{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:40:33Z","timestamp":1792636833795,"version":"4.5.0"},"reference-count":34,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:p>OBJECTIVE. Fatty liver disease is diagnosed increasingly in children, but the prevalence remains unknown. We sought to determine the prevalence of pediatric fatty liver as diagnosed by histology in a population-based sample.<\/jats:p>\n               <jats:p>METHODS. We conducted a retrospective review of 742 children between the ages of 2 and 19 years who had an autopsy performed by a county medical examiner from 1993 to 2003. Fatty liver was defined as \u22655% of hepatocytes containing macrovesicular fat.<\/jats:p>\n               <jats:p>RESULTS. Fatty liver was present in 13% of subjects. For children and adolescents age 2 to 19 years, the prevalence of fatty liver adjusted for age, gender, race, and ethnicity is estimated to be 9.6%. Fatty liver prevalence increases with age, ranging from 0.7% for ages 2 to 4 up to 17.3% for ages 15 to 19 years. Fatty liver prevalence differs significantly by race and ethnicity (Asian: 10.2%; black: 1.5%; Hispanic: 11.8%; white: 8.6%). The highest rate of fatty liver was seen in obese children (38%).<\/jats:p>\n               <jats:p>CONCLUSIONS. Fatty liver is the most common liver abnormality in children age 2 to 19 years. The presence of macrovesicular hepatic steatosis in \u223c1 of every 10 children has important ramifications for the long-term health of children and young adults. The influence of the risk factors identified should be taken into consideration in the development of protocols designed to screen at-risk children and adolescents.<\/jats:p>","DOI":"10.1542\/peds.2006-1212","type":"journal-article","created":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T17:04:22Z","timestamp":1159808662000},"page":"1388-1393","source":"Crossref","is-referenced-by-count":1215,"title":["Prevalence of Fatty Liver in Children and Adolescents"],"prefix":"10.1542","volume":"118","author":[{"given":"Jeffrey B.","family":"Schwimmer","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaz","family":"Kahen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel E.","family":"Lavine","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California, San Diego School of Medicine, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Behling","sequence":"additional","affiliation":[{"name":"Office of the Medical Examiner, County of San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2006,10,1]]},"reference":[{"key":"2021120822451702200_R1","doi-asserted-by":"crossref","unstructured":"Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM. 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