{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:09:42Z","timestamp":1790917782238,"version":"4.1.0"},"reference-count":20,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:p>OBJECTIVE. Pulmonary atresia with intact ventricular septum is a complex congenital cardiovascular anomaly that frequently requires single ventricle palliation. Fetal diagnosis of pulmonary atresia with intact ventricular septum is common, but the natural history of pulmonary atresia with intact ventricular septum diagnosed in midgestation, predictors of neonatal anatomy, and predictors of biventricular repair have not been determined. The objective of this study was to determine whether the size and rate of growth of the fetal tricuspid valve predict neonatal anatomy and biventricular repair.<\/jats:p>\n               <jats:p>DESIGN AND RESULTS. Twenty-three fetuses diagnosed with pulmonary atresia with intact ventricular septum between 1990 and 2004 were studied. Of 13 fetuses with a midgestation fetal tricuspid valve z score \u2264\u22123, 1 achieved biventricular repair, compared with 5 of 5 with a tricuspid valve z score &amp;gt;\u22123. Of 13 fetuses with a midgestation fetal tricuspid valve z score \u2264\u22123, 8 were diagnosed postnatally with a right ventricular dependent coronary circulation, compared with none with a tricuspid valve z score &amp;gt;\u22123. Midgestation and late gestation fetal tricuspid valve z scores correlated with neonatal tricuspid valve z score. The average rate of tricuspid valve growth between mid- and late fetal echocardiograms was significantly lower in patients who did not achieve biventricular repair than in those who did (0.012 \u00b1 0.008 cm per week vs 0.028 \u00b1 0.014 cm per week).<\/jats:p>\n               <jats:p>CONCLUSIONS. Fetal tricuspid valve z score and rate of growth predict postnatal outcome in pulmonary atresia with intact ventricular septum. These findings may have important implications for prenatal counseling and selection of patients for fetal pulmonary valve dilation.<\/jats:p>","DOI":"10.1542\/peds.2006-0428","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T17:07:56Z","timestamp":1154538476000},"page":"e415-e420","source":"Crossref","is-referenced-by-count":117,"title":["Fetal Tricuspid Valve Size and Growth as Predictors of Outcome in Pulmonary Atresia With Intact Ventricular Septum"],"prefix":"10.1542","volume":"118","author":[{"given":"Joshua W.","family":"Salvin","sequence":"first","affiliation":[{"name":"Departments of Cardiology"},{"name":"Cardiac Surgery, Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doff B.","family":"McElhinney","sequence":"additional","affiliation":[{"name":"Departments of Cardiology"},{"name":"Cardiac Surgery, Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Colan","sequence":"additional","affiliation":[{"name":"Departments of Cardiology"},{"name":"Cardiac Surgery, Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlee","family":"Gauvreau","sequence":"additional","affiliation":[{"name":"Departments of Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.","family":"del Nido","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Surgery, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy J.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Departments of Cardiology"},{"name":"Cardiac Surgery, Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Lock","sequence":"additional","affiliation":[{"name":"Departments of Cardiology"},{"name":"Cardiac Surgery, Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Tworetzky","sequence":"additional","affiliation":[{"name":"Departments of Cardiology"},{"name":"Cardiac Surgery, Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"key":"2021120822423627600_R1","doi-asserted-by":"crossref","unstructured":"Ashburn DA, Blackstone EH, Wells WJ, et al. Determinants of mortality and type of repair in neonates with pulmonary atresia and intact ventricular septum. J Thorac Cardiovasc Surg\u20082004;127:1000\u20131008","DOI":"10.1016\/j.jtcvs.2003.11.057"},{"key":"2021120822423627600_R2","doi-asserted-by":"crossref","unstructured":"Dyamenahalli U, McCrindle BW, McDonald C, et al. Pulmonary atresia with intact ventricular septum: management of, and outcomes for, a cohort of 210 consecutive patients. Cardiol Young.\u20082004;14;299\u2013308","DOI":"10.1017\/S1047951104003087"},{"key":"2021120822423627600_R3","doi-asserted-by":"crossref","unstructured":"Hanley FL, Sade RM, Blackstone EH, Kirklin JW, Freedom RM, Nanda NC. Outcomes in neonatal pulmonary atresia with intact ventricular septum. A multiinstitutional study. J Thorac Cardiovasc Surg\u20081993;105:406\u2013427","DOI":"10.1016\/S0022-5223(19)34223-0"},{"key":"2021120822423627600_R4","doi-asserted-by":"crossref","unstructured":"Rychik J, Levy H, Gaynor JW, DeCampli WM, Spray TL. Outcome after operations for pulmonary atresia with intact ventricular septum. J Thorac Cardiovasc Surg.\u20081998;116:924\u2013931","DOI":"10.1016\/S0022-5223(98)70042-X"},{"key":"2021120822423627600_R5","doi-asserted-by":"crossref","unstructured":"Jahangiri M, Zurakowski D, Bichell D, Mayer JE, del Nido PJ, Jonas RA. Improved results with selective management in pulmonary atresia with intact ventricular septum. J Thorac Cardiovasc Surg.