{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:15:32Z","timestamp":1791357332406,"version":"4.3.1"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:p>From 2003 to 2005, deaths of 3 individuals as a result of cardiac arrest caused by hypocalcemia during chelation therapy were reported to the Centers for Disease Control and Prevention. Two were children, both of whom were treated with edetate disodium. At the time of this writing, the adult case was still under investigation. No previous cases of death resulting from hypocalcemia during chelation have been reported. From our experience and review of the literature, we suggest that health care providers who are unfamiliar with chelation consult an expert before undertaking treatment and that hospital formularies evaluate whether stocking edetate disodium is necessary, given the risk for hypocalcemia and the availability of less toxic alternatives.<\/jats:p>","DOI":"10.1542\/peds.2006-0858","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T17:07:56Z","timestamp":1154538476000},"page":"e534-e536","source":"Crossref","is-referenced-by-count":83,"title":["Deaths Resulting From Hypocalcemia After Administration of Edetate Disodium: 2003-2005"],"prefix":"10.1542","volume":"118","author":[{"given":"Mary Jean","family":"Brown","sequence":"first","affiliation":[{"name":"Lead Poisoning Prevention Branch, Division of Emergency and Environmental Health Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Willis","sequence":"additional","affiliation":[{"name":"Blood Lead Surveillance Group, Texas Department of State Health Services, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennet","family":"Omalu","sequence":"additional","affiliation":[{"name":"Allegheny County Medical Examiner's Office, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Leiker","sequence":"additional","affiliation":[{"name":"Lead Poisoning Prevention Program, Oregon State Public Health, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"key":"2021120822371715400_R1","doi-asserted-by":"crossref","unstructured":"Chisholm JJ Jr, Harrison HE. 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Atlanta, GA: US Department Health and Human Services, Agency for Toxic Substances and Disease Registry; 1999"},{"key":"2021120822371715400_R13","unstructured":"Endrate [package insert]. Lake Forest, IL: Hospira Inc; 2005"},{"key":"2021120822371715400_R14","unstructured":"Centers for Disease Control and Prevention. Preventing Lead Poisoning in Young Children: A Statement by the Centers for Disease Control. Atlanta, GA: Centers for Disease Control and Prevention; 1978. Available at: www.cdc.gov\/nceh\/lead\/Publications\/books\/plpyc\/plpyc_history\/CLP_197. Accessed April 6, 2006"},{"key":"2021120822371715400_R15","unstructured":"Institute of Medicine. Immunization Safety Review: Vaccines and Autism. Washington, DC: National Academies Press; 2004"},{"key":"2021120822371715400_R16","unstructured":"National Center for Complementary and Alternative Medicine, National Institutes of Health. 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