{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:47:26Z","timestamp":1791301646854,"version":"4.1.0"},"reference-count":36,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"abstract":"<jats:p>OBJECTIVE. Our goal was to relate postnatal dexamethasone therapy in extremely low birth weight infants (birth weight of \u22641000 g) to their total and regional brain volumes, as measured by volumetric MRI performed at term-equivalent age.<\/jats:p><jats:p>METHODS. Among 53 extremely low birth weight infants discharged between June 1 and December 31, 2003, 41 had high-quality MRI studies; 30 of those infants had not received postnatal steroid treatment and 11 had received dexamethasone, all after postnatal age of 28 days, for a mean duration of 6.8 days and a mean cumulative dose of 2.8 mg\/kg. Anatomic brain MRI scans obtained at 39.5 weeks (mean) postmenstrual age were segmented by using semiautomated and manual, pretested, scoring algorithms to generate three-dimensional cerebral component volumes. Volumes were adjusted according to postmenstrual age at MRI.<\/jats:p><jats:p>RESULTS. After controlling for postmenstrual age at MRI, we observed a 10.2% smaller total cerebral tissue volume in the dexamethasone-treated group, compared with the untreated group. Cortical tissue volume was 8.7% smaller in the treated infants, compared with untreated infants. Regional volume analysis revealed a 20.6% smaller cerebellum and a 19.9% reduction in subcortical gray matter in the dexamethasone-treated infants, compared with untreated infants. In a series of regression analyses, the reductions in total cerebral tissue, subcortical gray matter, and cerebellar volumes associated with dexamethasone administration remained significant after controlling not only for postmenstrual age but also for bronchopulmonary dysplasia and birth weight.<\/jats:p><jats:p>CONCLUSIONS. We identified smaller total and regional cerebral tissue volumes in extremely low birth weight infants treated with relatively conservative regimens of dexamethasone. These volume deficits may be the structural antecedents of neuromotor and cognitive abnormalities reported after postnatal dexamethasone treatment.<\/jats:p>","DOI":"10.1542\/peds.2006-1354","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T06:46:57Z","timestamp":1170485217000},"page":"265-272","source":"Crossref","is-referenced-by-count":110,"title":["Postnatal Dexamethasone Therapy and Cerebral Tissue Volumes in Extremely Low Birth Weight Infants"],"prefix":"10.1542","volume":"119","author":[{"given":"Nehal A.","family":"Parikh","sequence":"first","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Lasky","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics"},{"name":"Center for Clinical Research and Evidence-Based Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics"},{"name":"Center for Clinical Research and Evidence-Based Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando R.","family":"Moya","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Hochhauser","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Texas Medical School at Houston, Houston, Texas"},{"name":"Department of Neuroradiology, Memorial Hermann Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seferino","family":"Romo","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Memorial Hermann Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon E.","family":"Tyson","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics"},{"name":"Center for Clinical Research and Evidence-Based Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2007,2,1]]},"reference":[{"key":"2021120823344004400_R1","doi-asserted-by":"crossref","unstructured":"Marlow N, Wolke D, Bracewell MA, Samara M. 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Pediatrics.\u20082003;111:939\u2013948","DOI":"10.1542\/peds.111.5.939"},{"key":"2021120823344004400_R11","unstructured":"Anderson PJ, Howard K, Bear M, et al. Relationship between regional brain volumes at term equivalent and cognitive functioning at 2 years in preterm children. Pediatr Res.\u20082004;55:3294A"},{"key":"2021120823344004400_R12","doi-asserted-by":"crossref","unstructured":"Murphy BP, Inder TE, Huppi PS, et al. Impaired cerebral cortical gray matter growth after treatment with dexamethasone for neonatal chronic lung disease. Pediatrics.\u20082001;107:217\u2013221","DOI":"10.1542\/peds.107.2.217"},{"key":"2021120823344004400_R13","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, Committee on Fetus and Newborn. Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics.\u20082002;109:330\u2013338","DOI":"10.1542\/peds.109.2.330"},{"key":"2021120823344004400_R14","doi-asserted-by":"crossref","unstructured":"Valkama AM, Paakko EL, Vainionpaa LK, Lanning FP, Ilkko EA, Koivisto ME. Magnetic resonance imaging at term and neuromotor outcome in preterm infants. Acta Paediatr.\u20082000;89:348\u2013355","DOI":"10.1111\/j.1651-2227.2000.tb01337.x"},{"key":"2021120823344004400_R15","doi-asserted-by":"crossref","unstructured":"Rademaker KJ, Uiterwaal CS, Beek FJ, et al. Neonatal cranial ultrasound versus MRI and neurodevelopmental outcome at school age in children born preterm. Arch Dis Child Fetal Neonatal Ed.\u20082005;90:F489\u2013F493","DOI":"10.1136\/adc.2005.073908"},{"key":"2021120823344004400_R16","doi-asserted-by":"crossref","unstructured":"Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr.\u20081991;119:417\u2013423","DOI":"10.1016\/S0022-3476(05)82056-6"},{"key":"2021120823344004400_R17","doi-asserted-by":"crossref","unstructured":"Walsh MC, Yao Q, Gettner P, Hale E, et al. National Institute of Child Health and Human Development Neonatal Research Network: impact of a physiologic definition on bronchopulmonary dysplasia rates. Pediatrics.\u20082004;114:1305\u20131311","DOI":"10.1542\/peds.2004-0204"},{"key":"2021120823344004400_R18","doi-asserted-by":"crossref","unstructured":"Pinto-Martin JA, Riolo S, Cnaan A, Holzman C, Susser MW, Paneth N. Cranial ultrasound prediction of disabling and nondisabling cerebral palsy at age two in a low birth weight population. Pediatrics.\u20081995;95:249\u2013254","DOI":"10.1542\/peds.95.2.249"},{"key":"2021120823344004400_R19","doi-asserted-by":"crossref","unstructured":"Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr.\u20081978;92:529\u2013534","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"2021120823344004400_R20","doi-asserted-by":"crossref","unstructured":"Lasky RE, Luck ML, Parikh NA, Laughlin NK. The effects of early lead exposure on the brains of adult rhesus monkeys: a volumetric MRI study. Toxicol Sci.\u20082005;85:963\u2013975","DOI":"10.1093\/toxsci\/kfi153"},{"key":"2021120823344004400_R21","unstructured":"Haines DE. Neuroanatomy: An Atlas of Structures, Sections and Systems. 3rd ed. Baltimore, MD: Williams & Wilkins; 1991"},{"key":"2021120823344004400_R22","unstructured":"University of Michigan. The navigable atlas of the human brain. Available at: www.msu.edu\/\u223cbrains\/humanatlas. Accessed January 6, 2005"},{"key":"2021120823344004400_R23","unstructured":"University of Washington, Structural Informatics Group. 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