{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:58:30Z","timestamp":1790056710307,"version":"4.0.1"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:p>The hyper\u2013immunoglobulin E syndrome is a primary immunodeficiency characterized by recurrent pyogenic skin and lung abscesses, dermatitis, and elevated serum immunoglobulin E levels. Pneumocystis jiroveci (formerly Pneumocystis carinii) is not typically associated with hyper\u2013immunoglobulin E syndrome. We identified 7 patients with hyper\u2013immunoglobulin E syndrome with P jiroveci detected in respiratory or pulmonary pathology specimens. In 5 patients it was the sole pathogen, and in 2 other patients it contributed to a polymicrobial etiology. No consistent prophylaxis was given, and there have been no recurrences on long-term follow-up. Our experience suggests that P jiroveci can cause pneumonia in patients with hyper\u2013immunoglobulin E syndrome both with and without chronic lung disease.<\/jats:p>","DOI":"10.1542\/peds.2006-0311","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T02:10:19Z","timestamp":1156817419000},"page":"e1271-e1275","source":"Crossref","is-referenced-by-count":55,"title":["<i>Pneumocystis jiroveci<\/i>Infection in Patients With Hyper\u2013Immunoglobulin E Syndrome"],"prefix":"10.1542","volume":"118","author":[{"given":"Alexandra F.","family":"Freeman","sequence":"first","affiliation":[{"name":"National Institute of Allergy and Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joie","family":"Davis","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Barson","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Columbus Children's Hospital, Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk N.","family":"Darnell","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Puck","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Holland","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,10,1]]},"reference":[{"key":"2021120822424673600_R1","doi-asserted-by":"crossref","unstructured":"Buckley RH, Wray BB, Belmaker EZ. 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