{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:42:04Z","timestamp":1787236924191,"version":"build-2736575974"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:p>OBJECTIVES. The aim of this study was to evaluate whether a resuscitation strategy based on administration of 40% oxygen influences mortality rates and rates of improvement in 5-minute Apgar scores, compared with a strategy based on 100% oxygen administration.<\/jats:p>\n                  <jats:p>METHODS. A population-based study evaluated data from 4 Swedish perinatal level III centers during the period of 1998 to 2003. During this period, the centers used either of 2 resuscitation strategies (initial oxygen administration of 40% or 100%). Live-born, singleton, term infants with 1-minute Apgar scores of &amp;lt;4, with a birth weight appropriate for gestational age, and without major malformations were included in the study (n = 1223).<\/jats:p>\n                  <jats:p>RESULTS. Infants born in hospitals using a 40% oxygen strategy had a more rapid Apgar score increase than did infants born in hospitals using a 100% oxygen strategy; however, no difference remained at 10 minutes. The mean Apgar score increased from 2.01 at 1 minute to 6.74 at 5 minutes in the 2 hospitals initiating resuscitation with 40% oxygen, compared with 2.01 to 6.38 in the 2 hospitals using 100% oxygen, with a mean difference in Apgar score increases of 0.36. At 5 minutes, 44.3% of infants born in the hospitals using 100% oxygen had an Apgar score of &amp;lt;7, compared with 34.0% of infants at the hospitals using 40% oxygen. At 10 minutes, the mean Apgar scores were 8.16 at the hospitals using 40% oxygen and 8.07 at the hospitals using 100% oxygen. There were no significant differences in rates of neonatal death, hypoxic ischemic encephalopathy, or seizures in relation to the 2 oxygen strategies.<\/jats:p>\n                  <jats:p>CONCLUSION. Severely depressed term infants born in hospitals initiating resuscitation with 40% oxygen had earlier Apgar score recovery than did infants born in hospitals using a 100% oxygen strategy.<\/jats:p>","DOI":"10.1542\/peds.2006-0102","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:33:20Z","timestamp":1164976400000},"page":"e1798-e1804","source":"Crossref","is-referenced-by-count":14,"title":["Earlier Apgar Score Increase in Severely Depressed Term Infants Cared for in Swedish Level III Units With 40% Oxygen Versus 100% Oxygen Resuscitation Strategies: A Population-Based Register Study"],"prefix":"10.1542","volume":"118","author":[{"given":"Lena","family":"Hellstro\u0308m-Westas","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Forsblad","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Sjo\u0308rs","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Helsingborg Hospital, Helsingborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars J.","family":"Bjo\u0308rklund","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Mars\u030ca\u0301l","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research, Faculty Division of Medicine, Rikshospitalet Medical Center, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Ka\u0308lle\u0301n","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Research Center, Tornblad Institute, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"2021120823125374300_R1","doi-asserted-by":"crossref","unstructured":"Niermeyer S, Kattwinkel J, Van Reempts P, et al. 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