{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:53:49Z","timestamp":1762001629426,"version":"3.40.5"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:p>Sirenomelia is an extremely complex and rare malformation with different degrees of lower-extremities fusion associated with gastrointestinal, musculoskeletal, vascular, cardiopulmonary, and central nervous system malformations. In the English literature, there are only 5 reports of infants surviving with this condition. In our case, a 2540-g female infant was born with normal vital signs, no facial dysmorphism, and a complete soft tissue fusion of the lower limbs, from perineum to ankles. Radiologic examinations revealed an intestinal atresia and a single pelvic kidney, with a unique ureter, 2 femurs, 2 tibias, 2 fibulas, and 2 feet (simpus dipus). At 7 months of age, a multidisciplinary surgical team achieved complete separation of the lower limbs, with independent vascular and nerve supplies. At the time of this writing, the infant was 28 months old and had a regular growth curve. Many future reconstructive surgeries have been planned to achieve an acceptable quality of life for this infant.<\/jats:p>","DOI":"10.1542\/peds.2005-3001","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T00:46:47Z","timestamp":1151369207000},"page":"e220-e223","source":"Crossref","is-referenced-by-count":20,"title":["Multidisciplinary Surgical Approach to a Surviving Infant With Sirenomelia"],"prefix":"10.1542","volume":"118","author":[{"given":"Antonio","family":"Messineo","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery and Burn Unit, Anna Meyer Children's Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Department of Microsurgery, Careggi Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Gelli","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, S. Maria Annunziata Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Pancani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Burn Unit, Anna Meyer Children's Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Lo Piccolo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Burn Unit, Anna Meyer Children's Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Burn Unit, Anna Meyer Children's Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"2021120823072916000_R1","doi-asserted-by":"crossref","unstructured":"Martinez-Frias ML, Garcia A, Bermejo E. Cyclopia and sirenomelia in a liveborn infant [letter]. J Med Genet.\u20081998;35:263\u2013264","DOI":"10.1136\/jmg.35.3.263-a"},{"key":"2021120823072916000_R2","doi-asserted-by":"crossref","unstructured":"Shiesser M, Holzgreve W, Lapaire O, et al. Sirenomelia, the mermaid syndrome: detection in the first trimester. Prenat Diagn.\u20082003;23:493\u2013495","DOI":"10.1002\/pd.624"},{"key":"2021120823072916000_R3","doi-asserted-by":"crossref","unstructured":"Carbillon L, Seince N, Largilliere C, et al. First trimester diagnosis of sirenomelia: a case report. Fetal Diagn Ther.\u20082001;16:284\u2013288","DOI":"10.1159\/000053929"},{"key":"2021120823072916000_R4","unstructured":"Duhamel B. L'ectrourieproprement dite. In: Duhamel B, ed. Morphogenese Pathologique. Paris, France: Masson; 1996:165\u2013172"},{"key":"2021120823072916000_R5","doi-asserted-by":"crossref","unstructured":"Savader SJ, Savader BL, Clark RA. Sirenomelia without Potter syndrome: MR characteristics. 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