{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:21:18Z","timestamp":1773292878488,"version":"3.50.1"},"reference-count":20,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:p>Mild hyperbilirubinemia is a clinical feature of hemolysis. Here we describe a boy with marked elevation of serum bilirubin values (maximum: 70 mg\/dL) during an acute episode of autoimmune hemolytic anemia, which returned to within the reference range after clinical improvement. The boy was a homozygous carrier of short alleles of the heme oxygenase-1 (HO-1) gene GT dinucleotide-repeat promoter polymorphism, which is associated with increased activity and inducibility of the heme-degrading enzyme HO-1, which catalyzes the production of bilirubin. In addition, heterozygosity of the uridine 5\u2032-diphosphate-glucuronosyl-transferase 1A1 promoter polymorphism that is linked with Gilbert syndrome was found in this patient. Because bilirubin production plays a critical role during the neonatal period, the HO-1 promoter polymorphism may be an important genetic factor for the clinical outcome of neonatal hyperbilirubinemia.<\/jats:p>","DOI":"10.1542\/peds.2006-1385","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T01:34:46Z","timestamp":1172540086000},"page":"e764-e767","source":"Crossref","is-referenced-by-count":14,"title":["Marked Hyperbilirubinemia Associated With the Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism in a Boy With Autoimmune Hemolytic Anemia"],"prefix":"10.1542","volume":"119","author":[{"given":"Stephan","family":"Immenschuh","sequence":"first","affiliation":[{"name":"Institute of Clinical Immunology and Transfusion Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Kroll","sequence":"additional","affiliation":[{"name":"Institute of Clinical Immunology and Transfusion Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sentot","family":"Santoso","sequence":"additional","affiliation":[{"name":"Institute of Clinical Immunology and Transfusion Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Wo\u0308ssmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Bein","sequence":"additional","affiliation":[{"name":"Institute of Clinical Immunology and Transfusion Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert L.","family":"Bonkovsky","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2007,3,1]]},"reference":[{"key":"2021120901512667000_R1","doi-asserted-by":"crossref","unstructured":"Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science.\u20081987;235:1043\u20131046","DOI":"10.1126\/science.3029864"},{"key":"2021120901512667000_R2","doi-asserted-by":"crossref","unstructured":"Mayer M. Association of serum bilirubin concentration with risk of coronary artery disease. Clin Chem.\u20082000;46:1723\u20131727","DOI":"10.1093\/clinchem\/46.11.1723"},{"key":"2021120901512667000_R3","doi-asserted-by":"crossref","unstructured":"Sedlak TW, Snyder SH. Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics.\u20082004;113:1776\u20131782","DOI":"10.1542\/peds.113.6.1776"},{"key":"2021120901512667000_R4","doi-asserted-by":"crossref","unstructured":"Kapitulnik J. Bilirubin: an endogenous product of heme degradation with both cytotoxic and cytoprotective properties. 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Gene regulation of heme oxygenase-1 as a therapeutic target. Biochem Pharmacol.\u20082000;60:1121\u20131128","DOI":"10.1016\/S0006-2952(00)00443-3"},{"key":"2021120901512667000_R13","doi-asserted-by":"crossref","unstructured":"Ryter SW, Alam J, Choi AM. Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications. Physiol Rev.\u20082006;86:583\u2013650","DOI":"10.1152\/physrev.00011.2005"},{"key":"2021120901512667000_R14","doi-asserted-by":"crossref","unstructured":"Belcher JD, Mahaseth H, Welch TE, Otterbein LE, Hebbel RP, Vercellotti GM. Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest.\u20082006;116:808\u2013816","DOI":"10.1172\/JCI26857"},{"key":"2021120901512667000_R15","doi-asserted-by":"crossref","unstructured":"Yamada N, Yamaya M, Okinaga S, et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet.\u20082000;66:187\u2013195","DOI":"10.1086\/302729"},{"key":"2021120901512667000_R16","doi-asserted-by":"crossref","unstructured":"Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med.\u20082004;37:1097\u20131104","DOI":"10.1016\/j.freeradbiomed.2004.07.008"},{"key":"2021120901512667000_R17","doi-asserted-by":"crossref","unstructured":"Nath KA, Balla G, Vercellotti GM, et al. Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest.\u20081992;90:267\u2013270","DOI":"10.1172\/JCI115847"},{"key":"2021120901512667000_R18","doi-asserted-by":"crossref","unstructured":"Bosma PJ, Chowdhury JR, Bakker C, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. 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Pediatr Res.\u20082003;54:165\u2013171","DOI":"10.1203\/01.PDR.0000072329.56635.35"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/119\/3\/e764\/1112576\/zpe0030700e764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/119\/3\/e764\/1112576\/zpe0030700e764.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T07:55:18Z","timestamp":1639036518000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/119\/3\/e764\/70377\/Marked-Hyperbilirubinemia-Associated-With-the-Heme"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,1]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,3,1]]},"published-print":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2006-1385","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,1]]}}}