{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:53:54Z","timestamp":1762001634549,"version":"3.40.5"},"reference-count":37,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>OBJECTIVE. The objective of this study was to determine the incidence of multidrug-resistant bacteria in hospitalized children<\/jats:p>\n               <jats:p>METHODS. This multicenter study was conducted in 5 hospitals in the Paris area from 1999 to 2003. We recorded all isolations of multidrug-resistant bacteria from clinical samples that were obtained from hospitalized children. Strains that were isolated during systematic screening for carriers were excluded.<\/jats:p>\n               <jats:p>RESULTS. The mean incidences were 0.9 per 1000 hospitalization-days for methicillin-resistant Staphylococcus aureus, 0.45 for extended-spectrum \u03b2-lactamase\u2013producing Klebsiella pneumoniae, 0.32 for extended-spectrum \u03b2-lactamase\u2013producing Enterobacteriaceae other than Klebsiella pneumoniae, 0.40 for Enterobacter species with derepressed cephalosporinase, and 0.01 for vancomycin-resistant Enterococcus. The incidences per 1000 hospitalization-days of methicillin-resistant Staphylococcus aureus, extended-spectrum \u03b2-lactamase\u2013producing Klebsiella pneumoniae, extended-spectrum \u03b2-lactamase\u2013producing Enterobacteriaceae other than Klebsiella pneumoniae, and Enterobacter species with derepressed cephalosporinase decreased significantly from 1999 to 2003, whereas the incidence of vancomycin-resistant Enterococcus remained very low. The proportion of resistant strains within the species did not vary significantly for methicillin-resistant Staphylococcus aureus (11% to 9.6%), extended-spectrum \u03b2-lactamase\u2013producing Enterobacteriaceae other than Klebsiella pneumoniae (1.1%), and vancomycin-resistant Enterococcus (0.03% to 0.023%). In contrast, the frequency of extended-spectrum \u03b2-lactamase\u2013producing Klebsiella pneumoniae decreased from 31.6% to 7.4%, and that of Enterobacter species with derepressed cephalosporinase decreased from 38.8% to 18.5%.<\/jats:p>\n               <jats:p>CONCLUSIONS. We report significant decreases in the incidence of methicillin-resistant Staphylococcus aureus, extended-spectrum \u03b2-lactamase\u2013producing Klebsiella pneumoniae, extended-spectrum \u03b2-lactamase\u2013producing Enterobacteriaceae other than Klebsiella pneumoniae, and Enterobacter species with derepressed cephalosporinase in hospitalized children during a 5-year period.<\/jats:p>","DOI":"10.1542\/peds.2006-1384","type":"journal-article","created":{"date-parts":[[2007,4,2]],"date-time":"2007-04-02T16:23:29Z","timestamp":1175531009000},"page":"e798-e803","source":"Crossref","is-referenced-by-count":20,"title":["Multidrug-Resistant Bacteria in Hospitalized Children: A 5-Year Multicenter Study"],"prefix":"10.1542","volume":"119","author":[{"given":"Josette","family":"Raymond","sequence":"first","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Cochin-Saint Vincent de Paul, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital de Bice\u0302tre, Kremlin-Bice\u0302tre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Doit","sequence":"additional","affiliation":[{"name":"Service de Microbiologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang","family":"Vu Thien","sequence":"additional","affiliation":[{"name":"Service de Ne\u0301onatologie, Ho\u0302pital Robert Debre\u0301, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miche\u0300le","family":"Guibert","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Trousseau, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agne\u0300s","family":"Ferroni","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Aujard","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Necker Enfants-Malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"2021120823304228100_R1","doi-asserted-by":"crossref","unstructured":"Ho PL, for the Hong Kong Intensive Care Unit Antimicrobial Resistance Study (HK-ICARE) Group. 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