","DOI":"10.1056\/NEJM199903043400904"},{"key":"2021120823013827300_R2","doi-asserted-by":"crossref","unstructured":"Grimbacher B, Schaffer AA, Holland SM, et al. Genetic linkage of hyper-IgE syndrome to chromosome 4. Am J Hum Genet.\u20081999;65:735\u2013744","DOI":"10.1086\/302547"},{"key":"2021120823013827300_R3","doi-asserted-by":"crossref","unstructured":"Husar K, Skerlev M. Molluscum contagiosum from infancy to maturity. Clin Dermatol.\u20082002;20:170\u2013172","DOI":"10.1016\/S0738-081X(02)00209-2"},{"key":"2021120823013827300_R4","doi-asserted-by":"crossref","unstructured":"Silverberg N. Pediatric molluscum contagiosum: optimal treatment strategies. Paediatr Drugs.\u20082003;5:505\u2013512","DOI":"10.2165\/00148581-200305080-00001"},{"key":"2021120823013827300_R5","doi-asserted-by":"crossref","unstructured":"Nelson MR, Chard S, Barton SE. 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