{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:17:21Z","timestamp":1780337841400,"version":"3.54.1"},"reference-count":42,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:p>OBJECTIVES. Little is known about the health effects of living in close proximity to industrial swine operations. We assessed the relationship between estimated exposure to airborne effluent from confined swine feeding operations and asthma symptoms among adolescents who were aged 12 to 14 years.<\/jats:p><jats:p>METHODS. During the 1999\u20132000 school year, 58169 adolescents in North Carolina answered questions about their respiratory symptoms, allergies, medications, socioeconomic status, and household environments. To estimate the extent to which these students may have been exposed during the school day to air pollution from confined swine feeding operations, we used publicly available data about schools (n = 265) and swine operations (n = 2343) to generate estimates of exposure for each public school. Prevalence ratios and 95% confidence intervals for wheezing within the past year were estimated using random-intercepts binary regression models, adjusting for potential confounders, including age, race, socioeconomic status, smoking, school exposures, and household exposures.<\/jats:p><jats:p>RESULTS. The prevalence of wheezing during the past year was slightly higher at schools that were estimated to be exposed to airborne effluent from confined swine feeding operations. For students who reported allergies, the prevalence of wheezing within the past year was 5% higher at schools that were located within 3 miles of an operation relative to those beyond 3 miles and 24% higher at schools in which livestock odor was noticeable indoors twice per month or more relative to those with no odor.<\/jats:p><jats:p>CONCLUSIONS. Estimated exposure to airborne pollution from confined swine feeding operations is associated with adolescents\u2019 wheezing symptoms.<\/jats:p>","DOI":"10.1542\/peds.2005-2812","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T16:42:48Z","timestamp":1152204168000},"page":"e66-e75","source":"Crossref","is-referenced-by-count":83,"title":["Asthma Symptoms Among Adolescents Who Attend Public Schools That Are Located Near Confined Swine Feeding Operations"],"prefix":"10.1542","volume":"118","author":[{"given":"Maria C.","family":"Mirabelli","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Wing","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health"},{"name":"University of North Carolina Injury Prevention Research Center"},{"name":"Department of Orthopedics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wilcosky","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health"},{"name":"Environmental Health and Epidemiology Program, RTI International, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"2021120823053858400_R1","doi-asserted-by":"crossref","unstructured":"Thu KM. 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Respiratory morbidity in relationship to farm characteristics in swine confinement work: possible preventive measures. Am J Ind Med.\u20081995;30:212\u2013218","DOI":"10.1002\/(SICI)1097-0274(199608)30:2<212::AID-AJIM13>3.0.CO;2-#"},{"key":"2021120823053858400_R8","doi-asserted-by":"crossref","unstructured":"Radon K, Weber C, Iversen M, Danuser B, Pedersen S, Nowak D. Exposure assessment and lung function in pig and poultry farmers. Occup Environ Med.\u20082001;58:405\u2013410","DOI":"10.1136\/oem.58.6.405"},{"key":"2021120823053858400_R9","doi-asserted-by":"crossref","unstructured":"Heederik D, Brouwer R, Biersteker K, Boleij JS. Relationship of airborne endotoxin and bacteria levels in pig farms with the lung function and respiratory symptoms of farmers. Int Arch Occup Environ Health.\u20081991;62:595\u2013601","DOI":"10.1007\/BF00381114"},{"key":"2021120823053858400_R10","unstructured":"Haglind P, Rylander R. 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J Agric Saf Health.\u20081997;3:13\u201326","DOI":"10.13031\/2013.17747"},{"key":"2021120823053858400_R14","doi-asserted-by":"crossref","unstructured":"Thu KM. Public health concerns for neighbors of large-scale swine production operations. J Agric Saf Health.\u20082002;8:175\u2013184","DOI":"10.13031\/2013.8430"},{"key":"2021120823053858400_R15","doi-asserted-by":"crossref","unstructured":"Schiffman SS, Miller EA, Suggs MS, Graham BG. The effect of environmental odors emanating from commercial swine operations on the mood of nearby residents. Brain Res Bull.\u20081995;37:369\u2013375","DOI":"10.1016\/0361-9230(95)00015-1"},{"key":"2021120823053858400_R16","doi-asserted-by":"crossref","unstructured":"Sotir M, Yeatts K, Shy C. Presence of asthma risk factors and environmental exposures related to upper respiratory infection-triggered wheezing in middle school-age children. 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