{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:51:17Z","timestamp":1789527077562,"version":"build-2803163510"},"reference-count":39,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:p>OBJECTIVES. This study examined whether atopic disposition, wheezing, and atopic disorders increased the risk of hospitalizations because of respiratory syncytial virus in children between birth and 18 months of age.<\/jats:p><jats:p>PATIENTS AND METHODS. Relative risks for respiratory syncytial virus hospitalization were studied in a nested 1:5 case-control design using exposure information obtained from interviews with mothers of 2564 case and 12816 control children who had been followed prospectively from birth and until 18 months of age as participants in the Danish National Birth Cohort. Information on the children's ages at respiratory syncytial virus hospitalization, presentation of infrequent wheezing, recurrent wheezing, and atopic dermatitis were used to study these associations chronologically.<\/jats:p><jats:p>RESULTS. The adjusted relative risk of respiratory syncytial virus hospitalization in the offspring was 1.11 for maternal atopic dermatitis, 1.72 for maternal asthma, and 1.23 for paternal asthma. Atopic dermatitis in the child was associated with an increased risk of subsequent respiratory syncytial virus hospitalization among infants &amp;lt;6 months of age. Infrequent wheezing was associated with a relative risk of subsequent respiratory syncytial virus hospitalization of 2.98 and recurrent wheezing with a relative risk of 5.90. These associations were present also if infants with medical risk factors were excluded from the analysis.<\/jats:p><jats:p>CONCLUSIONS. Asthmatic disposition and wheezing were strong determinants of subsequent respiratory syncytial virus hospitalization in Danish children &amp;lt;18 months of age.<\/jats:p>","DOI":"10.1542\/peds.2006-0907","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T18:04:44Z","timestamp":1162490684000},"page":"e1360-e1368","source":"Crossref","is-referenced-by-count":79,"title":["Atopic Disposition, Wheezing, and Subsequent Respiratory Syncytial Virus Hospitalization in Danish Children Younger Than 18 Months: A Nested Case-Control Study"],"prefix":"10.1542","volume":"118","author":[{"given":"Lone Graff","family":"Stensballe","sequence":"first","affiliation":[{"name":"Danish Epidemiology Science Centre, Statens Serum Institut, Denmark"},{"name":"Bandim Health Project, Bissau, Guinea-Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Paediatric Clinic 2, Rigshospitalet, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.F.","family":"Simoes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, and The Children's Hospital, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Epidemiology Science Centre, Statens Serum Institut, Denmark"},{"name":"Bandim Health Project, Bissau, Guinea-Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Danish Epidemiology Science Centre, Statens Serum Institut, Denmark"},{"name":"Bandim Health Project, Bissau, Guinea-Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Stabell","family":"Benn","sequence":"additional","affiliation":[{"name":"Danish Epidemiology Science Centre, Statens Serum Institut, Denmark"},{"name":"Bandim Health Project, Bissau, Guinea-Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Aaby","sequence":"additional","affiliation":[{"name":"Danish Epidemiology Science Centre, Statens Serum Institut, Denmark"},{"name":"Bandim Health Project, Bissau, Guinea-Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Danish RSV Data Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"2021120823175126600_R1","doi-asserted-by":"crossref","unstructured":"Simoes EA. 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Pediatr Allergy Immunol.\u20082005;16:386\u2013392","DOI":"10.1111\/j.1399-3038.2005.00298.x"},{"key":"2021120823175126600_R5","doi-asserted-by":"crossref","unstructured":"Bont L, Steijn M, van Aalderen WM, et al. Seasonality of long term wheezing following respiratory syncytial virus lower respiratory tract infection. Thorax.\u20082004;59:512\u2013516","DOI":"10.1136\/thx.2003.013391"},{"key":"2021120823175126600_R6","doi-asserted-by":"crossref","unstructured":"Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet.\u20081999;354:541\u2013545","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"2021120823175126600_R7","doi-asserted-by":"crossref","unstructured":"Sigurs N, Gustafsson PM, Bjarnason R, et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. 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Am J Epidemiol.\u20081991;133:1135\u20131151","DOI":"10.1093\/oxfordjournals.aje.a115826"},{"key":"2021120823175126600_R29","doi-asserted-by":"crossref","unstructured":"Downham MA, Scott R, Sims DG, Webb JK, Gardner PS. Breast-feeding protects against respiratory syncytial virus infections. Br Med J.\u20081976;2:274\u2013276","DOI":"10.1136\/bmj.2.6030.274"},{"key":"2021120823175126600_R30","doi-asserted-by":"crossref","unstructured":"Stensballe LG, Poulsen A, Nante E, et al. Mothers may transmit RSV infection more easily to sons than daughters. Community study from Guinea-Bissau. Scand J Infect Dis.\u20082004;36:291\u2013295","DOI":"10.1080\/00365540410019589"},{"key":"2021120823175126600_R31","unstructured":"Tepper RS, Morgan WJ, Cota K, Wright A, Taussig LM. Physiologic growth and development of the lung during the first year of life. Am Rev Respir Dis.\u20081986;134:513\u2013519"},{"key":"2021120823175126600_R32","doi-asserted-by":"crossref","unstructured":"Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med.\u20081995;332:133\u2013138","DOI":"10.1056\/NEJM199501193320301"},{"key":"2021120823175126600_R33","doi-asserted-by":"crossref","unstructured":"Landau LI, Morgan W, McCoy KS, Taussig LM. Gender related differences in airway tone in children. Pediatr Pulmonol.\u20081993;16:31\u201335","DOI":"10.1002\/ppul.1950160107"},{"key":"2021120823175126600_R34","doi-asserted-by":"crossref","unstructured":"Verity CM, Vanheule B, Carswell F, Hughes AO. Bronchial lability and skin reactivity in siblings of asthmatic children. 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