{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:19:21Z","timestamp":1783977561946,"version":"3.55.0"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:p>OBJECTIVES. We conducted this study to assess the rate of methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in methicillin-resistant S aureus\u2013endemic NICUs.<\/jats:p>\n               <jats:p>METHODS. Between March 2003 and February 2004, surveillance culture specimens from the nares, postauricular areas, axillae, and umbilicus of infants admitted to the NICUs at a children\u2019s hospital in Taiwan were obtained weekly for the detection of methicillin-resistant S aureus. All colonized and clinical isolates from each study infant with methicillin-resistant S aureus infection were genotyped with pulsed-field gel electrophoresis, with Sma1 digestion, and compared.<\/jats:p>\n               <jats:p>RESULTS. A total of 783 infants were included in this study. Methicillin-resistant S aureus colonization was detected for 323 infants during their NICU stays, with detection with the first 2 samples for 89%. Nares and umbilicus were the 2 most common sites of initial colonization. Methicillin-resistant S aureus colonization was associated significantly with premature birth (\u226428 weeks) and low birth weight (\u22641500 g), and infants with colonization had a significantly higher rate of methicillin-resistant S aureus infection, compared with those without colonization (26% vs 2%). Methicillin-resistant S aureus colonization was noted for 84 of 92 infants with methicillin-resistant S aureus infections. Of the 68 episodes with previous colonization and isolates available for genotyping analysis, colonized and clinical isolates were indistinguishable in 63 episodes, highly related in 2 episodes, and distinct in 3 episodes.<\/jats:p>\n               <jats:p>CONCLUSIONS. More than 40% of the hospitalized infants were colonized with methicillin-resistant S aureus during their stay in methicillin-resistant S aureus\u2013endemic NICUs; this was associated significantly with methicillin-resistant S aureus infection. Most infants with methicillin-resistant S aureus infections had previous colonization with an indistinguishable strain.<\/jats:p>","DOI":"10.1542\/peds.2006-0254","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T17:07:56Z","timestamp":1154538476000},"page":"469-474","source":"Crossref","is-referenced-by-count":156,"title":["Methicillin-Resistant <i>Staphylococcus aureus<\/i> Colonization and Its Association With Infection Among Infants Hospitalized in Neonatal Intensive Care Units"],"prefix":"10.1542","volume":"118","author":[{"given":"Yhu-Chering","family":"Huang","sequence":"first","affiliation":[{"name":"Divisions of Pediatric Infectious Diseases"},{"name":"School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hong","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Neonatology, Chang Gung Children\u2019s Hospital, Kweishan, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Hui","family":"Su","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Department of Clinical Pathology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rey-In","family":"Lien","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Neonatology, Chang Gung Children\u2019s Hospital, Kweishan, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzou-Yien","family":"Lin","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Infectious Diseases"},{"name":"School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"key":"2021120822380308200_R1","doi-asserted-by":"crossref","unstructured":"Wertheim HFL, Vos M, Ott A, et al. 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