\u20081999;118:1046\u20131055","DOI":"10.1016\/S0022-5223(99)70100-5"},{"key":"2021120822423627600_R6","doi-asserted-by":"crossref","unstructured":"Daubeney PE, Wang D, Delany DJ, et al. Pulmonary atresia with intact ventricular septum: predictors of early and medium-term outcome in a population-based study. J Thorac Cardiovasc Surg.\u20082005;130:1071","DOI":"10.1016\/j.jtcvs.2005.05.044"},{"key":"2021120822423627600_R7","doi-asserted-by":"crossref","unstructured":"Arzt W, Tulzer G, Aigner M, Mair R, Hafner E. Invasive intrauterine treatment of pulmonary atresia\/intact ventricular septum with heart failure. Ultrasound Obstet Gynecol.\u20082003;21;186\u2013188","DOI":"10.1002\/uog.48"},{"key":"2021120822423627600_R8","doi-asserted-by":"crossref","unstructured":"Tulzer G, Arzt W, Franklin RC, Loughna PV, Mair R, Gardiner HM. Fetal pulmonary valvuloplasty for critical pulmonary stenosis or atresia with intact septum. Lancet.\u20082002;360;1567\u20131568","DOI":"10.1016\/S0140-6736(02)11531-5"},{"key":"2021120822423627600_R9","doi-asserted-by":"crossref","unstructured":"Schneider C, McCrindle BW, Carvalho JS, Hornberger LK, McCarthy KP, Daubeney PE. Development of Z-scores for fetal cardiac dimensions from echocardiography. Ultrasound Obstet Gynecol.\u20082005;26;599\u2013605","DOI":"10.1002\/uog.2597"},{"key":"2021120822423627600_R10","doi-asserted-by":"crossref","unstructured":"Giglia TM, Mandell VS, Connor AR, Mayer JE, Jr, Lock JE. Diagnosis and management of right ventricle-dependent coronary circulation in pulmonary atresia with intact ventricular septum. Circulation.\u20081992;86:1516\u20131528","DOI":"10.1161\/01.CIR.86.5.1516"},{"key":"2021120822423627600_R11","doi-asserted-by":"crossref","unstructured":"Giglia TM, Jenkins KJ, Matitiau A, et al. Influence of right heart size on outcome in pulmonary atresia with intact ventricular septum. Circulation.\u20081993;88:2248\u20132256","DOI":"10.1161\/01.CIR.88.5.2248"},{"key":"2021120822423627600_R12","doi-asserted-by":"crossref","unstructured":"Bull C. Current and potential impact of fetal diagnosis on prevalence and spectrum of serious congenital heart disease at term in the UK. British Paediatric Cardiac Association. Lancet\u20081999;35:1242\u20131247","DOI":"10.1016\/S0140-6736(99)01167-8"},{"key":"2021120822423627600_R13","doi-asserted-by":"crossref","unstructured":"Garcia JA, Zellers TM, Weinstein EM, Mahony L. Usefulness of Doppler echocardiography in diagnosing right ventricular coronary arterial communications in patients with pulmonary atresia and intact ventricular septum and comparison with angiography. Am J Cardiol.\u20081998;81:103\u2013104","DOI":"10.1016\/S0002-9149(97)00855-2"},{"key":"2021120822423627600_R14","doi-asserted-by":"crossref","unstructured":"Satou GM, Perry SB, Gauvreau K, Geva T. Echocardiographic predictors of coronary artery pathology in pulmonary atresia with intact ventricular septum. Am J Cardiol.\u20082000;85;1319\u20131324","DOI":"10.1016\/S0002-9149(00)00763-3"},{"key":"2021120822423627600_R15","doi-asserted-by":"crossref","unstructured":"Maeno YV, Boutin C, Hornberger LK, et al. Prenatal diagnosis of right ventricular outflow tract obstruction with intact ventricular septum, and detection of ventriculocoronary connections. Heart.\u20081999;81:661\u2013668","DOI":"10.1136\/hrt.81.6.661"},{"key":"2021120822423627600_R16","doi-asserted-by":"crossref","unstructured":"Fyfe DA, Edwards WD, Driscoll DJ. Myocardial ischemia in patients with pulmonary atresia and intact ventricular septum. J Am Coll Cardiol.\u20081986;8:402\u2013406","DOI":"10.1016\/S0735-1097(86)80058-4"},{"key":"2021120822423627600_R17","doi-asserted-by":"crossref","unstructured":"Powell AJ, Mayer JE, Lang P, Lock JE. Outcome in infants with pulmonary atresia, intact ventricular septum, and right ventricle-dependent coronary circulation. Am J Cardiol\u20082000;86:1272\u20131274, A9","DOI":"10.1016\/S0002-9149(00)01220-0"},{"key":"2021120822423627600_R18","doi-asserted-by":"crossref","unstructured":"Odim J, Laks H, Plunkett MD, Tung TC. Successful management of patients with pulmonary atresia with intact ventricular septum using a three tier grading system for right ventricular hypoplasia. Ann Thorac Surg.\u20082006;81;678\u2013684","DOI":"10.1016\/j.athoracsur.2005.07.060"},{"key":"2021120822423627600_R19","doi-asserted-by":"crossref","unstructured":"Yoshimura N, Yamaguchi M, Ohashi H, et al. Pulmonary atresia with intact ventricular septum: strategy based on right ventricular morphology. J Thorac Cardiovasc Surg.\u20082003;126;1417\u20131426","DOI":"10.1016\/S0022-5223(03)01035-3"},{"key":"2021120822423627600_R20","doi-asserted-by":"crossref","unstructured":"Kohl T, Sharland G, Allan LD, et al. World experience of percutaneous ultrasound-guided balloon valvuloplasty in human fetuses with severe aortic valve obstruction. Am J Cardiol.\u20082000;85;1230\u20131233","DOI":"10.1016\/S0002-9149(00)00733-5"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/118\/2\/e415\/1074601\/zpe0080600e415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/118\/2\/e415\/1074601\/zpe0080600e415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T02:31:53Z","timestamp":1639017113000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/118\/2\/e415\/69047\/Fetal-Tricuspid-Valve-Size-and-Growth-as"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,8,1]]},"published-print":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2006-0428","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,1]]}}}